[quote]New research, published today in the journal [I]Science[/I], reveals that a type of stromal cell found in many cancers which expresses fibroblast activation [URL="http://www.physorg.com/tags/protein/"]protein[/URL] alpha (FAP), plays a major role in suppressing the [URL="http://www.physorg.com/tags/immune+response/"]immune response[/URL] in cancerous tumours – thereby restricting the use of vaccines and other therapies which rely on the body's immune system to work. They have also found that if they destroy these [URL="http://www.physorg.com/tags/cells/"]cells[/URL] in a tumour immune suppression is relieved, allowing the immune system to control the previously uncontrolled tumour. Douglas Fearon, Sheila Joan Smith Professor of Immunology of the Department of Medicine at the University of Cambridge, said: "Finding the specific cells within the complex mixture of the cancer stroma that prevents immune killing is an important step. Further studying how these cells exert their effects may contribute to improved immunological therapies by allowing us to remove a barrier that the cancer has constructed."
Vaccines created to prompt the [URL="http://www.physorg.com/tags/immune+system/"]immune system[/URL] to attack cancerous cells in tumours have shown to activate an immune response in the body but have, inexplicably, almost never affected the growth of tumours. Immunologists who specialise in tumours have suspected that within the tumour microenvironment the activity of immune cells is somehow suppressed, but they have thus far been unable to fully reverse this suppression.
The new research, funded by the Wellcome Trust and the Sheila Joan Smith Professorship endowment, sheds light on why the immune response is suppressed. The Cambridge study found that at least one immune suppressive component is contained within normal tissue cells (called stromal cells) the cancer has coerced to assist its survival. The cell they studied specifically expresses a unique protein often associated with wound healing - fibroblast activation protein alpha (FAP). The FAP expressing cells are found in many cancers, including breast and colorectal cancers.
In order to determine if FAP expressing stromal cells contribute to the resistance of a tumour to vaccination, the researchers created a transgenic mouse model which allowed them to destroy cells which expressed FAP. When FAP-expressing cells were destroyed in tumours in mice with established Lewis lung carcinomas (of which only 2% of the tumour cells are FAP-expressing), the cancer began to rapidly 'die'. The Fearon lab now hopes to collaborate with scientists at the CRUK Cambridge Research Institute to evaluate the effects of depleting FAP-expressing cells in a mouse model that more closely resemble human cancer, and to examine FAP-expressing cells of human tumours.
Professor Fearon continued: "These studies are in the mouse, and although there is much overlap between the mouse and human immune systems, we will not know the relevance of these findings in humans until we are able to interrupt the function of the tumour stromal cells expressing FAP in patients with cancer.
"It should be noted, however, that the FAP-expressing stromal cell was actually first found in human [URL="http://www.physorg.com/tags/cancer/"]cancer[/URL] by Lloyd Old and his colleagues 20 years ago."[/quote]
[url=http://www.physorg.com/news/2010-11-breakthrough-cancer-vaccine.html]Source[/url]
Ah, so I just have to fap a lot.
"The FAP expressing cells are found in many cancers, including [i]breast[/i] and colorectal cancers." :D
You got cancer baby?
Come here and let me cure that for you...
With all of the 'breakthroughs' that pop up in the news every now and then, you think they would have cured at least some forms of cancer by now.
I feel like this thread title happens every 2 weeks now. Strangely cancer still exists...
[QUOTE=Jewsus;25863394]I feel like this thread title happens every 2 weeks now. Strangely cancer still exists...[/QUOTE]
Because it's not in big pharma's best interest to cure it since simply treating it is far more profitable.
No, because these have to be thoroughly tested to make sure they are reasonable safe.
"Congratulations! We cured your cancer but now you'll have bladder control problems and renal failure. But at least your cancer is gone!"
It can take ten years if everything goes right. And if it is shown that something is wrong, they have to go back several steps to try to fix it, potentially delaying it several years.
[QUOTE=Kuro.;25863475]Because it's not in big pharma's best interest to cure it since simply treating it is far more profitable.[/QUOTE]
It's a conspiracy maaaannn!
[QUOTE=Kuro.;25863475]Because it's not in big pharma's best interest to cure it since simply treating it is far more profitable.[/QUOTE]
We've been able to cure death for years now too, but the bigwigs in the coffin industry suppressed the news. Those greedy fat-cats.
[QUOTE=Kuro.;25863475]Because it's not in big pharma's best interest to cure it since simply treating it is far more profitable.[/QUOTE]
I feel sorry for you if you actually believe this
[QUOTE=Kuro.;25863475]Because it's not in big pharma's best interest to cure it since simply treating it is far more profitable.[/QUOTE]
Monopolizing a market and potentially shutting out other major competitors out of the newly created market is not profitable?
Well, looks like its back to Econ 101
People do actually believe that Big Pharma bullshit, it's pretty sad
[editline]4th November 2010[/editline]
[QUOTE=Kuro.;25863475]Because it's not in big pharma's best interest to cure it since simply treating it is far more profitable.[/QUOTE]
An idea created by a 18~ year old student that hasn't taken an economics class in his life, and who's overall understanding of the workings of a private corporation is nil
Not saying I have any, but I know enough to understand that a company would love to fuck its competition over by bringing in a cure for the worst disease EVER. It's kinda the plus to capitalism, big advancements come faster because of the want to kick other competition's ass.
[QUOTE=Tetracycline;25864127]People do actually believe that Big Pharma bullshit, it's pretty sad
[editline]4th November 2010[/editline]
An idea created by a 18~ year old student that hasn't taken an economics class in his life, and who's overall understanding of the workings of a private corporation is nil
Not saying I have any, but I know enough to understand that a company would love to fuck its competition over by bringing in a cure for the worst disease EVER. It's kinda the plus to capitalism, big advancements come faster because of the want to kick other competition's ass.[/QUOTE]
Obviously the very tippy-tops of the pharmaceutical companies have secretive meetings in volcano-lairs bi-annually to arrange mutually beneficial business plans. If one company came forth and tried to claim stakes to the cure for cancer, the CEOs of the others would be forced to tie him to a hank of beef and feed him to genetically-enhanced, cancer-free sharks. Probably while chanting.
Same people who believe that vaccines are a conspiracy.
[editline]5th November 2010[/editline]
[QUOTE=Tetracycline;25864127]It's kinda the plus to capitalism, big advancements come faster because of the want to kick other competition's ass.[/QUOTE]
Yeah. When your income is based on your ability to stay ahead of everyone else, advancements are the best options.
[QUOTE=Jewsus;25863394]I feel like this thread title happens every 2 weeks now. Strangely cancer still exists...[/QUOTE]
Diseases are rarely cured overnight. I think they are coming with more breakthroughs because stem cell research is being funded.
So if I FAP on a patient, they're cured? Sweet.
[QUOTE=faze;25868109]So if I FAP on a patient, they're cured? Sweet.[/QUOTE]
Every man on the planet needs to join hands to stop cancer
[QUOTE=BreenIsALie;25868117]Every man on the planet needs to join hands to stop cancer[/QUOTE]
:love:
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