Scientists ID the little bastard molecule responsible for causing feelings of stress, anxiety and de - Polidicks

[url]http://www.independent.co.uk/news/science/scientists-discover-the-molecule-responsible-for-causing-feelings-of-depression-8724471.html[/url] [quote] Scientists have used one of the world’s most powerful X-ray machines to identify the molecule responsible for feelings of stress, anxiety and even depression. ... However, scientists have now discovered that the protein receptor CRF1 is responsible for releasing hormones which can cause anxiety and depression over extended periods of time. The protein receptor is found in the brain and controls our response to stress. When it detects stress molecules released by the hypothalamus, it releases these hormones. ... [B] The information gained from this study will be used to design small molecule drugs that fit into this new pocket to treat depression.[/B] Speaking to the [I]Sunday Times[/I], Dr Fiona Marshall, Chief Scientific Officer at Heptares Therapeutics, said: “[B]Now we know its shape, we can design a molecule that will lock into this crevice and block it so that CRF1 becomes inactive — ending the biochemical cascade that ends in stress[/B].” Writing on Diamond’s website, Dr. Andrew Dore, a senior scientist with Heptares added that the structure of the protein receptor “can be used as a template to solve closely related receptors that open up the potential for new drugs to treat a number of major diseases including Type 2 diabetes and osteoporosis”.[/quote]

Nice! Can I get me some of that molecule and weaponize it. My foes will kneel over and weep - the next step in non-lethal warfare.

[QUOTE=Moupi;41575445]Nice! Can I get me some of that molecule and weaponize it. My foes will kneel over and weep - the next step in non-lethal warfare.[/QUOTE] Are you Zod?

Now find whatever causes procrastination pls

Our bodies respond to stress in such a stupid way. Seriously, shutting yourself in a cave and pretending that the lion outside doesn't exist while bawling your eyes out about the inevitability of your death is one of the most idiotic survival mechanisms ever.

If they blocked the receptors with a drug, wouldn't that make it all the worse once you get off the drug?

[QUOTE=qwerty000;41575505]Now find whatever causes procrastination pls[/QUOTE] Low serotonin and dopamine levels which are generally exhausted by stress hormones in the OP.

[QUOTE=Starpluck;41575538]Low serotonin and dopamine levels which are generally exhausted by stress hormones in the OP.[/QUOTE] Ok. Let me rephrase it. Gimme the pill that gets rid of it :v:

[QUOTE=qwerty000;41575505]Now find whatever causes procrastination pls[/QUOTE] They can get to that later I'm sure.

So what this is effectively saying is that, one day, you'll literally be able to take a chill pill?

I get the feeling that even if they did produce a pill or something that simply did just that and made you feel better, it'd be a controlled substance and not just readily available for purchase; if for no reason other than "Not everyone can afford it and it'd make an unfair advantage!" or some other stupid shit.

[QUOTE=sltungle;41575608]So what this is effectively saying is that, one day, you'll literally be able to take a chill pill?[/QUOTE] It's called Xanax.

[QUOTE=sltungle;41575608]So what this is effectively saying is that, one day, you'll literally be able to take a chill pill?[/QUOTE] we've been taking chill pills for a long time

Wouldnt get too excited just yet. Scientists have a bad habit of being overly enthusiastic with their preliminary findings when they talk to the media. I dont blame them it must be exciting for them, but take this with a grain of salt. We have many drugs that act in a similar manner by occupying receptors and the like, for many different hormones and proteins people previously believed to be adverse to our everyday functioning. Then you go and use the drug and find out first hand why your body needs those particular hormones at certain levels. Its like cortisol, everybody believes it to be a big bad boogeyman, yet cortisol blockers never came into widespread use because cortisol is a necessity to a variety of positive functions. No hormone or protein in your body is "good" or "bad" they all generally serve a very necessary purpose. Of course that doesnt mean you can't tinker for better effect, but trying to eliminate stuff never works how people want it to. Estrogen is another example, its one of the primary factors in many types of cancer, especially breast cancer for women, and is effectively treated by selective estrogen receptor modulators such as tamoxifen and clomiphene - and they work well, except for the fact they generally make patients feel like shit and can have a host of deleterious effects because estrogen is no longer playing its crucial role (in both men and women)

[QUOTE=Starpluck;41575655]It's called Xanax.[/QUOTE] Ain't the best chill pill if taking it too much can completely remove your ability to be chill without it.

man fuck that molecule

And the awful, awful insomnia.

[QUOTE=U.S.S.R;41575698]Ain't the best chill pill if taking it too much can completely remove your ability to be chill without it.[/QUOTE] It's a chill pill, not a chill cure. You shouldn't be taking benzos longer than a few weeks in the first place.

[QUOTE=Chickens!;41575526]If they blocked the receptors with a drug, wouldn't that make it all the worse once you get off the drug?[/QUOTE] Fair enough point, i'd wager that this drug would be highly addictive too. EDIT: I misread, whoops. But my point still stands the Xanax and other Benzo's are some of the more dangerous drugs around.

[QUOTE=Starpluck;41575729]It's a chill pill, not a chill cure. You shouldn't be taking benzos longer than a few weeks in the first place.[/QUOTE] Well, that's why I'm writing this message right now and arguing about AI in another thread instead of sleeping. And better yet, I was [i]mixing[/i] two benzos, one for long term use, and one for panic attacks. So, a word of advice kids, don't get too chill on the chill pill or you'll freeze.

[QUOTE=.Isak.;41575508]Our bodies respond to stress in such a stupid way. Seriously, shutting yourself in a cave and pretending that the lion outside doesn't exist while bawling your eyes out about the inevitability of your death is one of the most idiotic survival mechanisms ever.[/QUOTE] Good metaphor regarding exams.

[QUOTE=qwerty000;41575574]Ok. Let me rephrase it. Gimme the pill that gets rid of it :v:[/QUOTE] Here's the pill: [url]http://download.cnet.com/Cold-Turkey/3000-2381_4-75851091.html[/url] Block every site that's not related to whatever important thing you're doing. You'll suddenly realize how much damn time you have and are wasting away.

[QUOTE=Swebonny;41575852]Here's the pill: [url]http://download.cnet.com/Cold-Turkey/3000-2381_4-75851091.html[/url] Block every site that's not related to whatever important thing you're doing. You'll suddenly realize how much damn time you have and are wasting away.[/QUOTE] I did this and my reaction wasn't "look at all the time!" it was "wow i'm a fucking lazy bastard what am I doing with my life wow fuck all this shit i'm so lazy i'm never going to get my school stuff done and then i won't go to college and my life will be fucked up i hate myself for being so lazy ugh why am i such a failure" now I just take adderall gg no re

[QUOTE=JaegerMonster;41575696]Wouldnt get too excited just yet. Scientists have a bad habit of being overly enthusiastic with their preliminary findings when they talk to the media. I dont blame them it must be exciting for them, but take this with a grain of salt.[/QUOTE]It's not the scientists who hype it up, it's usually the PR department of whatever organization they work for or an overenthusiastic/unscrupulous journalist. [editline]24th July 2013[/editline] There's an SMBC comic that describes it wonderfully, but i'll be buggered if I can remember what it's called.

[QUOTE=qwerty000;41575574]Ok. Let me rephrase it. Gimme the pill that gets rid of it :v:[/QUOTE] It might turn out to have to be an injection. Think peptides. Or a nasal spray, or an implant (would also help people stay on their meds) [editline]24th July 2013[/editline] Also, inderal is great for stress.

[QUOTE=Moupi;41575445]Nice! Can I get me some of that molecule and weaponize it. My foes will kneel over and weep - the next step in non-lethal warfare.[/QUOTE] [video=youtube;uWh3k-BQrbc]http://www.youtube.com/watch?v=uWh3k-BQrbc[/video] ?

[QUOTE=Sgt Doom;41575958]It's not the scientists who hype it up, it's usually the PR department of whatever organization they work for or an overenthusiastic/unscrupulous journalist. [editline]24th July 2013[/editline] There's an SMBC comic that describes it wonderfully, but i'll be buggered if I can remember what it's called.[/QUOTE] In this case, it was a scientist. Dr Fiona Marshall, chief scientist. It's not necessarily a bad thing, but taken out of context, which it almost always is when information is given to the public, gives the impression that they are saying "yes we can do <x>" rather than "<x> has some exciting possibilities but dont hold your breath"

[QUOTE=Moupi;41575445]Nice! Can I get me some of that molecule and weaponize it. My foes will kneel over and weep - the next step in non-lethal warfare.[/QUOTE] SOP system

Soma one step closer each day

[QUOTE=Starpluck;41575655]It's called Xanax.[/QUOTE] Zoloft I believe is a hell of a lot better.