• Potential Treatment For Internal Bleeding - Nanoparticle Emergency Clotting Coming Soon!
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[QUOTE]It sounds like science fiction: A bomb blast knocks a soldier to the ground. From the outside, they look fine, but internally they’re hemorrhaging as their internal organs bleed out. A medic appears on the scene and immediately administers an injection of nanoparticles that seek out the internal bleeding and help the blood to clot, saving the soldier's life. Well, it might not be science fiction for much longer. A team from [URL="https://www.vt.edu/"]Virginia Tech[/URL] and [URL="http://www.case.edu/"]Case Western Reserve University[/URL] have built on past research to create clot-promoting nanoparticles that are able to carry medicine directly to the site of injury, starting the healing process before a patient even leaves the battlefield or scene of an accident. Blast injuries—either from the pressure wave, flying shrapnel or being thrown to the ground—account for 79% of combat-related injuries, causing the brain, lungs, liver, and other organs to bleed uncontrollably. [URL="http://www.pnas.org/content/111/28/10293.full.pdf"]According[/URL] to the researchers, they started investigating the use of nanoparticles to treat hemorrhaging because “the shocking reality is that there are no treatments for internal bleeding.” “One cool thing about a nanoparticle is you can design it to actually seek out its target,” Pamela VandeVord, one of the researchers from Virginia Tech, told [URL="https://student.societyforscience.org/article/injected-nanoparticles-treat-internal-wounds"]Student Science[/URL]. Once injected, the particles enter the blood system where they seek out platelets, the cells in the blood responsible for clotting. When they find one, a chemical coating on the outside of the nanoparticle attaches to the surface of the platelet, joining the two. [B][U][URL="http://www.pnas.org/content/111/28/10293.full.pdf"]Previous research[/URL][/U][/B][B][U] has demonstrated how this action—the joining of the nanoparticle and platelet—increased survival rates from blast injuries in mice from 60% to a staggering 95%[/U][/B]. This [URL="http://pubs.acs.org/doi/abs/10.1021/acsmacrolett.5b00061"]new research[/URL], published in [I][URL="http://pubs.acs.org/journal/amlccd"]ACS Macro Letters[/URL][/I], shows that the benefit of these nanoparticles can be further enhanced by carrying with them anti-inflammatory steroids. After reaching the site of trauma, the nanoparticles naturally break down, releasing the drug directly at the site of injury.[/QUOTE] [URL="http://www.iflscience.com/health-and-medicine/nanoparticles-could-stop-internal-bleeding"]Source[/URL] Nano-science is fucking fantastic, this kind of medicine is quite literally 21st/future tech. I hope that one day an EMT/Combat Medic will be able to have this just as accessible as Adrenaline/Morphine/etc shots. Now I'm curious as to the safety of it considering it attaches to platelets, thus the obvious concern of blood vessel blockage.
[QUOTE=LoneWolf_Recon;47679772] Nano-science is fucking fantastic, this kind of medicine is quite literally 21st/future tech. I hope that one day an EMT/Combat Medic will be able to have this just as accessible as Adrenaline/Morphine/etc shots. Now I'm curious as to the safety of it considering it attaches to platelets, thus the obvious concern of blood vessel blockage.[/QUOTE] I am pretty sure this is one of the cases of "either we let you die on your own or give you this thing that might either kill you or save your life".
[QUOTE=Awesomecaek;47679790]I am pretty sure this is one of the cases of "either we let you die on your own or give you this thing that might either kill you or save your life".[/QUOTE] Agreed, mostly its speculation until more trials (human trials) are performed. Also we have no idea of the human immune response to them yet, but time will tell.
Any videos of them blowing up the rats? Sounds like an interesting experiment
This sounds like it might work for other conditions as well. I'm on anticoagulant medication that does't have an antidote yet (rivaroxaban), so this sounds like it might be useful for curing any internal bleeds it might cause.
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