Effects in man of short- and long-term use of cannabis sativa - Polidicks

[Quote]Cannabis sativa is one of man's oldest and most widely used drugs. It has been consumed in various ways as long as medical history has been recorded and is currently used throughout the world by hundreds of millions (2, 3, 81, 101, 211). A fairly consistent picture of its short-term effects is presented in the many publications on Cannabis users. There are, however, strongly contradictory opinions about whether the ultimate effects are harmful, harmless, or beneficial to human functioning (166). Despite these conflicting opinions, from the scientific point of view, the literature is as clear, if not clearer, than for many other botanical substances consumed by man. [B]Most of the older reports suffer from multiple scientific defects such as biased sampling, lack of control groups and use of substances of unknown potency.[/B] However, contrary to popular belief, much is known about the use of Cannabis by man (67).[/Quote]This study was just released in 2011. Whatever you thought you knew from that previous study, forget it. The researchers themselves had this to say about it and others like it: [Quote][B]Studies like these suffer from biased sampling, poor data collection techniques, and a failure to control for such important variables as level of nutrition, socio-economic status, overall standard of living, as well as cultural determinants.[/B][/Quote]If you want to hear legitimate, unbiased information in regards to what is and what isn't in the world of cannabis in regard to its effects and what it does to your body, then I suggest you take a look at [URL="http://www.drugtext.org/Marihuana-and-Health/effects-in-man-of-short-and-long-term-use-of-cannabis-sativa.html"]this.[/URL] [IMG]http://www.drugtext.org/images/stories/books/mh/mh03.jpg[/IMG]

Dude, as awesome as we both think weed is, you need to lay off this "weed is perfect and has no issues" thing, it's tiring and it shows again how unwilling you are to accept any claim that doesn't already fit with your world view. I'll judge this study on it's own merits, as you should judge the last one on it's merits. it had less problems than you imagined.

Weed can kill you

My friend overdosed on THC. Hes a paraplegic now

[quote]The only physical effect firmly linked to long-term cannabis use at present is permanent congestion of the transverse ciliary vessels of the eye and an accompanying yellow discoloration (6, 32, 52, 62). No other chronic physical damage has been satisfactorily demonstrated although there are other suspected or reported effects. It is noteworthy that many of the experimental studies of acute and chronic drug effects discussed earlier used as subjects individuals with at least one year and often longer histories of moderate to heavy marihuana usage. However, none were able to differentiate between these subjects and naive subjects with respect to physical or laboratory findings.[/quote] Awesome. I shall smoke until my eyes are yellow. They're pretty white right now so even though I smoke every day I'm clearly not trying hard enough.

I knew a guy who's friend's family was killed by THC.

[QUOTE=J Paul;28499165]Awesome. I shall smoke until my eyes are yellow. They're pretty white right now so even though I smoke every day I'm clearly not trying hard enough.[/QUOTE] Clearly you're not smoking enough

From the looks of it, this is using thirty, seventy year old data, in which all of the studies cited have had huge flaws, either relating to confirmation bias, spoofed results, stupid research practices or weren't even peer reviewed. Face it bro, weed isn't perfect, and comes with it's own set of troubles, just like every single drug out there.

-snip-

I know a guy who knows a guy who knows a guy who knows a guy's cousin who knows another guy that knows a cop that heard from another guy who knows a guy that knows a guy's sister who knows a guy who said that her brother died from an overdose on marijuana.

Let the boxes consume you

from those studies it is safe to say weed makes you lazy and increases your butthole heat

[QUOTE=ExplodingGuy;28499225]From the looks of it, this is using thirty, seventy year old data, in which all of the studies cited have had huge flaws, either relating to confirmation bias, spoofed results, stupid research practices or weren't even peer reviewed. [/QUOTE] [citation needed]

Looks less harmful then alcohol

So because the researchers of this particular study say that all previous studies are biased, they must all be biased even if they appear not to be? A classic example of the conspiracy theorist's brain. [editline]8th March 2011[/editline] [QUOTE=ShukaidoX;28499318][citation needed][/QUOTE] [release]1. Abel, E. Marijuana and memory. Nature 227 (5263) : 1151-1152, Sept. 12, 1970. 2. Adams, R. Marihuana. Bulletin of the New York Academy of Medicine, 18: 705-730, 1942. 3. Adams, R. Marihuana. Harvey Lectures, Series 37, p. 168-197, 1941-1942. 4. Aldrich, C. K. The effect of a synthetic marihuana-like compound on musical talent as measured by the seashore test. Public Health Reports, 59: 431-433, 1944. 5. Allentuck, S. & Bowman, K. M. The psychiatric aspects of marihuana intoxication. American Journal of Psychiatry, 99: 248-251, 1942. 6. Ames, F. A clinical and metabolic study of acute intoxication with cannabis sativa and its role in the model psychoses. Journal of Mental Sciences, 104 (437) : 972-999, 1958. 7. Asuni, T. Socio-psychiatric problems of cannabis in Nigeria. UN Bulletin on Narcotics, 16 (2 ) : 17-28, 1964. 8. Baker, A. A. & Lucas, E. G. Some hospital admissions associated with cannabis. Lancet, I: 148, January 18, 1969. 9. Baker-Bates, E. T. A case of Cannabis indica intoxication. Lancet, I: 811, 1935. 10. Barbero, A. & Flores, R. Dust disease in hemp workers. Archives of Environmental Health, 14: 533-544 (1967). 11. Bartolucci, G., Fryer, L., Perris, C. & Shagass, C. Marijuana psychosis: a case report, Canadian Psychiatric Association Journal, 14: 77-79, 1969. 12. Beringer, K., et al. Zur klinik des hashischrausches. Der Nervenarzt, 5: 337-350, 1932. 13. Birch, E. C. The use of Indian hemp in the treatment of chronic chloral and chronic opium poisoning. Lancet, I: 624 (March 30, 1889). 14. Boroffka, A. Mental illness and Indian hemp in Lagos. East African Medical Journal, 43: 377-384, 1966. 15. Bose, B. C., Saill, A. Q. & Bhagwat, A. W. Observations on the pharmacological actions of cannabis Indica. Part II. Archives Internationales de Pharmacodynamie et de Therapie, 147 (1-2) : 285-290, 1964. (Biol. Abstr., 45: 95777, 1964). 10. Bouhuys, A., Barbero, A., Lindell, S. E., Roach, S. A., & Schilling, R. S. F. Byssinosis in hemp workers. Archives of Environmental Health, 14: 533- 544, 1967. 17. Bouquet, J. Cannabis. UN Bulletin on Narcotics, 2(4) : 14-30, 1950; 3(1) : 22-45, 1951. 18. Bouquet, J. Marihuana intoxication (letter). Journal of the American Medical Association, 124: 1010-1011, 1944. 19. Brill, N. 0., Crumpton, E., Frank, I. M., Hochman, J. S., Lomax, P., McGlothlin, W. H., & West, L. J. The marijuana problems; UCLA Interdepartmental Conference, Annals of Internal Medicine, 73(3) : 449-465, September 1970. 20. Bromberg, W. Marihuana, a psychiatric study. Journal of the American Medical Association, 113: 4-12, 1939. 21. Bromberg, W. Marihuana intoxication, a clinical study of cannabis sativa intoxication. American Journal of Psychiatry, XCL(2) 303-330 September 1934. 22. Brooks, W. L. A case of recurrent migraine successfully treated with cannabis indica. Indian Medical Record, II: 338, 1896. 23. Brown, J. Cannabis : A valuable remedy in menorrhagia. British Medical Journal, 1:1002, May 26, 1883. 24. Caldwell, D. F., Myers, S. A., & Domino, E. F. Effects of marihuana smoking on sensory thresholds in man. In: Efron, D., ed. Psychotomimetic drugs. New York, Raven Press, 1970, p. 299-321. 25. Caldwell, D. F., Myers, S. A., Domino, E. F. & Merriam, P. E. Auditory and visual threshold effects of marihuana in man. Perceptual and Motor Skills, 29:755-759, 1969. 26. Caldwell, D. F., Myers, S. A., Domino, E. F., & Merriam, P. E. Auditory and visual threshold effects of marihuana in man : Addendum. Perceptual and Motor Skills, 29 :922, 1969. 27. The cannabis problem : a note on the problem and the history of international action, UN Bulletin on Narcotics, 14 (4) :27-31, 1962. 28. Carakushansky, G., New, R. F., & Gardner, L. I. Lysergide and cannabis as possible teratogens in man. Lancet, 11 :150-151, January 18, 1969. 29. Charen, S. & Perelman, L. Personality studies of marihuana addicts. American Journal of Psychiatry, 102:674-682, 1946. 30. Chevers, N. A Manual of Medical Jurisprudence for India. Calcutta, Thacker, Spink & Co., 1870. 31. Chopra, G. S., Man and marijuana, International Journal of the Addictions, 4:215-247, June 1969. 32. Chopra, I. C., & Chopra, R. N. The use of the cannabis drugs in India. UN Bulletin on Narcotics, 9 (1) :4-29, January-March, 1957. 33. Chopm, R. N. Drug addiction in India and its treatment. Indian Medical Gazette, 70 (3 ) :121, 1935. 34. Chopra, R. N. Use of hemp drugs in India. Indian Medical Gazette, 75 (6) : 356-367, 1940. 35. Chopra, R. N., & Chopra, G. S. The present position of hemp-drug addiction in India. Indian Medical Research Memoirs, No. 51 :1-119, 1939. 36. Chopra, R. N., Chopra, G. S., & Chopra, I. C. Cannabis sativa in relation to mental diseases and crime in India. Indian Journal of Medical Research, 30(1) :155-171, 1942. 37. Christiansen, J. & Rafaelsen, 0. J. Cannabis metabolites in urine after oral administration. Psychopharmacologia (Berlin), 14-115-123, 1969. 38. Christozov, C. L'aspect Marocian de l'intoximtion cannabique d'apres des etudes sur des malades mentaux chroniques : lere partie et seme partie. Maroc Medical, 44-630-642; 866-899, 1965. • 39. Clark, L. D., & Nakashima, E. N. Experimental studies of marihuana. American Journal of Psychiatry, 125:379-384, 1968. 40. Clark, L. D., Hughes, R., & Nakashima, E. N. Behavioral effects of marihuana: Experimental studies. Archives of General Psychiatry, 23 :193- 198, September 1970. 41. Conos, B. Trois cas de cannabisme avec psychose consecutive. Bulletin de la Societe de Pathologic exotigue, 18 :788-793, 1925. 42. Crancer, A., Dille, J. M., Delay, J. C., Wallace, J. E., & Haykin, M. D. simulated driving performance. Science, 164 :851-854, May 16, 1969. 43. Curtis, H. C., & Wolfe, J. R. Psychosis following the use of marihuana with report of cases. Journal of the Kansas Medical Society, 40:515-517, 526- 528, 1939. 44. Dagga. South African Medical Journal, 25 (17) :284-286, 1951. 45. Dagirmanjian, R., & Boyd, E. S. Some pharmacological effects of two tetrahydrocannabinols. Journal of Pharmacology and Experimental Therapeutics,1935 :25-33, 1962. 46. Daily, P. Undesirable effects of marijuana. British Medical Journal, 367, August 5, 1967. 47. da Silva, J. B. Chromatographic determination of cannabinol in the blood, urine and saliva of subjects addicted to cannabis sativa. Rev. Fac. Farm. Biogurm. 5 :205-214, 1957. 48. Davis, J. A., & Ramsey, H. H. Anti-epileptic action of marihuana-active substances. Federation Proceedings, 8 :284-285, 1949. 49. Deakin, S. Death from taking Indian hemp. Indian Medical Gazette, p71, 1880. 50. Defer, B., & Diehl, M. L. Les psychoses cannabiques aigues : A propose de 560 observations. (The acute cannabis psychoses : Regarding 560 observations.) Annales Medico Psychologigues (Paris), 2 (2) :260-266, July 1968. 51. Dhunjibhoy, J. E. A brief resume of the types of insanity commonly met with In India with a full description of "Indian hemp insanity" peculiar to the country. Journal of Mental Science, 76:254-264, 1930. 52. Dhunjibhoy, J. E. The role of "Indian hemp" in causation of insanity in India. Far Eastern Association of Tropical Medicine, Transactions of 7th. Session, 1 :400-407, 1928. 53. Dinshaw, V. Complete aphonia after ganja-smoking recovery. Indian Medical Record. 11 :14, 1896. 54. Dobell, H. On some effects of cannabis indica. Medical Times Gazette. 2 :245-246, 1863. 55. Domino, E. F. Human pharmacology of marijuana smoking. (Paper presented, 71st Annual Meeting, American Society for Clinical Pharmacology & Therapeutics, 1970) Journal of Clinical Pharmacology Therapeutics. (in press) 56. Dornbush, R. L., & Freedman, A. M. Marihuana, cognition and perception. (Paper to be presented, American Psychiatric Association, 1971.) 57. Douglas, J. On the use of Indian hemp in Chorea. Edinburgh Medical Journal, 14 :777-784, 1883. 58. Dwarakanath, S. C. Use of opium and cannabis in the traditional systems of medicine in India. UN Bulletin on NarCotics, 17 (1) :15-19, 1965. 59. Edes, R. T. Cannabis indica. Boston Med. Burg. J., 129-273, September 14, 1893. 60. Effects of alcohol and cannabis during labor. Journal of the American Medical Association, 94:1165, April 12, 1930. 61. Efron, Daniel H. Cannabis (marihuana) research. In: Committee on Problems of Drug Dependence. Bulletin, problems of drug dependence. (Minutes of the 29th Meeting, February 13-16, 1967, Lexington, Ky.) Washington, D.C., National Academy of Sciences, National Research Council, Division of Medical Sciences, 1967, p. 4829-4831. 62. Ewens, G. F. W. Insanity following the use of Indian hemp. Indian Medical Gazette, 39:401-413, 1904. 63. Farlow, J. W. On the use of belladonna and cannabis indica by the rectum In gynecological practice. Boston Med. Burg. J., 120:507-509, May 23, 1889. 64. Favazza, A., & Domino, E. F. Recurrent LSD experience (flashbacks) triggered by marihuana. University of Michigan Medical Center Journal, 35 :214-216, 1969. 65. Fere, C. Note sur l'influence du haschisch sur le travail, Comptes rendus hebdomadaires des seances de la Societe de Biologie, (11eme serie), 3 :696- 700, 1901. 66. Ferenczy, L., Gracza, L., & Jakobey, I. An antibacterial preparatum from hemp (cannabis sativa, L.). Naturwis senschaf ten, 45:188, 1958. 67. Fink, M. The biology of cannabis ; The state of our knowledge, 1970. (Paper presented at American Public Health Symposium on Cannabis, San Francisco, May 13, 1970.) 68. Fischlowitz, G. G. Poisoning by cannabis indica. Medical Record, 50 :280- 281, August 22, 1896. 69. Foltz, R. L., Kinzer, G. W., Mitchell, R. I., & Truitt, E. B., Jr. The fate of cannabinoid components of marihuana during smoking. J. Analytical Chemistry, (in press). 70. Fox, R. H. Headaches, a study of some common forms, with especial reference to arterial tension and to treatment. Lancet, Vol. III: 307 :309, August 7, 1897. 71. Francois, G. R., Barrat, E., Russel, G., Barker, T., & White, R. B. The marihuana dilemma—a clinical and experimental approach. (Paper presented, Reconvened Annual Meeting, American Psychiatric Association, Honolulu, Hawaii, May 19, 1970) 72. Frank, I. M., Hepler, R. S., Stier, S., & Rickles, Wm. Marijuana tobacco and functions affecting driving. (Paper to be presented, American Psychiatric Association, Annual Meeting, Washington, D.C., May 1971). 73. Fraser, J. Treatment of tetanus with cannabis indica. Medical Times Gazette. Vol. I, February 7, 1862. 74. Fraser, J. D. Withdrawal symptoms in cannabis indica addicts. Lancet, 2:747, 1949. 75. Freedman, H. L., & Rockmore, M. J. Marihuana, a factor in personality evaluation and Army maladjustment. Journal of Clinical Psychopathology, 7:765-782 (Part I) ; 8:221-236 (Part II) 1946. 76. Gaoni, Y., & Mechoulam, R. Isolation, structure, and partial synthesis of an active constituent of hashish. Journal of the American Chemical Society, 86:1646, 1964. 77. Garattini, S. Effects of a cannabis extract on gross behavior. In: Wolstenholme, G. E. W., & Knight, J., eds. Hashish: Its chemistry and pharmacology. Boston, Little, Brown & Co., 1965. (Ciba Foundation Study Group 21, October 21, 1964) 78. Gary, N. E., & Keylon, V. Intravenous administration of marihuana. Journal of the American Medical Association, 211 (3) :501, January 19, 1970. 79. Gaskill, H. S. Marihuana, an intoxicant. American Journal of Psychiatry, 102:202-204, 1945. 80. Goodman, L. S. & Gilman, A. The pharmacological basis of therapeutics, New York, Macmillan Co., 1955. 81. Grinspoon, K. Marihuana. Scientific American, 221:17-25, December 1969. 82. Grossman, W. Adverse reactions associated with cannabis products in India. Annals of Internal Medicine, 70(3) :529-533, March 1969. 83. Halpern, M., et al. Necrotizing angiitis asof4ated with drug abuse. Abstracts of Association of University .Radiologists, 18th Annual Meeting, p. 16. 84. Hamaker, S. T. A. case of overdose of cannabis indica. Ther. Gaz., 7 :808, December 15, 1891. 85. Hecht, F. Beals, R. K., Lees, M. H., Jolly, H., & Roberts, P. Lysergic-aciddiethylamide and cannabis as possible teratogens in man. Lancet, 11 :1087, November 16, 1968. 86. Heiman, E. M. Marihuana precipitated psychosis in patient evacuated to CONUS. USARU Medical Bulletin, 40(9) :75, 1968. 87. Henderson, A. H., & Pugsley, D. J. Collapse after intravenous injection of hashish British Medical Journal, 3 :229-230, July 27, 1968. 88. Hemenway, S. Poisoning by strychnine, successfully treated by cannabis. Pacific Medicine and Surgery Journal, 10 :113-114, 1867. 89. Hepler, R. S., Frank I. M., & Ungerleider, J. T. The effects of marijuana smoking on pupillary size, (American Journal of Ophthalmology, 1971, to be published). 90. Heyndrickx, A., Scheiris, C., & Schepens, P. Toxicological study of a fatal intoxication in man due to cannabis smoking. Journal de- Pharmacie de Belgique, 24:371-376, July-August. (Chem. Abstract 72:4117-1970.) 91. Himmelsbach, C. K. Treatment of the morphine abstinence syndrome with a synthetic cannabis-like compound. Southern Medical Journal, 37 :26- 29, 1944. 92. Hollister, L. E. Hunger and appetite after single doses of marihuana, ethanol and dextroamphetamine. Clinical Pharmacology and Therapeutics, (to be published). 93. Hollister, L. E. Steroids and moods : Correlations in schizophrenics and subjects treated with lysergic acid diethylamide (LSD), mescaline, tetrahydrocannabinol, and synhexyl, Journal of Clinical Pharmacology, 9 :24- 29, January-February 1969. 94. Hollister, L. E., & Gillespie, H. K. Marihuana, ethanol and dextroamphetamine ; Mood and Mental Function Alterations, Archives of General Psychiatry, 23:199-203, September 1970. 95. Hollister, L. E., & Moore, F. Urinary catecholamine excretion following lysergic acid diethylamide in man. Psychopharmacologia (Berlin). 11:270, 1967. 96. Hollister, L. E., & Moore, F. Urinary catecholamine excretion following mescaline in man, Biochemistry Pharmacology, 17 :2015, 1968. 97. Hollister, L. E. Moore, F., Kanter, S., & Noble, E. Delta-l-tetrahydrocannabinol, synhexyl and marihuana extract administered orally in man : Catecholamine excretion, plasma cortisol levels and platelet serotonin content. Psychopharmacologia (Berlin) 17, 354-360, 1970. 98. Hollister, L. E., Richards, R. K., & Gillespie, H. K. Comparison of tetrahydrocannabinol and synhexyl in man. Clinical Pharmacology and Therapeutics, 9:783-791, November-December 1968. 99. Hollister, L. E., Sherwood, S. L., & Cavasino, A. Marihuana and the human electroencephalogram, Pharmacological Research Communications, 1971 (to be published). 100. Hughes, J. E., Steahly, L. P., & Bier, M. M. Marihuana and the diabetic coma. Journal of the American Medical Association, 214 (6) :1113-1114, November 9, 1970. 101. Indian Hemp Drugs Commission Report, 1893-1894, Marihuana, Introduction by J. Kaplan, Silver Spring, Maryland, Thos. Jefferson Publishing Co.. 1969. 102. Interim Report of the Commission of Inquiry into the Non-Medical Use of Drugs, Chairman G. LeDain, Queen's Printer for Canada, Ottawa, Canada, 1970. 103. Ireland, T. Insanity from the abuse of Indian hemp. Alienist and Neurologist, 14:622-630, 1893. 104. Isbell, H., & Jasinski, D. R. A comparison of LSD-25 with (-) -Delta-9- trans-tetrahydrocannabinol (THC ) and attempted cross tolerance between LSD and THC. Psychopharmacologia, 14:115-123, 1969. 105. Isbell, H., Gorodetzsky, C. W., Jasinski, D. R., Claussen, U., Von Spulek, F. & Korte, F. Effects of (-)-Delta-9-trans-tetrahydrocannabinol in man, Psychopharmacologia (Berlin), 11:184-188, 1967. 106. Isbell, H., Jasinski, D. R. Gorodetsky, C. W., Korte, F., Claussen, U., Haage, M., Sieper, II., & Von Spulak, F. Studies on tetrahydrocannabinol. In: Bulletin, Problems of Drug Dependence. (Minutes of the 29th meeting, February 13-16, 1967, Lexington, Ky.) Washington, D.C. Committee on Problems of Drug Dependence, National Academy of Sciences, Division Medical Science, 1967, p. 4832-4846. 107. Jaffe, J. H. Clinical characteristics : Cannabis (marihuana) addiction. In: Goodman, L. S., & Gilman, R., eds. The Pharmacological basis of therapeutics. New York, Macmillan Co., 1965. 108. Jones, R., & Stone, G. Psychological studies of marijuana and alcohol in man. Psychopharmacologia (Berlin) 18:108-117, 1970. 109. Kabelik, J., et al. Cannabis as a medicament. UN Bulletin on Narcotics, 12 (3) :5-23. 1960. 110. Keeler, M. H. Adverse reaction to marihuana. American Journal of Psychiatry, 124:674-677, 1967. 111. Keeler, M. H. Marihuana induced hallucinations. Diseases of the Nervous System, 29:314-315, May, 1968. 112. Keeler, M. H., & Reitler, C. B. Grand mal convulsions subsequent to marihuana use : Case report. Diseases of the Nervous System, 28:474-475, 1967. 113. Keeler, M. H., Reifier, C. B., & Liptzin, M. B. Spontaneous recurrence of marihuana effect. American Journal of Psychiatry, 125 :384,386, 1968. 114. Kelley, W. M. Cannabis Indica. British Medical Journal, 1 :1281, June 30, 1883. 115. Keup, W. Psychotic symptoms due to cannabis abuse. Diseases of the Nervous System, 31 (2) :119-126, February 1970. 116. Kew, M. C., Bersohn, L., & Slew, S. Possible hepatotoxicity of cannabis. Lancet, 1 :578-579, March 15, 1969. 117. King, A. B., & Cowen, D. L. Effect of intravenous injection of marihuana. Journal of the American Medical Association, 210(4) :724-725. 118. Lambo, T. A. Medical and social problems of drug addiction in West Africa, with special emphasis on psychiatric aspects. UN Bulletin on Narcotics, 17 (1) :3-13, 1965. 119. Lemberger, L., Silberstein, S. D., Axelrod, J., & Kopin, I. J. Marihuana : Studies on the disposition and metabolism of delta-9-tetrahydrocanna• binol in man. Science, 170:1320-1322, December 18, 1970. 120. Lerner, M., & Zeffert, J. T. Determination of tetrahydrocannabinol isomers in marijuana and hashish. UN Bulletin on Narcotics, XX (2) :53-54, April-June, 1968. 121. Lindemann, E. The neurophysioloolcal effects of inxtoxicating drugs. American Journal of Psychiatry, 90'; 1007-1037, 1933-1934. 122. Loewe, S. Studies on the pharmacology and acute toxicity of compounds with marihuana activity. Journal of Pharmacology and Experimental Therapeutics, 88: 154-161, October 1946. 123. Loewe, S. & Goodman, L. S. Anti-convulsant action of marihuana-active substances. Federation Proceedings, 6 (1 ) : 352, 1947. 124. Ludlow, F. The hasheesh eater : Being passages from the life of a pythagorean. New York, Harper and Brotbers, 1857. 125. MacKenzie, S. Indian hemp in persistent headache. Journal of American Medical Association, Vol. 9: 731-732, December 3, 1887. 126. Mann, P. E. G., Finley, T. N. & Ladman, A. j. Marijuana smoking : A study of its effects on alveolar lining material and pulmonary macrophages recovered by bronchopulmonary lavage. Journal of Clinical Investigations, June 1970, p. 60a-61a. 127. Manno, J. E. Clinical investigations with marihuana and alcohol. (Submitted to the Faculty of the Graduate School in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Pharmacology & Toxicology, Indiana University, 1970). 128. Manno, J., Kiplinger, G. R., Bennett, I. F., Bayne, S., Forney, R. B. Comparative effects of smoking marihuana on motor and mental performance In humans. Clinical Pharmacology and Therapeutics, 11 (6) : 808-815, November-December 1970. 129. Manno, J. E., Kiplinger, G. R., Bennett, I., Forney, R. B. Human motor and mental performance under the influence of marihuana and/or alcohol. (Paper presented at the Ninth Annual Meeting of the Society of Toxicology, Atlanta, Georgia, March 1547, 1970) (abstract) Toxicology and Applied Microbiology, 16 : 85,1970. 180. Marcovitz, E. & Myers, H. J. The marihuana addict in the Army. War Medicine, 6: 382-391,1944. 181. Marten, G. W. Case report : Adverse reaction to the use of marihuana. Journal of the Tennessee Medical Association, 62 (7) : 627-630, July 1969. 182. Mattison, J. Cannabis Indica as an anodyne and hypnotic. St. Louis Medical and Surgical Journal, 61 : 265-271, November 1891. 133. Mayer-Gross, W., et al. Clinical Psychiatry, London ; Cassell, 1960. 134. Mayor's Committee on Marihuana. The Marihuana Problem in the City of New York: Sociological, medical, psychological and pharmacological studies. Lancaster, Pennsylvania, Cattail Press, 1944. 135. McGlothlin, W. H., & West, L. J. The marihuana problem : An overview. Ameriacn Journal of Psychiatry, 125: 126-134, September 1968. 136. McGlothlin, W. H., Case, H., & Moskowitz, H. E. Effects of marihuana on driving and attention. (Personal communication). 187. McGlothlin, Wm., Aparkes, R. S., & Rowan, P. K. Marihuana use among adults. Psychiatry (in press). 138. Meehoulam, R. Marihuana chemistry. Science, 168 (3936) : 1159-1166, June 5,1970. 189. Mechoulam, R., & Gaoni, Y. A total synthesis of d1-p-1-Tetrahydrocannabinol, the active constituent of hashish. Journal of the American Chemical Society, 87 : 3273-3275, 1965. (Chemical Abstracts 63: 9849a, 1965) 140. Mechoulam, R., Shan', A., Edery, H & Grunfeld, Y. The chemical basis of hashish activity. Science, 169 (3945) :611-612, August 7,1970. 141. Melges, F. T., Tinklenberg, J. R., Hollister, L. E. & Gillespie, H. K. Marihuana and temporal disintegration. Science, 168(3935) :1118-1120, May 29,1970. 142. Melges, F. T., Tinklenberg, J. R., Hollister, L. E., & Gillespie, H. K. Temporal disintegration and depersonalization during marijuana intoxication. Archives of General Psychiatry, 23 :204-210,1970. 143, Merrill, F. T. Marihuana, the new dangerous drug. Washington, Opium Research Committee, Foreign Policy Association, Inc., March 1938. 144. Meyer, R. E., Pillard, R. C., Mirin, S. M., Shapiro, L. S. & Fisher, S. Administration of marihuana to heavy and casual users. (Paper to be presented at American Psychiatric Association Meeting, Washington, D.C., May 1971). 145. Meyers, S. A., & Caldwell, D. F. Effects of marihuana on auditory and visual sensation. Research Bulletin, Spring 1929,20-22. 146. Meyers, S. A., & Caldwell, D. F. The effects of marihuana on auditory and visual sensation, a preliminary report. The New Physician, 18:212-215, March 1969. 147. Mikuriya, T. H. Cannabis substitution, an adjunctive therapeutic tool in the treatment of alcoholism. Medical Times, 98(4) :187-191, April 1970. 148. Kikuriya, T. H. Historical aspects of cannabis sativa in Western medicine. The New Physician,18 :902-908, December 1969. 149. Mikuriya, T. H. Marihuana In medicine, past, present and future. California Medicine, 110 :34-40,1969. 150. Miller, J. Case of traumatic tetanus, following injury of the finger, treated by amputation of the injured part, the application of cold to the spine and the internal use of cannabis indica. Monthly Journal of Medical Sicence, 5 :22-30. 151. Minter, L. J. Indian hemp poisoning. British Medical Journal, 11 :1773-1774, December 19, 1896. 152. Mirin, S. M., Shapiro, L. M., Meyer, R. E., Pillar, R. C., Fisher, S. Casual vs. heavy use of marihuana, a redefinition of the marihuana problem. (Paper presented at American Psychiatric Association Meeting May 1970, Washington, D.C.). (In press American. Journal of Psychiatry.) 153. Miras, C. J. Some aspects of cannabis action : In: Hashish : Its Chemistry and Pharmacology, Wolstenholme, G. E. W., and Knight, J., eds., Ciba Foundation Group No. 21, London, J. & A. Churchill, 1965. 154. Mohan, H., & Sood, G. C. Conjugate deviation of the eyes after cannabis indica intoxication. British Journal of Ophthalmology, 48 :160-161, 1964. 155. Murphy, H. B. M. The cannabis habit : A review of recent psychiatric literature. U.N. Bulletin on Narcotics, 15(1) :15-23, 1963. 156. Neu, R. L., Powers, H. 0., King, S. & Gardner, L. I. Cannabis and chromosomes, (Letter), Lancet, :675, March 29, 1969. 157. Oliver, J. On the action of cannabis indica, British Medical Journal, I :905- 906, May 12, 1883. 158. O'Shaughnessy, W. B. Case of tetanus, cured by a preparation of hemp. Trans. Med. Psy. Soc. Cal., 8:462-469, 1842. 159. Palmer, E. L., Fieldbook of natural history. McGraw Hill Book Company, Inc., New York, 1949. 160. Parsons : Treatment of tetanus with cannabis indica. Medical Times Gazette, Vol. I, June 20, 1862. 161. Parker, C. S., & Wrigley, F. Synthetic cannabis preparations in psychiatry. 1. Synhexyl. Journal of Mental Science, 96-276-279, 1950. 162. Parreiras, D. Cannabismo on maconhismo. Estudos brasileiros. Impresna Medica, 1949, 430:34-64. 163. Peebles, A. S. M., & Mann, H. W. Ganja as a cause of insanity and crime In Bengal. Indian Medical Gazette, 49:395-396, 1914. 164. Perna, D. Psychotogenic effect of marihuana. Journal of the American Medical Association, 209 (7) :1085-1086, 1969. 165. Persyko, I. Marihuana psychosis. Journal of the American Medical Association, 212 (9 ) :1527, June 1, 1970. 166. Pillard, R. C. Marihuana. New England Journal of Medicine, 283 (6) :294- 303, August 6, 1970. 167. Pivik, T., Zarcone, V., Hollister, L. E., & Dement, W. The effects of hallucinogenic agents on sleep. Psychophysiology, 6 (2) :261, September 1969. 168. Pond, D. A. Psychological effects in depressive patients of the marihuana homologue "synhexyl." Journal of Neurology, Neurosurgery and Psychiatry, 11 :271-279, 1948. 169. Porot, A. Le cannabisme. Annales Medico-Psychologigues, 1 (1) :1-24 January 1942. 170. President's Advisory Commission on Narcotic and Drug Abuse, Final Report, U.S. Government Printing Office, Washington, D.C., November 1963. 171. President's Commission on Law Enforcement and Administration of Justice, Task Force Report: Narcotics and Drug Abuse. Annotations and Consultants' Papers. TI. S. Government Printing Office, Washington, D.C. 1967. 172. Pretoria Mental Hospital, Report of an Investigation Conducted by the Medical Staff. Mental symptoms associated with the smoking of dagga. South African Medical Journal, 12 :85-88, 1938. 173. Radosevic, A., Kupinic, M., & Grlic, L. Antibiotic activity of various types of cannabis resin. Nature, 195 :1007-1009. 174. Rennie, S. J. On the therapeutic value of tincture cannabis indica in the treatment of dysentery : More particularly in its sub-acute and chronic forms. Indian Medical Gazette 21 :353-354, 1886. 175. Report by the Advisory Committee on Drug Dependence, Cannabis (Wootton Report), London, Her Majesty's Stationery Office, 1968. 176. Reynolds, J. R. Therapeutic uses and toxic effects of cannabis indica. Lan, cet, 1 :637-638, March 22, 1800. 177. Rickles, W. H., Kales, A., & Hanley, J. Psychophysiology of marijuana. (Paper presented, Langley Porter Neurophychiatric Institute, San Francisco, May 27, 1970.) 178. Rickles, W. H., Kales, A., & Hanley, J. Effects of marijuana on evoked heart rate and skin conductance responses. (Paper presented at Society for Psychophysiological Research Meeting, New Orleans, Louisiana, November 22, 1970.) 179. Ritchie, J. M. Ch 11, The aliphatic alcohols, Goodman, L. S., & Gilman, A., eds. In: The Pharmacological basis of therapeutics, pp. 143-153, 3rd. Ed. Macmillan Company, New York 1965. 180. Rodin, E., & Domino, E. F. Effects of acute marijuana smoking in the electroencephalograms. Electroencephalography and Clinical Neurophysiology, 29:321, 1970. 181. Rodin, E., Domino, E. F., & Porzak, J. P. The marijuana-induced "social high"—Neeurological and Electroencephalographic Concomitants, Journal of the American Medical Association, 213:1300-1302, October 1970. 182. Roland, J. L., & Teste, M. Le cannabisme au Maroc, Maroc-Medical, No. 387 :694-703, June 1958. This same article appears under the name of Benabud, A., Psycho-pathological aspects of the cannabis situation in Morocco : statistical data for 1956. UN Bulletin on Narcotics, 9 (4) :1-16, 1957. 183. Rolls, E. J., & Stafford-Clark, D. Depersonalization treated by cannabis indicia and psychotherapy, Guy's Hospital Reports, 103 :330-336, 1954. 184. Rubin, C. E. University of Washington, Seattle, Stimulation of smooth endoplasmic reticulum in the human intestinal absorptive cell by marijuana (personal communication, October 1970). 185. Sasman, Marty. Cannabis indicia in pharmaceuticals. Journal of the New Jersey Medical Society, 35:51-52, January 1938. 186. Scher, J. M. The marihuana habit. Journal of the American Medical Association, 214(6) :1120, November 9, 1970. 187. Schick, J. F., Smith, D. E., & Meyers, F. H. The use of marijuana in the Haight-Ashbury subculture. Journal of Psycchedelic Drugs, 2 (1) :49-66, 1968. 188. Sigg, B. W. Le cannabisme chronique, fruit du sons-development at du capitalisme : Etude socio-economique et psycho-pathologique. Alger, 1963. 189. Slier, J. F., Sheep, W. L., Bates, L. B., Clark, G. F., Cook, G. W., & Smith, W. A. Marijuana smoking in Panama. The Military Surgeon, 73(5) :269- 380, 1933. 190. Silver, A. On the value of Indian hemp in menorrhagia and dysmenorrhea. Medical Times Gazette, 2:59-61. 191. Sim, V. Presented in Proceedings of a Workshop on Psychotoinimetic Drugs in Irvine, California, January 25-26, 1969, Psychotomimetic Drugs, ed. D. Efron, Raven Press, New York 1970. 192. Smith, D. E. Acute and chronic toxicity of marijuana. Journal of Psychedelic Drugs, 2 :37-41, 1968. 193. Smith, D. E., Mehl, C. The analysis of marijuana toxicity. In: Smith, D., ed., The New Social Drug, Englewood Cliffs, New Jersey, Prentice-Hall, Inc., pp. 63-77, 1970. 194. Sonnenreich, C., and Goes, J. F. Marijuana and mental disturbances. Neurobiologia, 25:69-91, 1962. 195. Soueif, M. I. Hashiah consumption in Egypt with special reference to psychosocial aspects. UN Bulletin on Narcotics, 19(2) :1-12, 1967. 196. Snyder, S. H. What have we forgotten about pot. New York Times Magazine, p. 26, December 13, 1970. 197. Sterne, J., & Ducastaing, C. Les arterites du cannabis indica. Archives des Mal. Coeur, 53:143-147, 1960. 198. Stockings, G. T. A new euphoriant for depressive mental states. British Medical Journal, 918-922, 1947. 199. Study of the effects of tetrahydrocannibinol in cancer patients. (Personal communication. Author's name withheld at his request.) 200. Suckling, C. W. On the therapeutic value of Indian hemp. British Medical Journal, 11 :12, July 4, 1891. 201. Talbott, J. A., & Teague, J. W. Marihuana psychosis : acute toxic psychosis associated with the use of cannabis derivatives. Journal of the American Medical Association, 210(2) :299-302, October 13, 1969. 202. Tart, C. T. Marihuana intoxication, common experiences. Nature, 226 (5247) :701-704, May 23, 1970. 203. Thompson, L. J., & Proctor, R. C. The use of pyrahexyl in the treatment of alcoholic and drug withdrawal conditions. North, Carolina Medical Journal, 14:520-523, 1953. 204. Tinklenberg, J. R., Melges, F. T., Hollister, L. E., & Gillespie, H. K. Marihuana and immediate memory. Nature : 226 (5251) :1171-1172, June 20, 1970. 205. Tiriad, N. Toxic effects of cannabis indica. Lancet, 1:723, March 29, 1890. 206. Trease, G. E. A textbook of pharmacognosy. Baltimore, Maryland, William Wood & Co., 1935. 207. Tylden, E., & Wild, D. A case for cannabis? British Medical Journal, 3 :556, 1967. 208. Ungerleider, J. T., Fischer, D. D., Goldsmith, R. S., Fuller, M., & Porgy, E. A statistical survey of adverse reactions to LSD in Los Angeles County. American Journal of Psychiatry, 125 (3) :325-357, 1968. 209. Ungerleider, J. T. (Letter to the Editor), American Journal of Psychiatry, 125 :1448, 1969. 210. Walton, R. P. Marihuana, America's new drug problem. Philadelphia, J. B. Lippincott Co., 1938. 212. Warnock, J. Insanity from hasheesh. Journal of Mental Sciences, 49 :96- 110, 1903. 213. Waskow, I. E., Olsson, J. E., Salzman, C., & Katz, M. M. Psychological effects of tetrahydrocannabinol. Archives of General Psychiatry, 22 (2) : 97-107, 1970. 214. Watt, J. M. Dagga in South Africa. UN Bulletin on Narcotics, 13 (3) :9- 14, 1961. 215. Watt, J. M., & Breyer-Brandwijk, M. B. The forensic and sociological aspects of the dagga problem in South Africa. South African Medical Journal, 10:573-579, 1936. 216. Weil, A. T. Adverse reactions to marijuana. Classification and suggested treatment. New England Journal of Medicine, 282 (18) :997-1000, 1970. 217. Weil, A. T., & Zinberg, N. E. Acute effects of marihuana on speech. Nature, 222: 434-437, May 3, 1969. 218. Weil, A. T., Zinberg, N. E., & Nelsen, J. M. Clinical and psychological effects of marihuana in man. Science, 162 :1234-1242, December, 13, 1968. 219. West, L. J. On the marihuana problem. In: Efron, D., ed., Psychotomimetic Drugs, New York, Raven Press, 1970. 220. White House Conference on Narcotic and Drug Abuse, U.S. Government Printing Office, Washington, 1963. 221. White, R. B., Goolishian, H., & Barrett, E. S. Dilemmas encountered by the marihuana researcher. (Paper presented, 46th Annual Conference of the Central Neuropsychiatric Association, Galveston, Texas, October 16, 1970.) 222. Wikler, A., & Lloyd, B. J. Effect of smoking marihuana cigarettes on cortical electrical activity. Federation Proceedings, 4 :141-142, March 1945. 223. Williams, E. G., Himmelsbach, C. K., Wikier, A., Ruble, D. C., & Lloyd, B. N. Studies on marihuana and pyrahexl compound. Public Health Reports, 61 (29) :1059-1083, July 19, 1946. 224. Winick, C. Use of drugs by jazz musicians. gocial Problems, 7:240-253, 1960. 225. Wurmser, L., Levin, L., & Lewis, A. Chronic paranoid symptoms and thought disorders in users of marihuana and LSD as observed in psychotherapy. Proceedings, Committee on Problems of Drug Dependence, T. H. Mikuriya, National Academy of Science, National Research Council, Washington, D.C. 1969. Bulletin, Problems on Drug Dependence. 226. Youngken, H. W. Textbook of Pharmacognosy, 5th Ed. Philadelphia, Blakiston Co., 1946. 227. Personal Communication of Experimental unpublished data-names withheld by request of the investigators.[/release] [editline]8th March 2011[/editline] Haha what the fuck [quote]200. ...July 4, 1891.[/quote]

[QUOTE=RBM11;28499351]:downswords:[/QUOTE] Classic example of an idiots brain. Doesn't even read the context and assumes he knows everything about the study. Seriously now you're just grasping for straws.

[QUOTE=ShukaidoX;28499394]grasping for straws.[/QUOTE] i legit laughed my ass off. sooo hypocritical

[QUOTE=ShukaidoX;28499394]Classic example of an idiots brain. Doesn't even read the context and assumes he knows everything about the study. Seriously now you're just grasping for straws.[/QUOTE] Hey at least I read what the references of the study were :smug: [editline]8th March 2011[/editline] This must be the latest news in any ITN thread ever

[QUOTE=ShukaidoX;28499394]Classic example of an idiots brain. Doesn't even read the context and assumes he knows everything about the study. Seriously now you're just grasping for straws.[/QUOTE] Did you just miss the point? All your studies are beyond old, and the 2011 study is based on those studies. Holy shit, you're making me argue against weed. Your head is just as far up your ass as strider*'s is.

Trying to convince anyone outside of DD to say weed isn't bad is gonna do about as much as telling christians not to believe in jesus anymore.

[QUOTE=RBM11;28499351]<obviously works for an alcoholic beverage company>[/QUOTE] Marijuana is a Schedule I drug. It has "The drug or other substance has no currently accepted medical use in treatment in the United States." Why be hating on weed? Its a safer alternative to the other shit they allow us to have. Like cigarettes and alcohol. Its starting to just look like a "money game". Private companies like Anheuser Busch, and Miller don't want weed to take over its market. Alcohol is a HUGE money maker. Drunk drivers take lives. Stoners can't even go the speed limit.

Clearly if you critics aren't going to bother reading it and criticizing it for its merits rather than a few lines in the references, a decency I gave you, then why should I bother arguing with you? [editline]9th March 2011[/editline] [QUOTE=Richard Simmons;28499541] Why be hating on weed? Its a safer alternative to the other shit they allow us to have. Like cigarettes and alcohol. Its starting to just look like a "money game". Private companies like Anheuser Busch, and Miller don't want weed to take over its market. Alcohol is a HUGE money maker. [/QUOTE] The group for a Drug Free America, which pushes to keep cannabis illegal, is financed by alcohol and tobacco corporations. Thought it was relevant to your point.

[QUOTE=CjienX;28499514]Trying to convince anyone outside of DD to say weed isn't bad is gonna do about as much as telling christians not to believe in jesus anymore.[/QUOTE] Actually, I have retracted most of what I said about weed because of what I've learned from ITN. However, I still wouldn't smoke it and it still does permanent damage the brain where as alcohol does not.(Although alcohol's effect last long enough that if you drink enough it basically is)

Why do people care so much about the effects of weed? If you actually appreciated it, you wouldn't give a fuck, you'd accept it for what it is, not try and glamorize it as some miracle plant that can cure all ailments. Any smoke you inhale can cause damage to your lungs, any mind-altering substance has a chance to negatively-alter your mind, weed is not exempt from these qualities. If you use it responsibly you won't have any problem with it. End of fucking discussion.

[QUOTE=Swilly;28499623]and it still does permanent damage the brain [/QUOTE] [citation needed]

[QUOTE=ShukaidoX;28499555] The group for a Drug Free America, which pushes to keep cannabis illegal, is financed by alcohol and tobacco corporations. Thought it was relevant to your point.[/QUOTE] A program to keep children off drugs, is funded by a companies that produce goods. That are prohibited for underage sale. Wow, they know how to target their groups effectively.

[QUOTE=Micr0;28499630]Why do people care so much about the effects of weed? [/QUOTE] Because we're still living in prohibition. Prohibition of cannabis. People have a right to put whatever they want into their bodies and we're fighting to this day to be able to. This article is merely another to help convince more people to realize that pot isn't as bad as the establishment says it is. It helps people. A lot. Very sick people. So when I see a ignorant, indoctrinated fuckwit who eats up all that non-sensical bullshit about pot causing psychosis the government puts on Above the Influence it makes me want to show people the truth. This discussion is far from over.

[QUOTE=ShukaidoX;28499770]Because we're still living in prohibition. Prohibition of cannabis. People have a right to put whatever they want into their bodies and we're fighting to this day to be able to. This article is merely another to help convince more people to realize that pot isn't as bad as the establishment says it is. It helps people. A lot. Very sick people. So when I see a ignorant, indoctrinated fuckwit who eats up all that non-sensical bullshit about pot causing psychosis the government puts on Above the Influence it makes me want to show people the truth. This discussion is far from over.[/QUOTE] Don't get me wrong, I support the legalization of marijuana, but it is not completely harmless. I hate it when people believe that reefer madness bullshit too, but I also hate it when people go around saying that cannabis is completely harmless even though numerous studies have shown that it can cause damage (however minimal) to the human body through excessive use.

[QUOTE=ShukaidoX;28499770]Because we're still living in prohibition. Prohibition of cannabis. People have a right to put whatever they want into their bodies and we're fighting to this day to be able to. This article is merely another to help convince more people to realize that pot isn't as bad as the establishment says it is. It helps people. A lot. Very sick people. So when I see a ignorant, indoctrinated fuckwit who eats up all that non-sensical bullshit about pot causing psychosis the government puts on Above the Influence it makes me want to show people the truth. This discussion is far from over.[/QUOTE] Everything here ^

[QUOTE=ShukaidoX;28499555]Clearly if you critics aren't going to bother reading it and criticizing it for its merits rather than a few lines in the references, a decency I gave you, then why should I bother arguing with you?[/QUOTE] Because, all that this supposed "study" is just a bunch of misconstrued references put together. While half of them aren't available online, the rest completely contradict the point of this article. Case in point: [quote]One study has been published regarding the biological fate of Delta-9-THC in man. Lemberger et al. (119) injected a tracer dose (0.6 mg) of radioactivity labeled Delta-9-THC intravenously into three marihuana naive subjects and followed its course in blood, urine and feces. They found that Delta-9-THC is completely metabolized in man. The metabolites appear in the blood within ten minutes, 30% are excreted in the urine and 50% in the feces over a period of eight days. Most are excreted in the first few days. Delta-9-THC in the plasma declines rapidly during the first hour after injection and more slowly thereafter. The initial rapid decline, occurring in the first few hours, probably represents metabolism and a redistribution of Delta9-THC from the blood to the tissues (including brain). This is followed by a slow declining phase over the next three days which presumably represents retention and slow release from tissue stores. Negligible amounts of Delta-9-THC are excreted in the urine and feces. In the present study, the 11-hydroxy-Delta-9-THO metabolite appears to be only a minor metabolite of the Delta-9-THC and the remainder consists of unidentified more polar compounds. No data are presently available dealing with metabolic disposition of THC in experienced marihuana users.[/quote]While this study says that intravenous use of Marijuana is completely harmless. While, a study that is cited completely contradicts this claim. [URL]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1306836/?page=1[/URL] --- [quote]Both Weil (216) and Smith (192) believe that non-drug factors play the most important role in the occurrence of acute toxic reactions. That is, the effect of marihuana on the individual depends to a large extent on the interaction of drug effect with the individual's psychological makeup, expectations, attitudes, mood and the physical and emotional circumstances surrounding drug use. The great variability in these factors makes the effect of marihuana rather unpredictable in many circumstances.[/quote]While this says Marijuana itself will not cause any form of toxic reaction, while the study cited says: [quote]Adverse acute reactions to marihuana are infrequent, but physicians will see more of them as use of the drug increases and reaches new areas of society. Several very distinct types of reactions occur. In persons without a history of mental disorder who have never taken hallucinogenic drugs, marihuana may cause simple depressive reactions, panic reactions (most common) and toxic psychoses. In persons who have previously taken hallucinogens, marihuana may also trigger recurrences of hallucinogenic effects and may occasionally precipitate delayed psychotic reactions. Finally, in ambulatory schizophrenics, marihuana can cause atypical reactions, frequently marked by derealization. Most of these reactions are self-limited and benign but can be worsened by improper medical management. A few require psychiatric and psychopharmacologic intervention.[/quote]