SRT-1720 protects mice against obesity and extends life by 44 per cent - Polidicks

[RELEASE] [IMG]http://2.bp.blogspot.com/-yNCBWzBnxp8/Tk8XU992bSI/AAAAAAAAMWo/h2RfkEnkRXI/s1600/stt1720.jpg[/IMG] [I](a) Kaplan-Meier survival curves of mice fed a standard diet (SD) or a high-fat diet (HFD) supplemented with SRT1720 at either a low (HFD-L) or high (HFD-H) dose. Mean and maximum lifespan in weeks and the hazard ratio for mortality are represented below. In the parentheses the increases in maximum lifespan from birth and then diet onset are given. (b) Body weights of the groups over time, with average caloric intake over the course of the feeding study in the inset. Below are images of representative mice to illustrate phenotypic body mass of the groups at 82 weeks of age. (c) SRT1720 maintained normal liver appearance and reduced the onset of fatty liver as depicted by images of whole livers harvested after 12 weeks on diets and subsequent oil red O staining. Quantification of steatosis was performed by a blinded pathologist on livers from 82 week-old mice (26 weeks on diets; n = 6)[/I] [URL=http://www.nature.com/srep/2011/110818/srep00070/full/srep00070.html#/affil-auth]Scientific Reports - SRT1720 improves survival and healthspan of obese mice[/URL] [URL=http://www.nytimes.com/2011/08/19/science/19fat.html?_r=1]NY Times has coverage[/URL] [QUOTE]The drug, SRT-1720, protects the mice from the usual diseases of obesity by reducing the amount of fat in the liver and increasing sensitivity to insulin. These and other positive health effects enable the obese mice to live 44 percent longer, on average, than obese mice that did not receive the drug, according to a team of researchers led by Rafael de Cabo, a gerontologist at the National Institute on Aging. Despite the positive new results with SRT-1720, Sirtris is not putting it into clinical trials because the company believes another of its resveratrol mimics, SRT-2104, is more promising. That drug “is more suitable for human consumption,” said Dr. Sinclair, a co-author of Dr. de Cabo’s report. [/QUOTE] [QUOTE]Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by health benefits including reduced liver steatosis, increased insulin sensitivity, enhanced locomotor activity and normalization of gene expression profiles and markers of inflammation and apoptosis, all in the absence of any observable toxicity. Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1α-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals. [/QUOTE] [QUOTE]The current study shows that SRT1720, a member of a class of drugs that are in vitro Sirt1-activators, has a number of long-term benefits in mice that include shifting physiological parameters in mice consuming a high-fat diet towards those consuming a standard diet, modulating gene expression pathways associated with longevity, and improving overall health. These effects led to improvements in a variety of measures including survival, motor function, insulin sensitivity, organ pathology, and metabolic activity. With regards to energy metabolism, SRT1720 improved insulin sensitivity, maintained liver and pancreatic function, and prevented several metabolic changes associated with a high-fat diet. At the molecular level, SRT1720 reversed the gene expression profile induced by the high-fat diet with regards to markers of inflammation, apoptosis and oxidative stress. In vivo, SRT1720 promoted the deacetylation of hepatic PGC-1α, a known Sirt1 target that regulates mitochondrial biogenesis, stress resistance and survival35. In vitro, SRT1720-driven increases in cell survival and mitochondrial respiration were also Sirt1-dependent. While both mean and maximum lifespans were significantly extended in the mice, mean lifespan extension through reduction of premature death and increased healthspan was the most overt benefit of SRT1720 treatment. This is in agreement with a recent report where transgenic mice overexpressing Sirt1 displayed increased glucose tolerance and reduced susceptibility to induced tumors but not increased survival when fed a standard diet36. In the case of our mice, which were subjected to metabolic stress by the high fat diet, SRT1720 was able to dramatically shift the lifespan curves towards a more rectangular shape by acting to prevent premature death. Our results continue to support the beneficial pharmacological effect of SRT1720 in models of metabolic disease despite a recent report by Pacholec and colleagues to the contrary where the authors report 100 mg/kg SRT1720 is not tolerable and increases mortality in mice and that the compound does not elicit beneficial effects in the Lepob/ob mouse model of diabetes. This conclusion is inconsistent with not only our findings but also several additional studies where SRT1720 has been reported to exert positive effects in multiple models of metabolic disease including Lepob/ob mice11, diet-induced obese mice MSG-induced hypothalamic obese mice15 and Zucker fa/fa rats. Pacholec and colleagues did report that fasting insulin levels are reduced by SRT1720 administration, which is in agreement with our findings and with data reported previously in diet-induced obese mice11. The putative toxicity of SRT1720 administered at a 100 mg/kg oral dose to 8 mice over 18 days is inconsistent with a study where the compound exhibited no toxicity at a 5-fold higher dose for 15 weeks nor is it consistent with our long-term feeding study involving over 100 mice consuming an equivalent daily dose. In fact, our mice showed increased survival and improvement in multiple physiological parameters in response to SRT1720 treatment and did not display overt signs of toxicity even after more than 80 weeks of treatment.[/QUOTE] [/RELEASE] Source: [url]http://nextbigfuture.com/2011/08/srt-1720-protects-mice-against-obesity.html[/url]

I saved a mouse from my cat about an hour ago :unsmith:

Finally, I won't have to force my mouse to throw up after eating.

[img]http://filesmelt.com/dl/emot-science.gif[/img]

Now make it work on humans 96 year life expectancy, here we come

There is this bet going on between to scientists right know the each put in 100 dollars. the bet was whether or not will the be alive to claim the money in the next 150 years. also with interest rates it said the money will become like 100 million or something or 1 million I forgot what it was it was awhile ago.

Someone please tell me what those graphs mean in english? I understand the concepts of them but i want the logistics.

Too bad it's probably never going to get to humans. How many cures for cancer in mice do we have so far?

it may make you live longer but it'll probably make you grow an extra set of kidneys or something or it'll give you cancer always fucking cancer

[QUOTE=Atlascore;31836800]If it makes you grow an extra set of kidneys, isn't that a good thing? Especially if you drink alcohol?[/QUOTE] I'm pretty sure the liver processes alcohol. Though an extra-kidney would be useful too.

[h2]HUMAN TESTING[/h2]

15 years to human trials, 25 years to FDA approval, 35 years until patent monopoly is up and prices go below $10,000 a month. That's not going to help hardly anybody alive today. When real life-extending drugs become available, only the top 1% will have the money and means to use them. The rest will be left to get sick and die early, just like always.

[QUOTE=Atlascore;31837628]Oh bullshit. They'll make indefinitely more money if they sell it to the masses. Even if the top 1% was paying $10,000 a month they wouldn't be making as much if they had it at something like $100 a month and used by hundreds of millions of people.[/QUOTE] Right, because they totally made AIDS treatments accessible to everybody but the rich. :rolleyes:

Zombies.

[QUOTE=Used Car Salesman;31837653]Right, because they totally made AIDS treatments accessible to everybody but the rich. :rolleyes:[/QUOTE] Wait...AIDS treatments aren't for rich people only...and people always die of aids anyway

Very cool, but the only problem is, earth can't afford humans to live longer lives. Overpopulation and food shortages are already a problem now, and lowering the morality rate more is just going to make things worse. It totally sucks but its the truth.

[QUOTE=labbet;31837889]Very cool, but the only problem is, earth can't afford humans to live longer lives. Overpopulation and food shortages are already a problem now, and lowering the morality rate more is just going to make things worse. It totally sucks but its the truth.[/QUOTE] This. Also I don't want to end up living for too long.

[QUOTE=salty peanut v2;31835853]I saved a mouse from my cat about an hour ago :unsmith:[/QUOTE] There is tens of dead mouses all around my house.

[QUOTE=labbet;31837889]Very cool, but the only problem is, earth can't afford humans to live longer lives. Overpopulation and food shortages are already a problem now, and lowering the morality rate more is just going to make things worse. It totally sucks but its the truth.[/QUOTE] You're right, we need less humans. I volunteer you to lead this anti overpopulation revolution. [editline]20th August 2011[/editline] [QUOTE=FalcoLombardi;31837907]This. Also I don't want to end up living for too long.[/QUOTE] I wonder if you'll keep that opinion at your funeral. Oh wait.

[QUOTE=labbet;31837889]Very cool, but the only problem is, earth can't afford humans to live longer lives. Overpopulation and food shortages are already a problem now, and lowering the morality rate more is just going to make things worse. It totally sucks but its the truth.[/QUOTE] Unless they made it expensive to obtain.

[QUOTE=Mr. Scorpio;31838300]You're right, we need less humans. I volunteer you to lead this anti overpopulation revolution. [editline]20th August 2011[/editline] I wonder if you'll keep that opinion at your funeral. Oh wait.[/QUOTE] we all need to do our part in the Anti-Overpopulation Revolution by having one kid or less, or adopting kids!

It'll all go well until someone [U]fucks[/U] up. :v:

[QUOTE=Atlascore;31837706]Um, we don't have a cure for AIDS, and if we did it'd be available to EVERYONE, because they would make a grand total of $0 off keeping it for the rich only. I mean for fucks sake, rich people don't get AIDS. Go spew your anti-corporate bullshit somewhere else, you're making no sense.[/QUOTE]Aids "treatments", not cure.

How do I cook this shit?

The "extending life by 44%" refers to the results that showed that the mice treated with SRT1720 lived 44% longer than the [b]obese[/b] mice.

overpopulation is only a problem in uneducated societies. just look at italy

[QUOTE=Used Car Salesman;31837572]15 years to human trials, 25 years to FDA approval, 35 years until patent monopoly is up and prices go below $10,000 a month. That's not going to help hardly anybody alive today. When real life-extending drugs become available, only the top 1% will have the money and means to use them. The rest will be left to get sick and die early, just like always.[/QUOTE] Gross exaggeration. 15 years for a drug to reach market after lead molecule has been determined (including clinical trials and approval by whoever's in charge) and about 5 more years until patents run out. Prices will not be $10,000 a month because that is just bad business sense. We're not selling a life saving drug that's expensive to produce or has low demand here. This is a possible drug that might extend your life if you're getting too much fat in your diet. I think there is a huge market for that and it can afford to have reasonable prices.

snip

Jesus, look at those graphs! [editline]20th August 2011[/editline] Give this drug to me before I become obese.

Glorious fatster race.