• Stuffing Your Face Stuffs Your 'Food Clock'.
    19 replies, posted
[quote] [h2]How Excess Holiday Eating Disturbs Your 'Food Clock'[/h2] [quote] [IMG]http://images.sciencedaily.com/2012/12/121224113351.jpg[/IMG] ============================================================ A new study examines the role of a key molecule in the body's metabolism, which eating at odd times can upset. (Credit: © fabiomax / Fotolia) [/quote] If the sinful excess of holiday eating sends your system into butter-slathered, brandy-soaked overload, you are not alone: People who are jet-lagged, people who work graveyard shifts and plain-old late-night snackers know just how you feel. All these activities upset the body's "food clock," a collection of interacting genes and molecules known technically as the food-entrainable oscillator, which keeps the human body on a metabolic even keel. A new study by researchers at the University of California, San Francisco (UCSF) is helping to reveal how this clock works on a molecular level. Published this month in the journal Proceedings of the National Academy of Sciences, the UCSF team has shown that a protein called PKCγ is critical in resetting the food clock if our eating habits change. The study showed that normal laboratory mice given food only during their regular sleeping hours will adjust their food clock over time and begin to wake up from their slumber, and run around in anticipation of their new mealtime. But mice lacking the PKCγ gene are not able to respond to changes in their meal time -- instead sleeping right through it. The work has implications for understanding the molecular basis of diabetes, obesity and other metabolic syndromes because a desynchronized food clock may serve as part of the pathology underlying these disorders, said Louis Ptacek, MD, the John C. Coleman Distinguished Professor of Neurology at UCSF and a Howard Hughes Medical Institute Investigator. It may also help explain why night owls are more likely to be obese than morning larks, Ptacek said. "Understanding the molecular mechanism of how eating at the "wrong" time of the day desynchronizes the clocks in our body can facilitate the development of better treatments for disorders associated with night-eating syndrome, shift work and jet lag," he added. [B]Resetting the Food Clock[/B] Look behind the face of a mechanical clock and you will see a dizzying array of cogs, flywheels, reciprocating counterbalances and other moving parts. Biological clocks are equally complex, composed of multiple interacting genes that turn on or off in an orchestrated way to keep time during the day. In most organisms, biological clockworks are governed by a master clock, referred to as the "circadian oscillator," which keeps track of time and coordinates our biological processes with the rhythm of a 24-hour cycle of day and night. Life forms as diverse as humans, mice and mustard greens all possess such master clocks. And in the last decade or so, scientists have uncovered many of their inner workings, uncovering many of the genes whose cycles are tied to the clock and discovering how in mammals it is controlled by a tiny spot in the brain known as the "superchiasmatic nucleus." Scientists also know that in addition to the master clock, our bodies have other clocks operating in parallel throughout the day. One of these is the food clock, which is not tied to one specific spot in the brain but rather multiple sites throughout the body. The food clock is there to help our bodies make the most of our nutritional intake. It controls genes that help in everything from the absorption of nutrients in our digestive tract to their dispersal through the bloodstream, and it is designed to anticipate our eating patterns. Even before we eat a meal, our bodies begin to turn on some of these genes and turn off others, preparing for the burst of sustenance -- which is why we feel the pangs of hunger just as the lunch hour arrives. Scientist have known that the food clock can be reset over time if an organism changes its eating patterns, eating to excess or at odd times, since the timing of the food clock is pegged to feeding during the prime foraging and hunting hours in the day. But until now, very little was known about how the food clock works on a genetic level. What Ptacek and his colleagues discovered is the molecular basis for this phenomenon: the PKCγ protein binds to another molecule called BMAL and stabilizes it, which shifts the clock in time. The article, "PKCγ participates in food entrainment by regulating BMAL1" is authored by Luoying Zhang, Diya Abrahama, Shu-Ting Lin, Henrik Oster, Gregor Eichele, Ying-Hui Fu, and Louis J. Ptácek and appears in the Proceedings of the National Academy of Sciences. In addition to UCSF, authors on the study are affiliated with the Max Planck Institute of Biophysical Chemistry in Göttingen, Germany. This work was supported by the National Institutes of Health via grants #GM079180 and #708 HL059596, the Sandler Neurogenetics Fund, and the Howard Hughes Medical Institute. [B]Journal:[/B] L. Zhang, D. Abraham, S.-T. Lin, H. Oster, G. Eichele, Y.-H. Fu, L. J. Ptacek. PKC participates in food entrainment by regulating BMAL1. Proceedings of the National Academy of Sciences, 2012; 109 (50): 20679 DOI: [URL="http://dx.doi.org/10.1073/pnas.1218699110"]10.1073/pnas.1218699110[/URL] ============================================================ Source: [URL]http://www.sciencedaily.com/releases/2012/12/121224113351.htm[/URL] [/quote] -snip-
[QUOTE=Bradyns;38959986][editline] ^_^ [/editline] How is this late? This isn't the same news as [URL="http://www.facepunch.com/showthread.php?t=1234973"]the other post[/URL]. [URL="http://www.facepunch.com/member.php?u=467434"]Vodkavia[/URL], look things up before clicking. [editline] ^_^ [/editline] [B]They aren't even the same authors, or the same papers; why is this being rated late?[/B][/QUOTE] Because it's an article about clocks.
[QUOTE=Forumaster;38961911]Because it's an article about clocks.[/QUOTE] I just thought this was common knowledge.
I'm the one weird girl that turns down sweeties when I'm offered them.
[QUOTE=Forumaster;38961911]Because it's an article about clocks.[/QUOTE] I shall retreat to the cave from whence I came. :(
[QUOTE=Reshy;38962027]I'm the one weird girl that turns down sweeties when I'm offered them.[/QUOTE] If you decline sweets all the time you're p weird. But knowing your limits isn't weird.
[QUOTE=ZombieDawgs;38962135]If you decline sweets all the time you're p weird. But knowing your limits isn't weird.[/QUOTE] I don't like much cake and sweets in general.
I can't gain weight easily due to a fast metabolism. I always eat a snack when I get home from just about anything - does this effect that?
[QUOTE=geogzm;38988429]I can't gain weight easily due to a fast metabolism. I always eat a snack when I get home from just about anything - does this effect that?[/QUOTE] Shit, I barely fucking eat and still weigh 250. Always had a slow metabolism.
[QUOTE=Irkalla;38988448]Shit, I barely fucking eat and still weigh 250. Always had a slow metabolism.[/QUOTE] Get off your ass and move some yards.
[QUOTE=Irkalla;38988448]Shit, I barely fucking eat and still weigh 250. Always had a slow metabolism.[/QUOTE] Calories in, calories out. There's no way in hell your slow metabolism is the primary cause of that weight. You can continue to delude yourself and not face your problems or man the fuck up. [editline]27th December 2012[/editline] And this is coming from someone with an underactive thyroid. Even with it I manage to stay athletic. you have no excuses
Oh so this is why I'm gaining a bit of weight but it taste so good
[QUOTE=Irkalla;38988448]Shit, I barely fucking eat and still weigh 250. Always had a slow metabolism.[/QUOTE] [QUOTE=Strider*;38988717]Calories in, calories out. There's no way in hell your slow metabolism is the primary cause of that weight. You can continue to delude yourself and not face your problems or man the fuck up. [editline]27th December 2012[/editline] And this is coming from someone with an underactive thyroid. Even with it I manage to stay athletic. you have no excuses[/QUOTE] [QUOTE=Appolox;38988716]Get off your ass and move some yards.[/QUOTE] There is no reason to be aggressive to a comment. A mere innocent idle thought. I will not bore you with the list of medical problems that can prohibit exercise, I'll let you imagine other amazing reasons why, because they exist. Weight gain is not from lack of exercise, nor from eating. It is the storing of extra calories you intake that your body does not use. In other words, a guy who sits around and play games while eating an american diet of 2,000 is probably going to gain weight. Even if he is having a healthy diet. Infact, Michael Phelps the athlete eats 12,000 calories per day, and eats more than you, and I, even as an obese man, could physically handle. TL:DR, you're assumptive and aggressive people who are getting bent about an idle comment from a fat guy. A slow metabolism will result in weight gain because your body does not process as much as the guy with the fast one. So either exercise to use more calories, or eat less to reduce calorie intake. It's that simple, unlike you two I won't be making an assumption and let him live his life.
Fuckin body clocks. Sleep clock. Food clock.
clock blocked
Clocks everywhere. I love you FP
[QUOTE=doommarine23;38990043]There is no reason to be aggressive to a comment. A mere innocent idle thought. I will not bore you with the list of medical problems that can prohibit exercise, I'll let you imagine other amazing reasons why, because they exist. Weight gain is not from lack of exercise, nor from eating. It is the storing of extra calories you intake that your body does not use. In other words, a guy who sits around and play games while eating an american diet of 2,000 is probably going to gain weight. Even if he is having a healthy diet. Infact, Michael Phelps the athlete eats 12,000 calories per day, and eats more than you, and I, even as an obese man, could physically handle. TL:DR, you're assumptive and aggressive people who are getting bent about an idle comment from a fat guy. A slow metabolism will result in weight gain because your body does not process as much as the guy with the fast one. So either exercise to use more calories, or eat less to reduce calorie intake. It's that simple, unlike you two I won't be making an assumption and let him live his life.[/QUOTE] I can confirm this, I'll eat up to 5,000 calories some days but because I have an extraordinarily fast metabolism and do about 20 hours of sport a week ( 5 of which are intense training ) I still only weigh about 70kg (154lb ). Weight is also contributed on how you use your body. Being a roller skater my body knows it has to be able to burn stored calories fast, but then you compare someone who does a sport like Rugby their bodies need to burn the same amount of stored calories over a prolonged time.
my favorite song is clocks by coldplay
[QUOTE=doommarine23;38990043] Infact, Michael Phelps the athlete eats 12,000 calories per day, and eats more than you, and I, even as an obese man, could physically handle..[/QUOTE] Uh you do realize Michael Phelps outputs some ridiculous level of physical activity every day, we're talking HOURS every day in the pool and drilling technique and conditioning. His food intake is not a privilege it's a necessity for the level of physical activity he engages in if he doesn't want to get injured or burn out his nervous system. [editline]28th December 2012[/editline] most Olympic athletes engaged in events with any sort of power-speed component have some pretty ridiculous caloric intakes. People balk when they see these guys chowing down on mcdonalds for lunch and dinner and cry about how they must have good genetics to handle that "bad" food, they are not taking into account that fast food is literally one of the easiest methods to get the necessary calories in. Try eating 5000 calories of chicken breast and broccoli, you will struggle to get past 2000 calories I guarantee it.
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