[release]
ScienceDaily (Feb. 27, 2012) — Cells use various methods to break down and recycle worn-out components -- autophagy is one of them. In the dissertation she will be defending at Umeå University in Sweden, Karin Håberg shows that the protein SNX18 is necessary for cells to be able to perform autophagy.
In animal experiments on both simple organisms like fruit flies and in more complex animals like mice, researchers have seen that stimulating autophagy leads to increased longevity. It is still unclear whether these results are directly translatable to humans. However, there are theories that calorie restriction, which is a relatively well-established way of increasing longevity, induces higher levels of autophagy, which would help delay aging.
Cells metabolize their old proteins and cell organelles by breaking them down in a process called autophagy. The term comes from Greek and means roughly to eat oneself. Autophagy is important in cleaning out defective components that otherwise can damage cells and cause diseases.
Molecules that are to be broken down are enclosed in a membrane sack that forms an organelle called an autophagosome. This then merges with a lysosome, a cell organelle containing many different enzymes that are specialized in breaking down biomolecules. The metabolic products can then be recycled by the cells to form new molecules.
Karin Håberg's studies show that SNX18 binds to and can reshape cell membranes. Her studies of the role played by SNX18 in autophagy showed that when the cells' production of SNX18 was stopped by RNA interference, the number of autophagosomes declined drastically, thereby inhibiting the autophagy process.
When the cells were manipulated instead to overproduce SNX18, the number of autophagosomes increased. Karin Håberg was also able to demonstrate that it is precisely the capacity to re-model membranes that is the key to SNX18's function in the formation of autophagosomes. The studies of autophagy were conducted in collaboration with a research team at Oslo University led by Dr. Anne Simonsen.
Dissertation: [url]http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51999[/url][/release]
[url]http://www.sciencedaily.com/releases/2012/02/120227111202.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29[/url]
Yes please, and please don't disappear a week later.
[QUOTE=Daniel Smith;34920368][video=youtube;fdadZ_KrZVw]http://www.youtube.com/watch?v=fdadZ_KrZVw[/video][/QUOTE]
Heh, my mom did the translation for that into Chinese.
Please oh please let this protein be researched and used. Imagine living for 150-200 years...finally able to see space travel public.
[QUOTE=Neo222;34920515]Please oh please let this protein be researched and used. Imagine living for 150-200 years...finally able to see space travel public.[/QUOTE]
fuck that, once i'm 100 i'm out of here
[QUOTE=Neo222;34920515]Please oh please let this protein be researched and used. Imagine living for 150-200 years...finally able to see space travel public.[/QUOTE]
Or aliens
I don't want to live that old, honestly. Everything would hurt and I just generally don't want to see myself falling apart every morning knowing I might have another 50 or 100 years of this to go.
Why is everyone so obsessed with extending our life? What we should be focused on is curing the diseases that prevent people from living to be 50, let alone 15.
Over population is enough of an issue, and by 80 to 100 I feel you've lived plenty long enough to enjoy your life. This is such a selfish and unimportant goal to obtain at this point.
[QUOTE=Socram;34920860]Why is everyone so obsessed with extending our life? What we should be focused on is curing the diseases that prevent people from living to be 50, let alone 15.
Over population is enough of an issue, and by 80 to 100 I feel you've lived plenty long enough to enjoy your life. This is such a selfish and unimportant goal to obtain at this point.[/QUOTE]
Over Population?
[img]http://canaryinthecoalmine.typepad.com/.a/6a013487f321e0970c0148c813c564970c-800wi[/img]
I don't think I'll ever understand the people who are fine with just dying one day.
[QUOTE=Socram;34920860]Why is everyone so obsessed with extending our life? What we should be focused on is curing the diseases that prevent people from living to be 50, let alone 15.
Over population is enough of an issue, and by 80 to 100 I feel you've lived plenty long enough to enjoy your life. This is such a selfish and unimportant goal to obtain at this point.[/QUOTE]
There's a whole fucking galaxy out there. Let people have their wish.
[editline]29th February 2012[/editline]
This type of shit ALWAYS disappears. Especially the life extension stuff.
Overpopulation won't be an issue if they make sure that those who get an 'immortality' treatment cannot reproduce.
[QUOTE=Sottalytober;34920928]Over Population?
[img]http://canaryinthecoalmine.typepad.com/.a/6a013487f321e0970c0148c813c564970c-800wi[/img][/QUOTE]
I don't see very much tillable land, or drinkable water in that picture.
[QUOTE=Ardosos;34921007]I don't see very much tillable land, or drinkable water in that picture.[/QUOTE]
Neither is there in the heart of a city.
But you can find water underground if you drill long enough down, and many plants can be grown hydroponically.
[QUOTE=Ardosos;34921007]I don't see very much tillable land, or drinkable water in that picture.[/QUOTE]
Oh okay;
[IMG]http://paulbourke.net/miscellaneous/universe/fig1.gif[/IMG]
Do you see tillable land or drinkable water in there?
[QUOTE=Sottalytober;34920928]Over Population?
[img]http://canaryinthecoalmine.typepad.com/.a/6a013487f321e0970c0148c813c564970c-800wi[/img][/QUOTE]
recome to chinra
[IMG]http://us.acidcow.com/pics/20091222/crowded_train_stations_in_china_04.jpg[/IMG]
[QUOTE=Sickle;34921035]Oh okay;
[IMG]http://paulbourke.net/miscellaneous/universe/fig1.gif[/IMG]
Do you see tillable land or drinkable water in there?[/QUOTE]
Do you see any that can be reached within the span of several lifetimes?
[QUOTE=Angus725;34920461]Heh, my mom did the translation for that into Chinese.[/QUOTE]
thank you now i can sleep safely knowing that a facepuncher who i dont know's mother translated a movie that i've never seen into a language that i don't speak
[QUOTE=Van-man;34921031]Neither is there in the heart of a city.
But you can find water underground if you drill long enough down, and many plants can be grown hydroponically.[/QUOTE]
That wasn't my point. There aren't farms in a city, but you need farms to grow food for the population. Hydroponics aren't yet feasible on such a large scale.
[QUOTE=Ardosos;34921050]Do you see any that can be reached within the span of several lifetimes?[/QUOTE]
That's not the point. By the time this planet becomes overpopulated space travel will be feasible. It stupid as shit to assume it wouldn't. It could be discovered tomorrow.
[QUOTE=Sickle;34921093]That's not the point. By the time this planet becomes overpopulated space travel will be feasible. It stupid as shit to assume it wouldn't. It could be discovered tomorrow.[/QUOTE]
I hope you're right, as the planet could easily become overpopulated overnight as well.
[QUOTE=Kinglah Crab;34921052]thank you now i can sleep safely knowing that a facepuncher who i dont know's mother translated a movie that i've never seen into a language that i don't speak[/QUOTE]
I give thanks to the facepuncher's mother who translated this fine movie into a language i speak.
[QUOTE=Ardosos;34921161]I hope you're right, as the planet could easily become overpopulated overnight as well.[/QUOTE]
Bahahahaha.
[IMG]http://upload.wikimedia.org/wikipedia/commons/thumb/1/15/Countries_by_population_density.svg/800px-Countries_by_population_density.svg.png[/IMG]
Canada/Russia/South America/Australia/Scandinavia (Green/Iceland included kinda) are all safe.
The primary part of my argument was not that this will increase the rate of overpopulation (which it certainly would), an issue that, despite your pictures of desert and space, we are in fact facing.
I was mainly saying that there's hundreds of diseases and epidemics that prevent millions from reaching 80, let alone adulthood. We should be spending our money on curing these, before we waste our money trying to extend the lives of those that already live damn near perfect lives relative to the rest of the world. I.e. all of us.
I understand if you disagree, living to see space travel is pretty much on par with curing diseases.
[QUOTE=Socram;34921584]The primary part of my argument was not that this will increase the rate of overpopulation (which it certainly would), an issue that, despite your pictures of desert and space, we are in fact facing.
I was mainly saying that there's hundreds of diseases and epidemics that prevent millions from reaching 80, let alone adulthood. We should be spending our money on curing these, before we waste our money trying to extend the lives of those that already live damn near perfect lives relative to the rest of the world. I.e. all of us.
I understand if you disagree, living to see space travel is pretty much on par with curing diseases.[/QUOTE]
Why not have both? There's no reason that we as a massive species cannot take on more than one task or more than one major priority at a time. My argument is that it's unreasonable to insinuate that people who want to live forever are selfish. At the same time, I would love it to extend to every human being.
[QUOTE=Sickle;34921715]Why not have both? [/QUOTE]
I agree with Sickle, there's a reason why we have professionals in designated arts/schools around the world working on different things.
[h2]Autophagy has nothing to do with your lifespan[/h2]
[QUOTE=Ardosos;34921007]I don't see very much tillable land, or drinkable water in that picture.[/QUOTE]
Arizona River Project which directs water from the Colorado river runs through a large portion of the state. The Saguaro Cacti hold shit tons of water (It is a desert after all) - monsoon collections - farm land is abundant and the state itself is number 2 nationally in the production of a variety of fruits.
Childish but basic source
[url]http://www.agclassroom.org/kids/stats/arizona.pdf[/url]
[QUOTE=Arcana;34921041]recome to chinra
[IMG]http://us.acidcow.com/pics/20091222/crowded_train_stations_in_china_04.jpg[/IMG][/QUOTE]
[img]http://www.asianews.it/files/img/CHINA_Rural-China--.jpg[/img]
Welcome to rural china
[QUOTE=Helix Alioth;34921906][h2]Autophagy has nothing to do with your lifespan[/h2][/QUOTE]
thank god you bolded that otherwise i would've never known you had a baseless fact
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