Nicotine vaccine prevents nicotine from reaching the brain - Polidicks

[quote] The Boston-based start-up company Selecta Biosciences has tested the SEL-068 vaccine in the lab and is beginning safety tests in humans, making SEL-068 the first synthetic nanoparticle vaccine to be tested in human clinical trials. If successful, the vaccine would be the first synthetically engineered nanoparticle vaccine, distinct from conventionally manufactured biological vaccines. Although nicotine is not a virus, the nanoparticles target the chemical as if it were by initiating an immune response. Selecta is using the same strategy to design other synthetic vaccines for non-virus ailments including malaria, cancer, diabetes, and transplant rejection. Once a person receives the nicotine vaccine, the effects should last for several years. While other smoking aids such as the patch and gum interfere with nicotine cravings by delivering small amounts of nicotine, the vaccine does not try to reduce cravings. Instead, it makes smokers unable to alleviate their cravings by smoking. However, the company notes that smoking several cigarettes in a row could overwhelm the immune system so that a few nicotine molecules could reach the brain and deliver a mild effect. People spend more than $2 billion per year on smoking aids and drugs, although these strategies are ineffective for many people and can have severe side effects. Selecta expects to have results from its early trials in humans this summer, and if the nanoparticles are well-tolerated in humans, will continue with further testing.[/quote] [url]http://medicalxpress.com/news/2012-05-nicotine-vaccine-brain.html[/url]

Nicotine ain't even addicting alone really but I guess what works works.

[QUOTE=Chicken_Chaser;35804004]Nicotine ain't even addicting alone really but I guess what works works.[/QUOTE] Do you..- what. Nicotine is the thing that keeps people addicted to tobacco. This 'vaccine' will rid smokers (if chosen) of their addiction to tobacco.

[QUOTE=areolop;35804024]Do you..- what. Nicotine is the thing that keeps people addicted to tobacco. This 'vaccine' will rid smokers (if chosen) of their addiction to tobacco.[/QUOTE] If you started with vaping and don't smoke cigs it's easy to stop. What makes it addicting is some of the added shit in cigs. Nicotine by itself isn't really addicting.

[QUOTE=areolop;35804024]Do you..- what. Nicotine is the thing that keeps people addicted to tobacco. This 'vaccine' will rid smokers (if chosen) of their addiction to tobacco.[/QUOTE]The vaccine won't get rid of the addiction immediately however. It will make it so you can't satisfy the addiction with tobacco since nicotine will no longer be able to reach the brain. However according to the article if you smoke enough cigarettes in a row some of the nicotine will bypass the effect.

[QUOTE=Boxbot219;35804065] However according to the article if you smoke enough cigarettes in a row some of the nicotine will bypass the effect.[/QUOTE] In other words it doesn't do shit for those who really need it.

[QUOTE=Chicken_Chaser;35804061]If you started with vaping and don't smoke cigs it's easy to stop. What makes it addicting is some of the added shit in cigs. Nicotine by itself isn't really addicting.[/QUOTE] The fuck are you smoking?

Okay, so here's what we do. Rid the house of all the cigs, drain the gas tank, and vaccinate the victim. Oh and then flee to minimum safe distance, shit's gonna get ugly. [editline]3rd May 2012[/editline] [QUOTE=Hysteric;35804126]The fuck are you smoking?[/QUOTE] electric cigs apparently.

[QUOTE=Chicken_Chaser;35804061]If you started with vaping and don't smoke cigs it's easy to stop. What makes it addicting is some of the added shit in cigs. Nicotine by itself isn't really addicting.[/QUOTE] [quote=Wikipedia]Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae); biosynthesis takes place in the roots and accumulation occurs in the leaves. It constitutes approximately 0.6–3.0% of the dry weight of tobacco and is present in the range of 2-7 µg/kg of various edible plants. It functions as an antiherbivore chemical; therefore, nicotine was widely used as an insecticide in the past and nicotine analogs such as imidacloprid are currently widely used. In low concentrations (an average cigarette yields about 1 mg of absorbed nicotine), the substance acts as a stimulant in mammals, while high concentrations (30-60 mg) can be fatal. [B]This stimulant effect is the main factor responsible for the dependence-forming properties of tobacco smoking.[/B] [B]According to the American Heart Association, nicotine addiction has historically been one of the hardest addictions to break, while the pharmacological and behavioral characteristics that determine tobacco addiction are similar to those determining addiction to heroin and cocaine.[/B] The nicotine content of popular American-brand cigarettes has slowly increased over the years, and one study found that there was an average increase of 1.6% per year between the years of 1998 and 2005. This was found for all major market categories of cigarettes. Research in 2011 has found that nicotine inhibits chromatin-modifying enzymes (class I and II histone deacetylases) which increases the ability of cocaine to cause an addiction.[/quote] [url]http://en.wikipedia.org/wiki/Nicotine[/url]

and now to never hear of it again. [editline]3rd May 2012[/editline] [QUOTE=Chicken_Chaser;35804061]If you started with vaping and don't smoke cigs it's easy to stop. What makes it addicting is some of the added shit in cigs. Nicotine by itself isn't really addicting.[/QUOTE] I'm pretty sure that tar isn't what gets you addicted to smoking cigarettes. You are one poor, misinformed man.

Shit will get seriously ugly when you give someone this shot, I kinda see how it works for leaving cigs but it sounds like detoxing, which is fucking terrible for the duration of the detox.

[QUOTE=latin_geek;35804497]Shit will get seriously ugly when you give someone this shot, I kinda see how it works for leaving cigs but it sounds like detoxing, which is fucking terrible for the duration of the detox.[/QUOTE] Except instead of OH GOD THIS IS TERRIBLE it's oh man I've been without a smoke for a week this feels pretty bad.

[QUOTE=Falchion;35804585]Except instead of OH GOD THIS IS TERRIBLE it's oh man I've been without a smoke for a week this feels pretty bad.[/QUOTE] Not really. According to the article quitting smoking will still feel equally as horrible as doing it without the vaccine.

[QUOTE=Atlascore;35804553]I wish people would stop with this bullshit. This isn't another cancer cure, it's something completely different, this wouldn't harm pharmaceutical companies profits at all, in fact they would gain profits from it, plus cigarette companies are completely powerless to stop something like this.[/QUOTE] I'm just going to point out that there's probably a million better reasons we don't hear any more of "cancer cures" than this pharmaceutical company conspiracy theory.

Wouldn't a lot of cigarette making companies try to get this outlawed or something?

[QUOTE=Banhfunbags;35804656]Wouldn't a lot of cigarette making companies try to get this outlawed or something?[/QUOTE] Considering the government already drowns cigarette sales with taxes as a method to try to prevent people from smoking I somehow really doubt that they would manage to outlaw this.

Okay well what about the nicotine that our brains naturally produce? Does it inhibit that too, because that sounds counter-productive. Cure an addiction by shutting down a natural process in the brain. Here's a solid way to quit smoking. STOP SMOKING. People make it out to be the hardest thing in the world. Well something those people don't seem to understand, no matter how you word it or how many times you say it, the only thing that makes it hard is the fact that you make it seem so hard. Some people need help, I get that. It's not easy to quit. But to treat it as some kind of disease by making a vaccine for it is a little much I think.

[QUOTE=Boxbot219;35804649]Not really. According to the article quitting smoking will still feel equally as horrible as doing it without the vaccine.[/QUOTE] exactly this forces you to quit smoking by cutting off that pleasant and addiction-fullfilling feel you get when you smoke it must feel fucking horrible to desperately smoke a cig a couple days into the vaccine and finding out it does nothing to you

I've been smoking for 3 years now and I hate it more every day. Patches and gum do nothing and I'm allergic to the pills which make you feel like throwing up every time you smoke. Quitting it'self isn't that bad but having the willpower to push yourself through a week of constantly feeling like a ciggy and then months of on and off cravings is really hard, especially if you can access them easily. It's like being hungry but forcing yourself not to eat with a jar of cookies right in front of you. This would be effective for me because once you get it there's no going back, it forces you to deal with the cravings.

[QUOTE=Jurikuer;35804712]Okay well what about the nicotine that our brains naturally produce? Does it inhibit that too, because that sounds counter-productive. Cure an addiction by shutting down a natural process in the brain. Here's a solid way to quit smoking. STOP SMOKING. People make it out to be the hardest thing in the world. Well something those people don't seem to understand, no matter how you word it or how many times you say it, the only thing that makes it hard is the fact that you make it seem so hard. Some people need help, I get that. It's not easy to quit. But to treat it as some kind of disease by making a vaccine for it is a little much I think.[/QUOTE] You don't seem to understand how bad nicotine addiction can actually be. It's easy enough to just tell someone to simply stop smoking. But if it was that easy then why do so few smokers ever actually quit despite the inherent health problems smoking causes?

That's not how an addiction works. Even with the vaccine I can see this failing. Just because you don't get that addictive good feeling from your smoking anymore doesn't mean you're not going to want it. In fact, it may make things worse! Your brain may feel the need to over compensate by making the craving worse. But at the same time, some people might be the polar opposite and instead no longer get that good feeling anymore and become bored of it, ultimately turning them off from it. It's a hit or miss really, and like any other cure to an addiction, it depends entirely on the person.

[QUOTE=Jurikuer;35804770] Just because you don't get that addictive good feeling from your smoking anymore doesn't mean you're not going to want it. In fact, it may make things worse! [/QUOTE] If that's the case then why are you suggesting that the solution would be to just stop smoking?

[QUOTE=Boxbot219;35804785]If that's the case then why are you suggesting that the solution would be to just stop smoking?[/QUOTE] Because that's how you stop the cravings. What kind of a question is that? And Atlascore apparently agrees with your inability to understand whats good for you.

Doesn't this already exist on the market? Or am I missing something? I can't remember what it's called right now, but I was sure it already existed.

[QUOTE=Jurikuer;35804848]Because that's how you stop the cravings. What kind of a question is that?[/QUOTE] Actually, the best way is to slowly step down your nicotine intake, until there's practically no difference between getting your daily nicotine fix, and not.

[QUOTE=Jurikuer;35804848]Because that's how you stop the cravings. What kind of a question is that? And Atlascore apparently agrees with your inability to understand whats good for you.[/QUOTE] Oh my bad. I guess you know what's good for anyone who can't find the willpower to stop smoking on their own.

[QUOTE=Atlascore;35804553]I wish people would stop with this bullshit. This isn't another cancer cure, it's something completely different, this wouldn't harm pharmaceutical companies profits at all, in fact they would gain profits from it, plus cigarette companies are completely powerless to stop something like this.[/QUOTE] You ALWAYS read about these miracle solutions to everything, not just cancer. They never stick around though, and i doubt it's because of your theory. here's a report from 2 years ago that is almost the same as this report [url]http://articles.cnn.com/2010-04-21/health/nicotine.vaccine.nicvax_1_nicvax-nicotine-vaccine-zyban?_s=PM:HEALTH[/url] Now, until i brought this up, did you ever hear of this?

Finally some good news! I've been trying to quit for years.

[QUOTE=mysteryman;35805140]You ALWAYS read about these miracle solutions to everything, not just cancer. They never stick around though, and i doubt it's because of your theory. here's a report from 2 years ago that is almost the same as this report [URL]http://articles.cnn.com/2010-04-21/health/nicotine.vaccine.nicvax_1_nicvax-nicotine-vaccine-zyban?_s=PM:HEALTH[/URL] Now, until i brought this up, did you ever hear of this?[/QUOTE]Are you aware that drugs and vaccines can take anywhere up to 25 years to bring to market due to stringent safety procedures and tests? Even though the article you mentioned said they're in phase III trials, they've still got a while to go.

[QUOTE=Boxbot219;35804680]Considering the government already drowns cigarette sales with taxes as a method to try to prevent people from smoking I somehow really doubt that they would manage to outlaw this.[/QUOTE] The government does it this way to make you think they care about your health, they probably laugh while rolling in the cash smokers give to the government each year. I agree it does prevent some people, but if everyone suddenly gave up smoking they'd be all "oh fuck."