• Strange Occurrences in the Metabolism of Various Psychoactives
    32 replies, posted
I think this thread is sincerely needed, as these kinds of occurrences are never talked about, or at least that I have seen. What I am speaking of is when your body metabolizes a drug in a very atypical and unexpected manner. I've had a good number of these kind of experiences, with all different kinds of drugs, and I do seem to metabolize some things quite differently from the "average" Caucasian male. However these types of events can happen to anyone, so its a VERY good reason to make sure to only "dip a toe in" when trying out new drugs, by dosing half or maybe even only 25% of the common threshold dose. The first time I had such an occurrence was about 6 years ago, the first time I tried Codeine. My dose; two Tylenol 4's, 120mg. I took them, and after about 2 hours I was pretty put off by the fact that I wasn't feeling anything, so I got out my lil one metal one hitter and smoked a good couple hits. Suddenly the Codeine kicked in after like 2 1/2 hours, (which is very odd, it normally should only take 30~ minutes) and I got high as a fucking kite. It's the highest I've ever been on opiates, even beating out all the times I insufflated the original OC40's and good tan and off white heroin. But before that I had tried taking anywhere from 3 to 5x 7.5/500 Lortabs and didn't feel anything. The second one and by far the most prominent in my memory, is also from about 6 years ago, when I took 300mg of DXM cough gels after having already tripped off them several times with doses as high as 600mg. The 300mg hit me WAY harder than even the 600mg, but it lasted only about 2 hours. However in those 2 hours I was so fucked up that it took me about 20 minutes to make it the 5 feet from my computer desk to my bed. And once I got into it, I laid there and wasn't able to see anything except white flashes. I had a very strange thought process in my mind at this time; I felt as though I was surely going to die, but somehow I was okay with it. It was either because I was so fucked up, or it was because I was also very depressed at that time, although probably a combo of the two factors. And then there are some other smaller incidents, such as what happened to me tonight, that spurred me to start this thread. I took 7x 10/325 norcos at about 5:30pm~ and I got very anxious and agitated because I still wasn't feeling anything after an hour when it normally only takes about half an hour to peak for me. 7 of those fuckers is $35, so you can see why it would upset me alot that I wasn't getting high. Well fast forward like 2 1/2 hours later, I started getting high, albeit not as high as I would've been if they had worked normally and kicked in fast. But still I got high after that long which was definitely both suprising and relieving. And this shit has happened a good handful of times with opiates for me, I can take them fucking 50 times, and then the 51st time they will randomly do shit like this... very odd. So basically just post your questions and experiences or anything related to this matter. I feel that we really need to raise awareness of these kinds of metabolic freak occurrences, which can result in unpleasant results anywhere from not getting high to straight up OVERDOSING and DYING because you metabolized it oddly.
[QUOTE=jonashappy;42625615]straight up OVERDOSING and DYING because you metabolized it oddly.[/QUOTE] Don't think anyone can post here if they have had that experience.
a valuable hypothesis.
[QUOTE=acommentator;42625703]Don't think anyone can post here if they have had that experience.[/QUOTE] Uhh, obviously haha... what I'm saying is people need to be aware of this so they can moderate their first dose accordingly.
Over the summer I took 25c twice two weeks apart(1mg) and the second time I also dose 600ug of 25i. 2 1/2 weeks after the second time I tried 600 ug of 25i and I never peaked. It was weird, the come up was normal, but I never got any visuals. All day I had mild psychedelic body high, and feeling that I was about to trip. Oddly enough, I got the absolute worst hppd I've ever had including light halos around all objects, angles feeling off, and a general feeling that I was dreaming. This lasted for a month and a half. Haven't touched rcs since and I think I won't for quite awhile
Word of advice: some drugs aren't pussies; sometimes [i]you're[/i] the pussy. I realized this when I ate a whole bunch of 2ce. I thought, "man, I'm tired of these weak ass trips off 1 tab of acid and all that. I just want to trip my sack off. 20mg is a 'strong' dose, I'm a man I can take it." And uh, cue the brain-rape. [sp]It might have been 30mg my scale is fucked[/sp]. If it was any other drug I'd done and I tripped that hard I would've cool with it but it was my first time doing it. And if there's anything that sucks its not liking a drug, and being on a whole bunch of it haha. So yeah, those little "test runs" are kind of gay and underwhelming, but jesus are they necessary sometimes.
This is why its always better to have less and be safe, Hero doses are for retards, no drug experience is worth a life unless you really need that next meth hit
One of the first times I took MDMA (not a lot), I got super surly, passed out for 5 minutes, woke up rolling intensely.
Lots of things can affect metabolism such as stomach contents and how active you've been during the day. Codeine is one of the most varied popular drugs in terms of metabolism due to CYP2D6 enzyme levels varying (sometimes wildly) among individuals. I don't think I've ever had a drug hit me a lot harder than I wanted it to as I always ensure I weigh powder out on a proper milligram scale. If it's a drug that is active in very low doses like 25i then you should dissolve it in large amounts of water to get an accurate idea as, scales tend to have a threshold before they become accurate.
[QUOTE=iwork3daysaweek;42627011]Word of advice: some drugs aren't pussies; sometimes [i]you're[/i] the pussy. I realized this when I ate a whole bunch of 2ce. I thought, "man, I'm tired of these weak ass trips off 1 tab of acid and all that. I just want to trip my sack off. 20mg is a 'strong' dose, I'm a man I can take it." And uh, cue the brain-rape. [sp]It might have been 30mg my scale is fucked[/sp]. If it was any other drug I'd done and I tripped that hard I would've cool with it but it was my first time doing it. And if there's anything that sucks its not liking a drug, and being on a whole bunch of it haha. So yeah, those little "test runs" are kind of gay and underwhelming, but jesus are they necessary sometimes.[/QUOTE] 2ce is pretty cool, but really weird and intense, music turned to colors, and i stepped on an xbox without even fuckin feeling it when i was on it. and i think that was only 15mg, 30 would be insane
[QUOTE=soupman345-2;42636150]2ce is pretty cool, but really weird and intense, music turned to colors, and i stepped on an xbox without even fuckin feeling it when i was on it. and i think that was only 15mg, 30 would be insane[/QUOTE] It was man. The crackling and buzzing noises I couldn't even tell were real or not. The whole room was tilting and twisting. I constantly felt like I was falling or accelerating forward and backward. Music was ridiculous. And the visuals were so prevalent I couldn't see shit in the dark. Also my nose started bleeding and I got blood all over myself. Later on I turned on a light and saw blood on my hands and I flipped my shit until I remembered why it was there. I also got attacked by a praying mantis and a bunch of moths that flew into the room.
[QUOTE=Mooman;42626411]Over the summer I took 25c twice two weeks apart(1mg) and the second time I also dose 600ug of 25i. 2 1/2 weeks after the second time I tried 600 ug of 25i and I never peaked. It was weird, the come up was normal, but I never got any visuals. All day I had mild psychedelic body high, and feeling that I was about to trip. Oddly enough, I got the absolute worst hppd I've ever had including light halos around all objects, angles feeling off, and a general feeling that I was dreaming. This lasted for a month and a half. Haven't touched rcs since and I think I won't for quite awhile[/QUOTE] I feel as though it would be a decent idea to back up his statements by saying that I dosed a very similar number of times with the same drugs, at the same time as he did, albeit on lower doses, and did not experience this hppd. I did get a very persistent itch underneath of my skin the day after dosing on the 25-i (600ug) and the 25-C (600ug). There was a fair amount of marijuana consumption as well, if I recall correctly. Mooman and I are quite different in fat makeup, and I'd say that I'm in better cardiovascular/respiratory health than he is, but other than that we are quite similar in our eating habits/sleep patterns etc.
There have been several times that I've had "hollow" experiences on DXM and shrooms. I'll take a normal dose (for me) and I'll feel the drug kick in, but the come-up is shallow and the effects never fully manifest. I'm left in a weird limbo headspace. I get time dilation, that sense of being removed from reality, the sense that something is "off" and that I should be tripping, but I just feel disoriented and hazy. Then I smoke.
[QUOTE=Anubis678;42639336]There have been several times that I've had "hollow" experiences on DXM and shrooms. I'll take a normal dose (for me) and I'll feel the drug kick in, but the come-up is shallow and the effects never fully manifest. I'm left in a weird limbo headspace. I get time dilation, that sense of being removed from reality, the sense that something is "off" and that I should be tripping, but I just feel disoriented and hazy. Then I smoke.[/QUOTE] I've also had similar experiences, I believe it's partially to do with your mindset. I've found that when I trip in a "casual" sense the effects aren't nearly as strong as the times when I go into it wanting to reach lala land, using similar doses. I'll end up in that off place you described. Offtopic but mobile posting is such a pain.
simplified formula: m*p=t m = mindset (scale of 0.1-1) p = psychedelic potential from the dose t = how tripped you are
When I toke my highs often come and go. Like, ill be high for 15 minutes after smoking then out of nowhere ill suddenly sober up, realize it, and within 15 seconds I'm already high again. This repeats occasionally throughout the rest of my high.
[QUOTE=valkery;42637546]I feel as though it would be a decent idea to back up his statements by saying that I dosed a very similar number of times with the same drugs, at the same time as he did, albeit on lower doses, and did not experience this hppd. I did get a very persistent itch underneath of my skin the day after dosing on the 25-i (600ug) and the 25-C (600ug). There was a fair amount of marijuana consumption as well, if I recall correctly. Mooman and I are quite different in fat makeup, and I'd say that I'm in better cardiovascular/respiratory health than he is, but other than that we are quite similar in our eating habits/sleep patterns etc.[/QUOTE] 1mg of 25c. And don't be hatin on my extremely [sp]un[/sp]healthy lifestyle
[QUOTE=mrmr;42639465]I've also had similar experiences, I believe it's partially to do with your mindset. I've found that when I trip in a "casual" sense the effects aren't nearly as strong as the times when I go into it wanting to reach lala land, using similar doses. I'll end up in that off place you described. Offtopic but mobile posting is such a pain.[/QUOTE] I disagree. Mindset has a substantially smaller impact on the effects one receives from drugs. Out of, say, 50 DXM trips, 2-4 were "hollow" without any discernible cause.
Drug dosages are strange. One day I was able to take 20mg of oxy and be high as shit all day, and the next day I could take 50mg with 20mg valium and 20mg DPH and feel completely sober. The day after that I could take 30mg oxy and feel high as fuck. Drugs are strange, and everyone should treat them as an experimental and positive additive to their life, not as a curse or addiction.
[QUOTE=AppleJackson;42661589]Drug dosages are strange. One day I was able to take 20mg of oxy and be high as shit all day, and the next day I could take 50mg with 20mg valium and 20mg DPH and feel completely sober. The day after that I could take 30mg oxy and feel high as fuck. Drugs are strange, and everyone should treat them as an experimental and positive additive to their life, not as a curse or addiction.[/QUOTE] Don't know much but isnt that because of drug tolerance? Like when you take lsd it will be dulled if you take it again really soon?
[QUOTE=acommentator;42670054]Don't know much but isnt that because of drug tolerance? Like when you take lsd it will be dulled if you take it again really soon?[/QUOTE] Not really, if you know what numbers are you can see those dosages are all over the place.
I had lifelike hallucinations my first time on M, guess that isn't supposed to happen!
You do low doses because of the potential for allergic reactions, your body metabolizes drugs like every other body unless you have some undiagnosed medicinal condition. I think you underestimate how much set & settings affect your high. (this is not only related to psychedelics)
[QUOTE=AppleJackson;42661589]Drugs are strange, and everyone should treat them as an experimental and positive additive to their life, not as a curse or addiction.[/QUOTE] I love you
[QUOTE=kaskade700;42673803]your body metabolizes drugs like every other body unless you have some undiagnosed medicinal condition. [/QUOTE] Not true.
[QUOTE=kaskade700;42673803]You do low doses because of the potential for allergic reactions, your body metabolizes drugs like every other body unless you have some undiagnosed medicinal condition. I think you underestimate how much set & settings affect your high. (this is not only related to psychedelics)[/QUOTE] Some people have different levels of enzymes, stronger or weaker stomach acid, different concentrations of receptors or dicferent chemical levels in the brain, etc. There are a TON of variables.
[QUOTE=Anubis678;42673867]I love you[/QUOTE] Well thank you. A lot of people tend to think drugs have a set amount you need to take to feel a certain way, and that drugs will always do the same thing just because their researched and well known, but drugs are weird by nature and you can't always predict how it's going to be.
[QUOTE=iwork3daysaweek;42627011]Word of advice: some drugs aren't pussies; sometimes [i]you're[/i] the pussy. I realized this when I ate a whole bunch of 2ce. I thought, "man, I'm tired of these weak ass trips off 1 tab of acid and all that. I just want to trip my sack off. 20mg is a 'strong' dose, I'm a man I can take it." And uh, cue the brain-rape. [sp]It might have been 30mg my scale is fucked[/sp]. If it was any other drug I'd done and I tripped that hard I would've cool with it but it was my first time doing it. And if there's anything that sucks its not liking a drug, and being on a whole bunch of it haha. So yeah, those little "test runs" are kind of gay and underwhelming, but jesus are they necessary sometimes.[/QUOTE] I did the same thing when trying DXM for the first time. I planned on going for a low second plat, which wouldve been about half a bottle. Downed it, waited like 1-2 hours and felt nothing so I said fuck it and downed the rest of the bottle which put me at a high second, low third. Only like 30min-1 hour later I started getting nauseous and i vomited a bit, which is to be expected. However after I finished vomiting I got severe spins and felt sick to my stomach. It started to hit hard as I felt like I was watching myself sitting on the bench with my head down toward my knees. My body felt like a puppet as my 'mind' was controlling it like a marionette. After my friend brought me a bit of bread to settle my stomach I started to turn around and music became amazing and time slowed beyond I have ever felt before (5 minutes felt like an hour I watched an 24 min episode of cowboy bebop and it felt like a full length movie... no i did not stupidly watch the actual cowboy bebop movie). I've learned my lesson not to go all in on your first dose with a new drug.
[QUOTE=AppleJackson;42676322]Well thank you. A lot of people tend to think drugs have a set amount you need to take to feel a certain way, and that drugs will always do the same thing just because their researched and well known, but drugs are weird by nature and you can't always predict how it's going to be.[/QUOTE] Whilst that's true for psychedelics, I'd say you can be pretty sure what opiates, benzos and stimulants are going to do if you've had experience with them.
I'd go so far as to say that a lot of "allergic reactions" that people have with pharmaceuticals are simply just cases of someone who has just the right enzymes to hyper-metabolize something and therefor get far too strong of a dose from what would be a normal or even weak dose for the average population. One example of this that I can think of is how they make 2.5/325 hydrocodone compound pills, for 90% of the population a standard 5mg pill would be just right or too little; but for a select group of the populace, 2.5mg could act how 10mg does in other people.
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