Aspirin Doesn’t Just Cut Cancer Risk, It Stops It Spreading Too - Polidicks

[quote] Background Daily aspirin reduces the long-term incidence of some adenocarcinomas, but effects on mortality due to some cancers appear after only a few years, suggesting that it might also reduce growth or metastasis. We established the frequency of distant metastasis in patients who developed cancer during trials of daily aspirin versus control. Methods Our analysis included all five large randomised trials of daily aspirin (≥75 mg daily) versus control for the prevention of vascular events in the UK. Electronic and paper records were reviewed for all patients with incident cancer. The effect of aspirin on risk of metastases at presentation or on subsequent follow-up (including post-trial follow-up of in-trial cancers) was stratified by tumour histology (adenocarcinoma vs other) and clinical characteristics. Findings Of 17 285 trial participants, 987 had a new solid cancer diagnosed during mean in-trial follow-up of 6·5 years (SD 2·0). Allocation to aspirin reduced risk of cancer with distant metastasis (all cancers, hazard ratio [HR] 0·64, 95% CI 0·48—0·84, p=0·001; adenocarcinoma, HR 0·54, 95% CI 0·38—0·77, p=0·0007; other solid cancers, HR 0·82, 95% CI 0·53—1·28, p=0·39), due mainly to a reduction in proportion of adenocarcinomas that had metastatic versus local disease (odds ratio 0·52, 95% CI 0·35—0·75, p=0·0006). Aspirin reduced risk of adenocarcinoma with metastasis at initial diagnosis (HR 0·69, 95% CI 0·50—0·95, p=0·02) and risk of metastasis on subsequent follow-up in patients without metastasis initially (HR 0·45, 95% CI 0·28—0·72, p=0·0009), particularly in patients with colorectal cancer (HR 0·26, 95% CI 0·11—0·57, p=0·0008) and in patients who remained on trial treatment up to or after diagnosis (HR 0·31, 95% CI 0·15—0·62, p=0·0009). Allocation to aspirin reduced death due to cancer in patients who developed adenocarcinoma, particularly in those without metastasis at diagnosis (HR 0·50, 95% CI 0·34—0·74, p=0·0006). Consequently, aspirin reduced the overall risk of fatal adenocarcinoma in the trial populations (HR 0·65, 95% CI 0·53—0·82, p=0·0002), but not the risk of other fatal cancers (HR 1·06, 95% CI 0·84—1·32, p=0·64; difference, p=0·003). Effects were independent of age and sex, but absolute benefit was greatest in smokers. A low-dose, slow-release formulation of aspirin designed to inhibit platelets but to have little systemic bioavailability was as effective as higher doses. Interpretation That aspirin prevents distant metastasis could account for the early reduction in cancer deaths in trials of daily aspirin versus control. This finding suggests that aspirin might help in treatment of some cancers and provides proof of principle for pharmacological intervention specifically to prevent distant metastasis. Funding None.[/quote] [url]http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60209-8/fulltext[/url] Fuck yeah time to overdose myself

Wait, [B]17,285[/B] [I]P[/I]s or is that some kind of typo there?

[QUOTE=Vaught;35264376]Wait, [B]17,285[/B] [I]P[/I]s or is that some kind of typo there?[/QUOTE] European system?

[QUOTE=JoonazL;35264581]European system?[/QUOTE] There's no comma so I'm unsure if that 17 285 -> 17,285.

-snip- thinking of blood clots

[QUOTE=Vaught;35264591]There's no comma so I'm unsure if that 17 285 -> 17,285.[/QUOTE] Yeah, that's 17,285. Engineer's and many fields of scientists don't use commas because they're confusing. We use spaces instead.

What a breakthrough, surely the pharmaceutical companies will lower their prices to allow this to be available to everyone? :v:

[QUOTE=Master X;35266494]Yeah, that's 17,285. Engineer's and many fields of scientists don't use commas because they're confusing. We use spaces instead.[/QUOTE] Space makes me think it's two different numbers, engineers and scientist are confusing.

[QUOTE=Lukeo;35266539]What a breakthrough, surely the pharmaceutical companies will lower their prices to allow this to be available to everyone? :v:[/QUOTE] I'd consider it more likely that they increase the cost over such a thing, as it would likely increase demand substantially given that enough read it.

[QUOTE=Twistshock;35266610]I'd consider it more likely that they increase the cost over such a thing, as it would likely increase demand substantially given that enough read it.[/QUOTE] Was sarcasm babes Just highlighting how pharmaceutical companies are thieving bastards

[QUOTE=Dantai;35266584]Space makes me think it's two different numbers, engineers and scientist are confusing.[/QUOTE] Well the whole reason they use space is because some countries use commas where others use decimals. IIRC Google Search's calculator uses spaces.

But aspirin is already cheap and if a company increases prices they'll just be undercut. It also causes ulcers.

[QUOTE=Dantai;35266584]Space makes me think it's two different numbers, engineers and scientist are confusing.[/QUOTE] I'm fairly certain engineers use scientific notation.

I can see the marketing now. Aspirin 2.0, wonder drug of the 21st century.

5% of total P population isn't a whole lot, but it's breaking some ground. Just have to break open the analgesics to see just what part of the aspirin really kicks cancer to the curb.

Im allergic to aspirin [b]Well fuck.[/b]

[QUOTE=Dantai;35266584]Space makes me think it's two different numbers, engineers and scientist are confusing.[/QUOTE] Thing is there's not going to be any context in which you'd put down a number and another number just sitting there, hanging out.

[QUOTE=Xenocidebot;35268686]Thing is there's not going to be any context in which you'd put down a number and another number just sitting there, hanging out.[/QUOTE] 2 312 patient groups. Though admittedly that's a really shitty way to write something like that.

You would not do that with a comma either, you'd say "2 groups of 312 patients". Either way of writing it as you did, with a space or comma, will be confusing. Basic style errors fuck everything up. Plus, that's outside the context of an actual sentence. No one would ever just write "2 312 patient groups." in a technical document, it's just a fragment.

I usually put a period in between them, and use comma's for decimal numbers.

[QUOTE=Ryuken;35268520]Im allergic to aspirin [b]Well fuck.[/b][/QUOTE] I'm allergic to cancer

[QUOTE=Morbo!!!;35272471]I'm allergic to cancer[/QUOTE] Don't worry, death cures all allergies.

[QUOTE=mr apple;35272487]Don't worry, death cures all allergies.[/QUOTE] Well I'm allergic to dying, it has a chance of a fatal reaction.

[QUOTE=Coffee;35268076]I'm fairly certain engineers use scientific notation.[/QUOTE] For very large numbers that would be stupid to write out. 17 000 isn't hard, 5.62 * 10^18 is a very hard number to write out. (5 620 000 000 000 000 000)

And so we went from cancer-defying aspirins to discussing the way we write down large numbers.

[QUOTE=The Worm;35273166]For very large numbers that would be stupid to write out. 17 000 isn't hard, 5.62 * 10^18 is a very hard number to write out. (5 620 000 000 000 000 000)[/QUOTE] That's why they use NEF to write out larger numbers. Because as you pointed out, it's fucking awful to write them with spaces.