Scientists reactivate immune cells exhausted by chronic HIV - Polidicks

[release] [h2]Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have demonstrated why certain immune cells chronically exposed to HIV shut down, and how they can be reactivated. [/h2] Healthy B cells have a balanced mix of surface proteins that the immune system can use, like the gas pedal and brake of a car, either to activate the cell or to damp down its activity. However, in people with long-term HIV infection who have not begun antiretroviral therapy, their B cells—responsible for producing anti-HIV antibodies—display a surplus of inhibitory receptors, the surface proteins used to apply the brakes on a B cell. Scientists from the NIAID Laboratory of Immunoregulation led by Lela Kardava, Ph.D., Susan Moir, Ph.D., and Anthony S. Fauci, M.D., NIAID Director and Chief of the laboratory, wanted to know if this phenomenon can help explain why B cells become "exhausted" and essentially shut down in people who are HIV-infected but treatment-naive. To test their hypothesis, the scientists used molecules called small interfering RNAs (siRNAs), which acted at the genetic level to prevent exhausted B cells from replenishing inhibitory receptors. After treatment with siRNAs, the exhausted cells responded more normally to conditions that typically would spur a B cell into action, such as the presence of a virus, demonstrating that the excess of inhibitory receptors may explain why exhausted B cells are so unresponsive. Because B cells generally are difficult to manipulate, the new siRNA-based approach may hold promise for scientists seeking to develop therapies to improve the human antibody response against HIV and other pathogens by altering the expression of specific B-cell genes.[/release] [release]L Kardava et al. Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors. The Journal of Clinical Investigation DOI:10.1172/JCI45685 (2011).[/release] [url=http://medicalxpress.com/news/2011-06-scientists-reactivate-immune-cells-exhausted.html]Source[/url]

Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img]

[QUOTE=HazmatSquad;30232178]Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img][/QUOTE] That's HEV

[QUOTE=HazmatSquad;30232178]Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img][/QUOTE] hev you stupid son of a gun

Isn't this just because helper T Cells are destroyed and can't activate very many B Cells? Is there something I'm missing?

And then this will be forgotten about and we won't hear anything else about it for years.

[QUOTE=HazmatSquad;30232178]Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img][/QUOTE] [b]H[/b]azardous [b]E[/b]n[b]v[/b]ironment suit = HEV suit

Wow some people are getting bitchy over a intention joke.

[QUOTE=slashsnemesis;30237957]And then this will be forgotten about and we won't hear anything else about it for years.[/QUOTE] You won't hear about it because you don't have HIV and aren't following the companies research. Do either of those and you'll probably hear about it. [editline]4th June 2011[/editline] [QUOTE=xeonmuffin;30238196]Wow some people are getting bitchy [b]over a intention[/b] joke.[/QUOTE] Oh god oh man oh god oh man :derp: Please fix this I can't look away :ohdear:

[QUOTE=HazmatSquad;30232178]Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img][/QUOTE] Why in the actual fuck would Valve call it an HIV suit.

Maybe there's hope for my mother yet.

[QUOTE=Stinky;30239193]Why in the actual fuck would Valve call it an HIV suit.[/QUOTE] Wait, there is a non-actual fuck in which Valve would call it such a name!? GOD DAMMIT!!!!!!!!!!!!!

[QUOTE=HazmatSquad;30232178]Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img][/QUOTE] Hazardous Inviroment suit.

The H.E.V. thing going on in the thread is probably a reference to "Concerned: The Half-Life and Death of Gordon Frohman". [url]http://hlcomic.com/index.php?date=2005-08-10[/url] But that's just me. Oh well, you can always look back at the comic for nostalgia. I used to follow it when it first started being made. Oh, and cool they made a cure for AIDS praise da' lawd'. I'll see you in the year 2200 when you finally get made.

[QUOTE=HazmatSquad;30232178]Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img][/QUOTE] Well, actually it's a SUV suit.

[QUOTE=HazmatSquad;30232178]Doesn't Gordon wear HIV? :ohdear: [img]http://developer.valvesoftware.com/w/images/thumb/6/63/200px-Item_suit.jpg[/img][/QUOTE] safety first