• Stem Cells Used to Regenerate Immune Cells.
    23 replies, posted
[quote] [quote] [IMG]http://images.sciencedaily.com/2013/01/130103131112.jpg[/IMG] ============================================================ These are rejuvenated T cells dedifferentiated from the T-iPSCs in the previous image. Although T-iPSCs and these T cells share the same genome, their morphology and function are totally different. (Credit: Nishimura et al., Cell Stem Cell) [/quote] The human body contains immune cells programmed to fight cancer and viral infections, but they often have short lifespans and are not numerous enough to overcome attacks by particularly aggressive malignancies or invasions. Now researchers reporting in two separate papers in the January 4th issue of the Cell Press journal Cell Stem Cell used stem cell technology to successfully regenerate patients' immune cells, creating large numbers that were long-lived and could recognize their specified targets: HIV-infected cells in one case and cancer cells in the other. The findings could help in the development of strategies to rejuvenate patients' exhausted immune responses. The techniques the groups employed involved using known factors to revert mature immune T cells into induced pluripotent stem cells (iPSCs), which can differentiate into virtually any of the body's different cell types. The researchers then expanded these iPSCs and later coaxed them to redifferentiate back into T cells. Importantly, the newly made T cells were "rejuvenated" with increased growth potential and lifespan, while retaining their original ability to target cancer and HIV-infected cells. These findings suggest that manipulating T cells using iPSC techniques could be useful for future development of more effective immune therapies. In one study, investigators used T cells from an HIV-infected patient. The redifferentiated cells they generated had an unlimited lifespan and contained long telomeres, or caps, on the ends of their chromosomes, which protect cells from aging. This is significant because normal aging of T cells limits their expansion, making them inefficient as therapies. "The system we established provides 'young and active' T cells for adoptive immunotherapy against viral infection or cancers," says senior author Dr. Hiromitsu Nakauchi, of the University of Tokyo. The other research team focused on T cells from a patient with malignant melanoma. The redifferentiated cells they created recognized the protein MART-1, which is commonly expressed on melanoma tumors. "The next step we are going to do is examine whether these regenerated T cells can selectively kill tumor cells but not other healthy tissues. If such cells are developed, these cells might be directly applied to patients," says senior author Dr. Hiroshi Kawamoto, of the RIKEN Research Center for Allergy and Immunology. "This could be realized in the not-so-distant future." [B]Journal:[/B] Nishimura et al. Generation of rejuvenated antigen-specific T cells by pluripotency reprogramming and redifferentiation. Cell Stem Cell, Volume 12, Issue 1, 114-126, 3 January 2013 DOI: [URL="http://dx.doi.org/10.1016/j.stem.2012.11.002"]10.1016/j.stem.2012.11.002[/URL] Vizcardo et al. Regeneration of human tumor antigen-specific T cells from iPS cells derived from mature CD8 T cells. Cell Stem Cell, 2013 DOI: [URL="http://dx.doi.org/10.1016/j.stem.2012.12.006"]10.1016/j.stem.2012.12.006[/URL] ============================================================ [B]Source:[/B] [URL]http://www.sciencedaily.com/releases/2013/01/130103131112.htm[/URL] [/quote]
Stem cells are definitely the medical future.
[QUOTE=dedo678;39083127]Stem cells are definitely the medical future.[/QUOTE] Carbon nano-tubes of the medical world.
Good, soon we can become like the [url=http://en.wikipedia.org/wiki/Turritopsis_nutricula]Turritopsis nutricula.[/url]
[QUOTE=valkery;39083211]Carbon nano-tubes of the medical world.[/QUOTE] Study Says Carbon Nanotubes as Dangerous as Asbestos [2008] [url]http://www.scientificamerican.com/article.cfm?id=carbon-nanotube-danger[/url]
[QUOTE=Bradyns;39083362]Study Says Carbon Nanotubes as Dangerous as Asbestos [2008] [url]http://www.scientificamerican.com/article.cfm?id=carbon-nanotube-danger[/url][/QUOTE] Stem Cells are to Medicine what Carbon Nanotubes are to other scientific fields. That's what I meant. I didn't mean that Carbon Nanotubes should be used in medicine.
[QUOTE=valkery;39086108]Stem Cells are to Medicine what Carbon Nanotubes are to other scientific fields. That's what I meant. I didn't mean that Carbon Nanotubes should be used in medicine.[/QUOTE] In which, I retort and agree in regards to applications of Carbon Nanotubes..
Now to get these stem cells.
BUT YOU'RE MURDERING BABIES I seriously hope we can remove those morons who yell crap like that and let the future roll in.
[QUOTE]the Cell Press journal Cell Stem Cell used stem cell[/QUOTE] oh jeez
[QUOTE=Reds;39087464]BUT YOU'RE MURDERING BABIES I seriously hope we can remove those morons who yell crap like that and let the future roll in.[/QUOTE] dude, we can produce Totipotent stem cells from human skin cells...
To prevent AIDS just put some baby placenta on your condoms and the magic of stem cells will save you from most STD's!
Why are people against this? I don't understand. Are people retarded?
[QUOTE=Hullu V3;39090248]Why are people against this? I don't understand. Are people retarded?[/QUOTE] Their main reason was that it harmed babies (hint, it doesn't) But now that we can make them from blood and skin their only reason will be that we are 'playing god'.
[QUOTE=themooselord;39090523]Their main reason was that it harmed babies (hint, it doesn't) But now that we can make them from blood and skin their only reason will be that we are 'playing god'.[/QUOTE] If that's their logic then we should stop making medicine, we should stop researching how the world works. We should stop producing machinery, we should stop everything that makes us modern. Fucking retards.
Stem cells are so amazing I don't even care if it harms babies. Now please hurry up and make them cheap and available.
Carbon nano tubes made out of stem cells TIME TRAVEL
[QUOTE=proch;39091193]Carbon nano tubes made out of stem cells TIME TRAVEL[/QUOTE]Can we grow a mechanical time travel gland?
[QUOTE=proch;39091193]Carbon nano tubes made out of stem cells TIME TRAVEL[/QUOTE] I'm not saying we're going to build nano-machines But we're going to build nano-machines
[QUOTE=Reds;39087464]BUT YOU'RE MURDERING BABIES I seriously hope we can remove those morons who yell crap like that and let the future roll in.[/QUOTE] We need to invent a time machine first and send them back to the 15th century were they belong.
[QUOTE=Black;39091488]We need to invent a time machine first and send them back to the 15th century were they belong.[/QUOTE] You do know there were still a fuckton of religious nutjobs even in the 19th century right
[QUOTE=itisjuly;39091338]Can we grow a mechanical time travel gland?[/QUOTE] Only if i can tattoo the activation code on my ass
[QUOTE=BreenIsALie;39091819]Only if i can tattoo the activation code on my ass[/QUOTE] Shaped like the head of a mechanical guy I know :(
Mastering the stem cell research would result in uncovering the holy grail of modern medical science.
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