Do you even lift?! Well, now you don't have to (hopefully).. - Polidicks

[quote] [B][h2]Protein Linking Exercise to Bigger, Stronger Muscles Discovered; Finding Might Lead to New Therapies for Muscle-Wasting Diseases[/h2][/B] [quote] [IMG]http://images.sciencedaily.com/2012/12/121206121728.jpg[/IMG] ============================================================ Scientists at Dana-Farber Cancer Institute have isolated a previously unknown protein in muscles that spurs their growth and increased power following resistance exercise. (Credit: © Mircea Netea / Fotolia) [/quote] Scientists at Dana-Farber Cancer Institute have isolated a previously unknown protein in muscles that spurs their growth and increased power following resistance exercise. They suggest that artificially raising the protein's levels might someday help prevent muscle loss caused by cancer, prolonged inactivity in hospital patients, and aging. Mice given extra doses of the protein gained muscle mass and strength, and rodents with cancer were much less affected by cachexia, the loss of muscle that often occurs in cancer patients, according to the report in the Dec. 7 issue of the journal Cell. "This is basic science at present," commented Jorge Ruas, PhD, first author of the report. "But if you could find a way to elevate levels of this protein, that would be very exciting. For example, you might be able to reduce muscle wasting in patients in intensive care units whose muscles atrophy because of prolonged bed rest." Other applications, he said, might be in disorders such as muscular dystrophy and the gradual loss of muscle mass from aging. Bruce Spiegelman, PhD, the senior author, led the Dana-Farber team that identified the protein, PGC-1 alpha-4, in skeletal muscle and said it is present in mice and humans. Resistance exercise, such as weight lifting, causes a rise in PGC-1 alpha-4, which in turn triggers biochemical changes that make muscles larger and more powerful, said the researchers. The protein is an isoform, or slight variant, of PGC-1 alpha, an important regulatory of body metabolism that is turned on by forms of exercise, such as running, that increase muscular endurance rather than size. "It's pretty amazing that two proteins made by a single gene regulate the effects of both types of exercise," commented Spiegelman. The researchers found that the new protein controls the activity of two previously known molecular pathways involved in muscle growth. A rise in PGC-1 alpha-4 with exercise increases activity of a protein called IGF1 (insulin-like growth factor 1), which facilitates muscle growth. At the same time, PGC-1 alpha-4 also represses another protein, myostatin, which normally restricts muscle growth. In effect, PGC-1 alpha-4 presses the accelerator and removes the brake to enable exercised muscles to gain mass and strength. "All of our muscles have both positive and negative influences on growth," Spiegelman explained. "This protein (PGC-1 alpha-4) turns down myostatin and turns up IGF1." Several experiments demonstrated the muscle-enhancing effects of the novel protein. The investigators used virus carriers to insert PGC-1 alpha-4 into the leg muscle of mice and found that within several days their muscle fibers were 60 percent bigger compared to untreated mice. They also engineered mice to have more PGC-1 alpha-4 in their muscles than normal mice who were not exercising. Tests showed that the treated mice were 20 percent stronger and more resistant to fatigue than the controls; in addition, they were leaner than their normal counterparts. Mice engineered to have extra PGC-1 alpha-4 showed "dramatic resistance" to cancer-related muscle wasting, the scientists found. The mice lost only 10 percent mass in a leg muscle compared to a 29 percent loss in mice with cancer that did not have additional PGC-1 alpha-4, according to the report. The altered mice were also stronger and more active than the normal mice. Ruas, the first author, is now in the faculty at the Karolinska Institute in Sweden. Other authors are from Dana-Farber Cancer Institute, Harvard Medical School, the University of Colorado, the University of Virginia, and the Mayo Clinic. The research was supported by NIH grant DK061562 and a grant from Novartis. Journal: Jorge L. Ruas, et al. A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy. Cell, 2012; 151 (6): 1319 DOI: [URL="http://www.cell.com/retrieve/pii/S0092867412013633"]10.1016/j.cell.2012.10.050[/URL] ============================================================ Source: [URL]http://www.sciencedaily.com/releases/2012/12/121206121728.htm[/URL] [/quote]

Weight-lifting protein? BROTEIN But really, this is an awesome advancement

oddly enough I was thinking yesterday of what the effects of what muscle growth pills would do to the body building community. I came to the conclusion it would just become some hipster practice.

I wonder if it would really come to people taking pills and becoming stronger on the go. What the fuck would happen to us then, imagine everyone being supersoldiers (Strength-wise) on the street. It will be only a matter of wealth how strong a person is, who could afford the bigger amount.

[QUOTE=Vasili;38735189]oddly enough I was thinking yesterday of what the effects of what muscle growth pills would do to the body building community. I came to the conclusion it would just become some hipster practice.[/QUOTE] "BRO DO YOU EVEN LIFT" "yeah but like, only ironically. see i take these pills that lift for me and then i lift just because it doesn't do anything." "BRO . . . THAT'S. WOW. OK." [editline]7th December 2012[/editline] [QUOTE=Dark RaveN;38735198]I wonder if it would really come to people taking pills and becoming stronger on the go. What the fuck would happen to us then, imagine everyone being supersoldiers (Strength-wise) on the street. It will be only a matter of wealth how strong a person is, who could afford the bigger amount.[/QUOTE] just like how rich people don't get headaches because they can afford more aspirin

[QUOTE=Mr. Scorpio;38735207] just like how rich people don't get headaches because they can afford more aspirin[/QUOTE] witty yet completely irrelevant. the effect of aspirin doesn't stack.

[QUOTE=Vodkavia;38735230]This would most definitely be useful for long term space travel. At the same time my paranoid side makes me wonder if there are any horrible side effects not yet discovered.[/QUOTE] it causes boneitis

reminds me of [media]http://www.youtube.com/watch?v=qRuNxHqwazs[/media] [editline]7th December 2012[/editline] [QUOTE=timmah638;38735164]Weight-lifting protein? BROTEIN But really, this is an awesome advancement[/QUOTE]

That guys got no arms WEAK

This sounds extremely useful for astronauts as a major concern of prolong time in space is muscle deterioration.

[QUOTE=sedarahC;38735423]This sounds extremely useful for astronauts as a major concern of prolong time in space is muscle deterioration.[/QUOTE] austronauts just need more SQUATS AND MILK

For some reason i was always ridiculously strong. All i did was sit at home playing video games and eat mcdonalds twice a week like a fat lazy piece of shit. Like, i could lift 2 people at once with ease. So thank you mcdonalds and video games for already doing lifting for me.

every day is an upper body day

Every day is a full body day. Squats every day, bench presses and overhead presses alternating. EDIT: Not every day. Three days of workout, M-W-F. Lots of rest days for maximum growth.

this is interesting [B]but[/B] i don't think you'll be able to just shoot up protein three times a week and get the gainz.

I have friends that lift every single day, no rest and eat 2-3 shakes of Mutant Mass and creatine supplements to get those gains. Funny thing is they really don't gain much at all

I'm trying to get into the habit of exercising. I want to be strong too... [img]http://i.somethingawful.com/forumsystem/emoticons/emot-smith.gif[/img]

There's already a shortcut, it's called steroids. There's a reason for the stigma.

Do you even PGC-1 alpha-4?

[QUOTE=wug;38735508]For some reason i was always ridiculously strong. All i did was sit at home playing video games and eat mcdonalds twice a week like a fat lazy piece of shit. Like, i could lift 2 people at once with ease. So thank you mcdonalds and video games for already doing lifting for me.[/QUOTE] I'm sorta the opposite to you. I work out time to time and I have sorta buff arms, but I still can't lift for shit. I sorta lift

Well, this doesnt remove fat, right? So facepunch would still have to go run a few miles a day and take these pills.

"Protein Linking Exercise to Bigger, Stronger Muscles Discovered; Finding Might Lead to New Therapies for Muscle-Wasting Diseases" FUCK THAT LET'S GET RIPPED

[QUOTE=Foogooman;38737989]"Protein Linking Exercise to Bigger, Stronger Muscles Discovered; Finding Might Lead to New Therapies for Muscle-Wasting Diseases" FUCK THAT LET'S GET RIPPED[/QUOTE] One could say you'd get ripped. [i]Ripped off.[/i]

For some reason, this article just chucked some demotivation into my gym routine now. I'm imagining so many people getting buff and those who trained to be where they are are just ignored. Hopefully it will never be released for public use where anyone can buy it anywhere.

[QUOTE=Flyingman356;38737435]There's already a shortcut, it's called steroids. There's a reason for the stigma.[/QUOTE] Thought the main problem with them was all the nasty side effects?

[QUOTE=koeniginator;38738028]One could say you'd get ripped. [i]Ripped off.[/i][/QUOTE] boooooo

Sensationalist headlines scum, Witness the Fitness is the true master race.

[QUOTE=Flyingman356;38737435]There's already a shortcut, it's called steroids. There's a reason for the stigma.[/QUOTE] The reason that steroids give you increased muscle mass is because it increases your body's testosterone levels, which helps when building muscle, and not by modifying proteins in your genes. There's no reason to assume this will have the same side effects because it's an entirely different process.

[QUOTE=Dark RaveN;38735266]witty yet completely irrelevant. the effect of aspirin doesn't stack.[/QUOTE] yeah and taking extreme amounts of protein pills would probably kill you.

According to the article you still have to lift, bra.