i've been searching for the water solubility of seroquel for a little while now and nothings coming up. does anyone know off the top of their head? and quite possibly cite a reputable source?
[quote]Quetiapine fumarate is a white to off-white powder. It is
only very slightly soluble in ether, slightly soluble in
water, and soluble in 0.1 N HCl[/quote]
[quote]Quetiapine fumarate is moderately soluble in water[/quote]
[url]http://www.scribd.com/mobile/documents/3553710[/url]
[url]http://www.psychsearch.net/off_label/seroqueld.pdf[/url]
[editline]18th January 2011[/editline]
failing to find any figures, but it seems to be well accepted that it's pH-dependant; moderately soluble in water, more soluble in acidic solutions, and less soluble in basic solutions.
wtf seroquel is not even recreational why are asking?
Because this forum isnt all about recreational drugs. Its any kind.
seroquel is useful if you need to fall asleep.
[QUOTE=tugnbud;27500780]Because this forum isnt all about recreational drugs. Its any kind.[/QUOTE]
seroquel is nothing you should mess around with tho, just ingest them as you're told to.
why not? it's an antipsycotic with a few un/pleasant side effects. (depending on your personal preferences.. i've gotten fucked up on my normal dose of seroquel at least 2 times, but that's out of like tens of thousands of times i've taken it)
the only thing about it that's universally bad is that it greatly dampens the effects of many drugs, and potentates drugs with depressant qualities so much so that it could become dangerous.
If it's dependant on the acidity of the liquid, go buy some lemon juice and just squirt some of that in with some water.
But if you just want it to sleep, go buy some straight antihistamine tablets. It works really well even if you've had stimulants that are running around system.
[QUOTE=HiddenMyst;27512778]If it's dependant on the acidity of the liquid, go buy some lemon juice and just squirt some of that in with some water.
But if you just want it to sleep, go buy some straight antihistamine tablets. It works really well even if you've had stimulants that are running around system.[/QUOTE]
Actually vinegar and baking soda work alot better for regulating acidity/alkaline.
Quetiapine is fucked up. I think I've got at least 100 pills back home, but I can't eat a single one without falling asleep.
Also, it's a drug that's supposed to balance the chemicals in your brain long term. I don't recommend doing it for fun.
[QUOTE=Pirate Ninja;27514297]Actually vinegar and baking soda work alot better for regulating acidity/alkaline.[/QUOTE]
Probably does. I only suggested lemon juice because it's quite drinkable when slightly diluted. Figured this out when I had to eat 60 odd gel caps full of mescaline (I'll get the pics up some point this week hopefully).
[QUOTE=Remi;27518499]Quetiapine is fucked up. I think I've got at least 100 pills back home, but I can't eat a single one without falling asleep.
Also, it's a drug that's supposed to balance the chemicals in your brain long term. I don't recommend doing it for fun.[/QUOTE]
it doesn't balance the chemicals in your brain it blocks dopamine which is a major neurotransmitter.
fyi dopamine regulates the motor system, reward system, cognition, endocrine system and nausea (shamelessly copy pasted from wiki). anti psychotics (like what seroquel is) can really, really, really fuck you up bad if over prescribed (i say this from first hand experience), and even then just cause it's treating something doesn't necessarily mean the dopamine balance in your brain is good or even moderately meh, it could in some aspects make it much worse regardless of an existing condition
[QUOTE=Remi;27518499]Quetiapine is fucked up. I think I've got at least 100 pills back home, but I can't eat a single one without falling asleep.
Also, it's a drug that's supposed to balance the chemicals in your brain long term. I don't recommend doing it for fun.[/QUOTE]
Are you still Opiate free? I'm finally Nicotine free
Seroquel would be a fucking good daterape drug. Not sure why you'd want to dissolve it in water though. What's wrong with using pills?
the higher water solubility the more you absorb if you snort it.
and it wouldn't be a good date rape drug at all.
[QUOTE=NeoSeeker;27528584]the higher water solubility the more you absorb if you snort it.[/QUOTE]
i thought that the bioavailability for snorting depended on the non-polar solvency of the drug. that is, the lipophilicity, not the water solubility.
[editline]19th January 2011[/editline]
not sure though. both seem valid.
[QUOTE=Pome;27529231]i thought that the bioavailability for snorting depended on the non-polar solvency of the drug. that is, the lipophilicity, not the water solubility.
[editline]19th January 2011[/editline]
not sure though. both seem valid.[/QUOTE]
You're correct but NeoSeeker is correct in most instances too. It's rare that you get a hydrophilic substance that is not effective snorted.
Benzos are nearly all useless snorted and you'll find they do not dissolve in water either.
That's not completely true iirc. many if not all of the benzos come in some sort of preparation where you can put it under your tongue and it can be absorbed that way.
I'm more than half sure if something can be absorbed through the mouth it can be absorbed through your nose as well.
[QUOTE=NeoSeeker;27657527]That's not completely true iirc. many if not all of the benzos come in some sort of preparation where you can put it under your tongue and it can be absorbed that way.
I'm more than half sure if something can be absorbed through the mouth it can be absorbed through your nose as well.[/QUOTE]
This is not true I'm afraid. Xanax is not snortable but is most definitely sublingually active.
Then what's the difference between your nose and your mouth in terms of absorption?
and how come shitloads of people on intervention snort benzos and get pretty high from it?
plus i've snorted klonopin before and was pretty high from it afterwards.
[QUOTE=NeoSeeker;27658120]Then what's the difference between your nose and your mouth in terms of absorption?
and how come shitloads of people on intervention snort benzos and get pretty high from it?
plus i've snorted klonopin before and was pretty high from it afterwards.[/QUOTE]
Xanax is not effective snorted. Any effect will be from the drip. The mouth and nose are quite different in terms of absorbtion. Sublingual and insufflation ROA are quite different and not really comparative. You're not far off at all but Pome hit the nail on the head with his explanation. Although your explanation is correct the majority of the time, there's more to it than solubility.
As soon as i snorted it i had a very noticeable high that made me sit down and do nothing but stare at the TV for 4 hours. no drips either.
Honestly I don't care enough about drugs to research the exact mechanisms and shit like that.
that's what i have you guys for <3
[QUOTE=NeoSeeker;27658491]As soon as i snorted it i had a very noticeable high that made me sit down and do nothing but stare at the TV for 4 hours. no drips either.
Honestly I don't care enough about drugs to research the exact mechanisms and shit like that.
that's what i have you guys for <3[/QUOTE]
Fair enough. I'm pretty sure anything you feel from snorting Xanax and most other benzos is placebo and/or the drip (which will always occur btw). I recommend going for a sublingual dosage mechanism if you want a fast release. You are definitely wasting it if you're snorting. This is due to lack of lipophilia with benzos as pome has indicated.
Oral use is much better for you anyway.
i meant to say there weren't any drips until like 5 minutes after i snorted it and by that time i was pretty high
[QUOTE=NeoSeeker;27658838]i meant to say there weren't any drips until like 5 minutes after i snorted it and by that time i was pretty high[/QUOTE]
I've heard many reports of people saying snorting benzos works but you'll be amazed at how powerful the nucleus accumbens part of the brain is at creating an authentic experience. Ex-coke addicts watching videos of people snorting coke demonstrate significant dopamine release when viewing the videos. Placebo and psychosomatic behaviour is most real, even if it's psychological.
it was authentic, i had never done it before and it produced the same effects as swallowing one, which i soon did after the snorted high wore off. plus i'm incredibly depersonalized/etc, i've never experienced a placebo effect in my life.
[QUOTE=NeoSeeker;27659003]it was authentic, i had never done it before and it produced the same effects as swallowing one, which i soon did after the snorted high wore off. plus i'm incredibly depersonalized/etc, i've never experienced a placebo effect in my life.[/QUOTE]
I have tried snorting Xanax before and I definitely experienced some sort of physical response but all the evidence points towards this being placebo. It's impossible to say for certain but the placebo effect being so strong, even as far as appeasing diseases, we cannot be sure that it works.
I prefer to believe in empirical evidence than anecdotal evidence. I agree that a study should be conducted on bioavailablity of benzos.
Sorry, you need to Log In to post a reply to this thread.
