Losing weight is about to get a hell of a lot harder.. - Polidicks

[TABLE="class: outer_border, width: 600, align: left"] [TR] [TD][TABLE="width: 550, align: left"] [TR] [TD][h2]Viagra Converts Undesireable White Fat Cells Into Beige Ones in Mice: May One Day Lead to New Weight Loss Methods.[/h2][B]Researchers from the University of Bonn treated mice with Viagra and made an amazing discovery: The drug converts undesirable white fat cells and could thus potentially melt the unwelcome "spare tire" around the midriff. In addition, the substance also decreases the risk of other complications caused by obesity.[/B][/TD] [/TR] [/TABLE] [/TD] [/TR] [TR] [TD][TABLE="width: 400, align: center"] [TR] [TD="align: center"][quote][IMG]http://images.sciencedaily.com/2013/01/130117105738.jpg[/IMG][/quote][/TD] [/TR] [/TABLE] [/TD] [/TR] [TR] [TD][TABLE="width: 550, align: center"] [TR] [TD]The results are now published in The Journal of the Federation of American Societies for Experimental Biology (FASEB). Sildenafil – better known as Viagra – is used to treat erectile dysfunction. This substance prevents degradation of cyclic guanosine mono-phosphate (cGMP), which then ensures blood supply for an erection. However, another effect of Viagra has been noticed quite some time ago – mice given sildenafil over longer periods of time were resistant to obesity when fed with high-fat diet. However, the cause for this reduced weight gain had been unclear. Researchers from the University of Bonn have been able to shed some light on this sildenafil effect. "We have been researching the effect of cGMP on fat cells for quite some time now," reports Prof. Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology at the University of Bonn. "This is why sildenafil was a potentially interesting candidate for us." [B]Viagra converts undesirable white fat cells into beige ones[/B] Together with the PharmaCenter of the University of Bonn, the German Federal Institute for Drugs and Medical Devices (BfArM), and the Max Planck Institute for Heart and Lung Research, the team around Prof. Pfeifer studied the effect of sildenafil on fat cells in mice. The researchers administered the potency drug to the rodents for seven days. "The effects were quite amazing," says Dr. Ana Kilic, one of Prof. Pfeifer's colleagues. Sildenafil increased the conversion of white fat cells, which are found in human 'problem areas', into beige ones in the animals. "Beige fat cells burn the energy from ingested food and convert it to heat, says Prof. Pfeifer. Because the beige fat cells can “melt the fat” and thus fight obesity, researchers are very hopeful for their potential. [B]Positive effect on inflammation responses[/B] In addition, the researchers observed something else of interest. If white fat cells are further "stuffed"/accumulating lipids, they are increasing in size and can synthesize and release hormones which in turn cause inflammation thus increasing the persons risk for chronic diseases. Such inflammatory responses may then lead to, e.g., cardio-vascular diseases resulting in heart attacks and strokes, as well as cancer and diabetes. "It seems that sildenafil prevented the fat cells in these mice from getting onto that slippery slope," reports Prof. Pfeifer. Overall, the development of white cells seems to be healthier. [B]More than half a billion overweight people worldwide[/B] Globally, over half a billion people are overweight. Present study has resulted in interesting starting points for further research on this mechanism. "Sildenafil is not only able to minimize erectile problems, but it can also reduce the risks of gaining excessive weight," says Prof. Pfeifer. The researchers may have found a mechanism that allows converting the undesirable white fat cells into the "good" beige (brown-like) fat cells that "melt" away excess pounds. In addition, it might be possible to decrease complications related with obesity. "But this will need to be proven in additional studies," adds Dr. Kilic. [B]Caution against premature application[/B] Despite promising data, researchers caution the public against the fallacy of thinking that popping some sildenafil will work to quickly lose the extra pounds accumulated over the holidays. "We are currently in the basic research stage, and all the studies have been exclusively performed on mice," stresses Prof. Pfeifer. It will be a long way until potentially suitable drugs for decreasing white fat cells in humans will be found.[/TD] [/TR] [/TABLE] [/TD] [/TR] [TR] [TD][B]Journal: [/B] M. M. Mitschke, et al. Increased cGMP promotes healthy expansion and browning of white adipose tissue. The FASEB Journal, 2013; DOI: [URL]http://dx.doi.org/10.1096/fj.12-221580[/URL][/TD] [/TR] [TR] [TD][B]SOURCE: [/B] [URL]http://www.sciencedaily.com/releases/2013/01/130117105738.htm[/URL][/TD] [/TR] [/TABLE]

Boner AND weight loss? I'm in.

[QUOTE=Limed00d;39315813]Boner AND weight loss? I'm in.[/QUOTE] exercise = sweaty nasty stinky angry fapping

Oh, oh that pun. [url=http://www.youtube.com/watch?v=GZi4v7fk42Q]Oh boy that pun[/url]

That title.

Yeah, aspirin has fat loss benefits too. Hell I can name a slew of over the counter drugs with fat loss applications. Problem is these obese people have poor eating habits, and giving them drugs won't change that. You can't utilize fat loss drugs while still consuming 6000 calories every day.

[QUOTE=JaegerMonster;39315854] Problem is these obese people have poor eating habits, and giving them drugs won't change that. You can't utilize fat loss drugs while still consuming 6000 calories every day.[/QUOTE] This. Just eat less, it's as simple as that.

time to make my penis hard.

[QUOTE=JaegerMonster;39315854]Yeah, aspirin has fat loss benefits too. Hell I can name a slew of over the counter drugs with fat loss applications. Problem is these obese people have poor eating habits, and giving them drugs won't change that. You can't utilize fat loss drugs while still consuming 6000 calories every day.[/QUOTE] it's more the fact that people are spending all their days sitting still. you could be watching your calorie intake very well and making sure you're slim but still being unhealthy

Saw the title, thought it was new range of bacon related products or something.

God damn, Viagra is just about the best substance ever invented. And yeah, the title had me expecting a KFC Triple Down announcement or something.

[QUOTE=Limed00d;39315813]Boner AND weight loss? I'm in.[/QUOTE] If weight loss persists for more than four hours consult your physician.

i once was skinny, but now. i will never look back

Yeah it's actually easy.Just stop eating and bam that belly will soon go away

You don't even have to eat less; simple exercise can counteract that with smarter eating.

Its not so easy when you stuck in your chair

[QUOTE=NotMeh;39315870]This. Just eat less, it's as simple as that.[/QUOTE] That doesn't really solve the problem though. If you eat less your body may see that as a sign of "I'm not feeding myself, better store everything I eat into fat".

[QUOTE=gbtygfvyg;39316927]That doesn't really solve the problem though. If you eat less your body may see that as a sign of "I'm not feeding myself, better store everything I eat into fat".[/QUOTE] I said eat less, not go into full starvation mode. I don't get why people think being on a diet means eating a slice of bread a day.

Or you know, go for a 1 hr jog/walk every day.

That fucking title. Also, I'm trying to gain weight, but it's hard because I have no appetite for anything ever.

[QUOTE=Sub-Zero;39316902]Yeah it's actually easy.Just stop eating and bam that belly will soon go away[/QUOTE] you will die if you stop eating

[i]Feel the burn![/i]

So in theory, if one supplements their everyday workout with a bit of viagra, they could potentially lose weight faster than normal? Sounds useful, but surely viagra has at least a few side-effects, aside from being hard for a while and the relevant "contraindications" (reason to withhold a certain kind of treatment).

I've got this vision of obese people walking around outside everywhere rocking huge boners while wearing sweatpants

As much as it lacks the comedy I'm quite sure if this was adapted into a weight loss drug they'd isolate the weight loss part and not have it give you boners sorry [editline]22nd January 2013[/editline] [QUOTE=JaegerMonster;39315854]Yeah, aspirin has fat loss benefits too. Hell I can name a slew of over the counter drugs with fat loss applications. Problem is these obese people have poor eating habits, and giving them drugs won't change that. You can't utilize fat loss drugs while still consuming 6000 calories every day.[/QUOTE] Drugs that reduce appetite are likely better candidates for weight loss. Reduced appetite was a side effect of something I was on a while ago and the difference was absolutely shocking, I didn't notice a difference in how much I was eating at first but when I started keeping track I realized I was clearly eating less. Most people in the moderately overweight and moderately underweight category likely under and overestimate how much they eat respectively, you're right there.

[QUOTE=gbtygfvyg;39316927]That doesn't really solve the problem though. If you eat less your body [B]may see that as a sign of "I'm not feeding myself, better store everything I eat into fat".[/B][/QUOTE] This is the single biggest myth about weight loss ever created. An increase in metabolic rate and production of nervous system stimulating hormones is seen during fasting.

[QUOTE=redBadger;39316908]You don't even have to eat less; simple exercise can counteract that with smarter eating.[/QUOTE] BOOOOOORING

[QUOTE=Zeke129;39318869]As much as it lacks the comedy I'm quite sure if this was adapted into a weight loss drug they'd isolate the weight loss part and not have it give you boners sorry [editline]22nd January 2013[/editline] Drugs that reduce appetite are likely better candidates for weight loss. Reduced appetite was a side effect of something I was on a while ago and the difference was absolutely shocking, I didn't notice a difference in how much I was eating at first but when I started keeping track I realized I was clearly eating less. Most people in the moderately overweight and moderately underweight category likely under and overestimate how much they eat respectively, you're right there.[/QUOTE] Yeah there are plenty of appetite suppressing drugs, but I think the problem with truly obese people is that a lot of them are habitual/comfort eaters.

[QUOTE=Laserbeams;39317083]you will die if you stop eating[/QUOTE] [media]http://www.youtube.com/watch?v=jPsKpnu0-X4[/media]

[QUOTE=Laserbeams;39317083]you will die if you stop eating[/QUOTE] You can also throw up and bam