New blood and urine tests can detect autism in children - Sensationalist Headlines

[img]https://i.imgur.com/U5LKfO7.jpg[/img] [QUOTE]Scientists in Britain say they have developed a blood and urine test that can detect autism in children. Researchers at the University of Warwick said the test, believed to be the first of its kind, could lead to earlier diagnosis of autism spectrum disorders (ASD) in children who could then be given appropriate treatment much earlier in their lives. ASDs mainly affect a person’s social interaction and communication, with symptoms that can include speech disturbances, repetitive and/or compulsive behaviour, hyperactivity, anxiety, and difficulty adapting to new environments. As there is a wide range of ASD symptoms, diagnosis can be difficult and uncertain, particularly at the early stages of development. It is estimated that about one in every 100 people in the UK has ASD, with more boys diagnosed with the condition than girls. Scientists said their research found a link between ASD and damage to proteins in blood plasma. They found the most reliable of the tests they developed was examining protein in blood plasma, which found children with ASD had higher levels of the oxidation marker dityrosine (DT) and certain sugar-modified compounds called advanced glycation end-products (AGEs). Genetic causes are thought to be responsible for about a third of cases of ASD, while the rest are believed to be caused by a combination of environmental factors, mutations, and rare genetic variants. However, researchers believe their new tests could reveal yet-to-be-identified causes of ASD. They also confirmed the previously held belief that mutations of amino acid transporters are a genetic variant associated with ASD.[/QUOTE] [URL="https://www.theguardian.com/society/2018/feb/19/autism-children-blood-urine-test"]Source[/URL].

imagine pissing in a cup and finding out you're autistic

Better than saying "he doesn't look me in the eye when he talks" or "she daydreams and forgets her belongings more often than most" and prescribing drugs

I bet it just detects if the child was vaccinated

sign me up

[QUOTE=GentlemanLexi;53143337]imagine pissing in a cup and finding out you're autistic[/QUOTE] nothing really out of the ordinary for me :(

Imagine that this test goes public as a valid, reliable and primary diagnosing process for ASD and then it to be used on a large scale study to about autism distribution, unknown cases etc. only to find out that there are like 30% of the tested people having it or something. I think most cases are still a kind of unnoticed in a lifetime, because they would be at the very low end of the spectrum. If these cases were also revealed, people would think of an autism epidemy. Later they would hopefully recognize that it is not that bad in the most cases.

[QUOTE=GentlemanLexi;53143337]imagine pissing in a cup and finding out you're autistic[/QUOTE] i had to shit in a urinal to find out i was autistic :/

[QUOTE=myon;53143359]nothing really out of the ordinary for me :([/QUOTE] There's a time and place to do such things.

Doesn't sound like it would be reliable enough to actually use if they're only measuring markers related to metabolism and oxidative stress. Might lead to something interesting though.

isn't getting plasma taken out supposed to be really painful?

[QUOTE=kr1f333;53143569]isn't getting plasma taken out supposed to be really painful?[/QUOTE] no more painful than taking a blood sample and obtaining plasma from it after centrifuging for the test purpose

[QUOTE=GentlemanLexi;53143337]imagine pissing in a cup and finding out you're autistic[/QUOTE] This is highly contextual however, like if you just grab a cup and take a piss in it, you're not going to know, unless your piss spells out Autism, but that's just another thing altogether I reckon.

[QUOTE=GHOST!!!!;53143591]This is highly contextual however, like if you just grab a cup and take a piss in it, you're not going to know, unless your piss spells out Autism, but that's just another thing altogether I reckon.[/QUOTE] I mean my piss usually just spells "Predisposition For Diabetes" but I don't know if this is replicable in other people

[QUOTE=spazthemax;53143339]Better than saying "[B]he doesn't look me in the eye when he talks[/B]" or "she daydreams and forgets her belongings more often than most" and prescribing drugs[/QUOTE] wait that's a thing? im always looking around when i speak to people

[QUOTE=krakadict;53143678]wait that's a thing? im always looking around when i speak to people[/QUOTE] Social stuff in general is a one of the most common indicators.

[QUOTE=kr1f333;53143569]isn't getting plasma taken out supposed to be really painful?[/QUOTE] You're probably thinking about bone marrow.

[QUOTE=myon;53143359]nothing really out of the ordinary for me :([/QUOTE] Don't be sad. If your mind operated differently, then you wouldn't be the person you are today. You might not have even found Facepunch and that's just no good. That's how I see it anyway. Being on the spectrum doesn't have to be a negative thing.

[QUOTE=kr1f333;53143569]isn't getting plasma taken out supposed to be really painful?[/QUOTE] [QUOTE=phygon;53143712]You're probably thinking about bone marrow.[/QUOTE] Its painful if you're skinny, there's no good major veins visible and the tech doesn't know what he's doing.

[QUOTE=krakadict;53143678]wait that's a thing? im always looking around when i speak to people[/QUOTE] I look people in the eye when I talk, but I can't look them in the eye while they're talking without feeling intrusive and awkward. It's different for literally every individual, though.

[QUOTE=Tobba;53143542]Doesn't sound like it would be reliable enough to actually use if they're only measuring markers related to metabolism and oxidative stress. Might lead to something interesting though.[/QUOTE] 92% sensitivity and 84% specificity seems quite good IMHO. Especially for a non-invasive piss test. [QUOTE=https://molecularautism.biomedcentral.com/track/pdf/10.1186/s13229-017-0183-3?site=molecularautism.biomedcentral.com]We found that children with ASD had increased advanced glycation endproducts (AGEs), Nε-carboxymethyllysine (CML) and Nω-carboxymethylarginine (CMA), and increased oxidation damage marker, dityrosine (DT), in plasma protein, with respect to healthy controls. We also found that children with ASD had increased CMA free adduct in plasma ultrafiltrate and increased urinary excretion of oxidation free adducts, alpha-aminoadipic semialdehyde and glutamic semialdehyde. From study of renal handling of amino acids, we found that children with ASD had decreased renal clearance of arginine and CMA with respect to healthy controls. Algorithms to discriminate between ASD and healthy controls gave strong diagnostic performance with features: plasma protein AGEs—CML, CMA—and 3-deoxyglucosonederived hydroimidazolone, and oxidative damage marker, DT. The sensitivity, specificity, and receiver operating characteristic area-under-the-curve were 92%, 84%, and 0.94, respectively.[/QUOTE]

[QUOTE=LoneWolf_Recon;53143771]Its painful if you're skinny, there's no good major veins visible and the tech doesn't know what he's doing.[/QUOTE] I'm skinny (125lbs/6ft) and I've only had maybe 2 nurses be total fuckups when trying to draw blood I have some chronic disease problems so I've had my blood taken 50+ times since I was 7

[QUOTE=spazthemax;53144106]I'm skinny (125lbs/6ft) and I've only had maybe 2 nurses be total fuckups when trying to draw blood I have some chronic disease problems so I've had my blood taken 50+ times since I was 7[/QUOTE] It may have been just me (my prev. post was speaking from experience). I'm similar to you build-wise and it sucked everytime when they jab it in the arm. Admittedly I'm also hemophobic so there's that.

[QUOTE=GentlemanLexi;53143337]imagine pissing in a cup and finding out you're autistic[/QUOTE] Honestly, using this forum should be enough of an indicator for autism.

[QUOTE=LoneWolf_Recon;53144133]It may have been just me (my prev. post was speaking from experience). I'm similar to you build-wise and it sucked everytime when they jab it in the arm. Admittedly I'm also hemophobic so there's that.[/QUOTE] Might be possible for that vein to just not run very close to the skin for you. Even still I'd be surprised if the tourniquets didn't make those few veins present themselves, though. But the further they have to stick the needle, the worse it gets for sure.

[QUOTE=jimbobjoe1234;53144181]Honestly, using this forum should be enough of an indicator for autism.[/QUOTE] Well posting here is just like pissing in a [del]sea[/del] cup of piss.

[img]https://i.imgur.com/ZGnnKsU.png[/img] :v:

Wow Drug Tests are becoming more accurate each day.

[QUOTE=GHOST!!!!;53143591]This is highly contextual however, like if you just grab a cup and take a piss in it, you're not going to know, unless your piss spells out Autism, but that's just another thing altogether I reckon.[/QUOTE] If you piss in cups, there might be something wrong with you.

[QUOTE=GentlemanLexi;53143337]imagine pissing in a cup and finding out you're autistic[/QUOTE] Maybe the act itself is part of the test? "Please pee in this cup." "Okay HEY WANNA SEE HOW HARD I CAN PEE?! HNNNNNNNNG-" *checks box on form* [QUOTE=GHOST!!!!;53143591]This is highly contextual however, like if you just grab a cup and take a piss in it, you're not going to know, unless your piss [B]spells out Autism[/B], but that's just another thing altogether I reckon.[/QUOTE] [QUOTE=ThatSwordGuy;53143646]I mean my piss usually just [B]spells "Predisposition For Diabetes"[/B] but I don't know if this is replicable in other people[/QUOTE] No idea what mine spells out because it didn't really snow this winter. :/