• Researchers unravel mechanism that plays key role in sexual differentiation of brain
    100 replies, posted
[QUOTE]During prenatal development, the brains of most animals, including humans, develop specifically male or female characteristics. In most species, some portions of male and female brains are a different size, and may have a different number of neurons and synapses. However, scientists have known little about the details of how this differentiation occurs. Now, a new study by researchers at the University of Maryland School of Medicine (UM SOM) has illuminated details about this process. Margaret McCarthy, PhD, professor and chairman of the Department of Pharmacology, studied brain development in newborn rats. She found that giving estradiol, a testosterone derivative, triggers a mechanism by which certain genes in the brain are “unsilenced,” allowing them to initiate the process of masculinization. This process involves a group of enzymes known as DNA methyltransferases, or Dnmts, which modify DNA to repress gene expression. Prof. McCarthy and Nugent also found that inhibiting Dnmts has powerful effects, even outside the usual window of development. During prenatal development there is a restricted time frame during which the brain takes on male or female characteristics. Scientists had thought that once this window closed, it could not be reopened. But the two researchers found otherwise. They succeeded in transforming the brain of a female rat after the window had closed, giving it the characteristics of a male rat brain. Prof. McCarthy and Nugent injected Dnmt inhibitors into a specific region of the female brains, a region known as the preoptic area, or POA. In every species that’s been studied, including humans, the POA plays a key role in governing male sexual behavior. The injections occurred after the first week of birth, the time when the window for brain sexual differentiation was thought to have been closed. Despite this, the preoptic area in these animals was transformed, and took on structural characteristics of a male rat. The female rats also behaved differently, displaying sexual behavior typical of male rats. In another experiment, they genetically deleted the Dnmt gene in female mice; these animals also showed male behavior patterns.[/QUOTE] [url]http://www.psypost.org/2015/03/researchers-unravel-mechanism-that-plays-key-role-in-sexual-differentiation-of-brain-32986[/url]
So basically, we found the On/Off switch of basically turning a person straight or gay.
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] It could possibly cause some Religious group to create some weird law that forces people to do this, but i believe that would not be allowed though. But, it could possible in the future for somebody who wants to change their sexual identity for the hell of it.
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] I'm sure the majority of trans people you ask would rather not have been born trans and have to go through the pain and dissatisfaction of a sex change. I bet if this operation were cheaper than a sex reassignment surgery a lot of people would just opt to cure their body dysmorphia.
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] this is just changing the sexual behavior from female to male you can go from female -> male but not the other way
[QUOTE=TheFifthWheel;47443135]I'm sure the majority of trans people you ask would rather not have been born trans and have to go through the pain and dissatisfaction of a sex change.[/QUOTE] that's true. it's also true that most GiD males given the choice would still rather be female unless they could start life over again I could only imagine the mental struggle I would go through if I had all of these years of pleading to be a woman just to have some shot that essentially removes what is a huge part of my identity and life
yeah but this only changes the sexual behavior from straight to lesbian in female brains. i don't get what's so scary exactly when this is just experimental and no-one will ever be forcing anyone to go through this also the thing is that transgendered individuals' brains are more of the opposite gender anyway
yeah i fixed it to sexual behavior which is specifically what is said in the article
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] This is going to sound really shitty, but is that necessarily a terrible thing? A lot of the emotional and mental problems that people in the LGBT face are a result of not feeling like they fit in, being treated differently (terribly, even), etc, etc. If you could make sure that children grew up to have the corresponding mental traits for their physical characteristics so that those specific worries no longer existed you could probably remove a large portion of the depression from the population. It's basically another version of the whole, "if you could be dumb and always happy, would you be?" question; if you could retrospectively pick a way of existence that would ensure your happiness and you'd never know the difference, would you do so? No matter how 'good' we become as people, no matter how much better society becomes, there'll always be cunts around that perpetuate those negative feelings in people who they perceive as different from themselves.
xchange pills becoming reality, nobody would have thought.
Better yet, we could later do this in the womb, so we needn't worry with harming LGBT people.
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] I don't see it as a bad thing. If everyone could safely turn from gay to male it would only be for the better. No more discrimination, acceptance and self hate problems.
but muh agenderbifluidism [highlight](User was banned for this post ("trolling/dumb post" - dai))[/highlight]
It would be interesting if this was used as a counter measure against overpopulation. I know it would be inhumane for one thing.
[QUOTE=PelPix123;47443128]May not be allowed is a pretty big leap of logic to make. Maybe not in America, but in some place somewhere else, possibly, in the future. What if a new eugenics party takes over a country some time in the future, like a second Nazi Germany? They'd be very interested in this tech. Even though we'd be safe, we wouldn't be able to stop them doing this to [I]their own[/I] citizens because of mutually assured destruction. They'd be able to do whatever they wanted as long as they threatened thermonuclear war. Mutually assured destruction preventing war can be bad in cases like this, because sometimes war is the only way to stop someone.[/QUOTE] If you're this worried about other countries doing bad things and wanting them resolved, then would you advocate we invade every tinpot dictatorship out there? Would you have advocated a strong military response when the PRC shot their own people in 1989, or 2011 during the Arab Spring? Rwanda genocide or Mexican cartels?
[QUOTE=PelPix123;47443481]Not necessarily, but MAD makes things complicated. What would we have been able to do about Nazi Germany if atomic bombs were invented earlier instead of later?[/QUOTE] Well considering the circumstances the Germans were in they would have probably used them anyways by the time the Americans got involved. The USSR would have almost certainly have deployed them in an offensive role at some stage too if they had them. If a future country went out and started practicing eugenics, then who are we to invade it? As long as the party gained power through free and fair elections, while the policy held widespread popular support within that nation, I don't think it's our right to go invading that place.
[QUOTE=MuffinZerg;47443452]I don't see it as a bad thing. If everyone could safely turn from gay to male it would only be for the better. No more discrimination, acceptance and self hate problems.[/QUOTE] Or maybe people could just stop caring about where other people put their cocks? Also, what the fuck, like going from gay to male doesn't even make sense, on any level whatsoever. Look, if people want to go through with this, that's great, more power to them, set an age limit so you don't have parents pushing their kids into it. Although really this is just the start, we've managed to prove that in vivo genome editing is possible in mice too so really we're only witnessing the starts of major gene editing technology as it hits the market.
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] so what it really doesn't make a difference. Leaving a transexual person to develop unaided when you could easily stop it could prevent a lifetime of self-loathing and body anxiety, I don't see anything bad about that.
[QUOTE=Deathtrooper2;47443115]It could possibly cause some Religious group to create some weird law that forces people to do this, but i believe that would not be allowed though. But, it could possible in the future for somebody who wants to change their sexual identity for the hell of it.[/QUOTE] But what if we found the on/off switch for believing in religions?
[QUOTE=V12US;47443623]But what if we found the on/off switch for believing in religions?[/QUOTE] Yeah man who even needs the free will to make decisions regarding your own genome.
The bait game is stagnant
[QUOTE=MuffinZerg;47443452]I don't see it as a bad thing. If everyone could safely turn from gay to male it would only be for the better. No more discrimination, acceptance and self hate problems.[/QUOTE] That comment is precise the problem. People who mark gay as a disease. I got nothing against the development, but people who are still stuck in 1973 might abuse this to force a gender onto their kids. We can see countless examples of parents stuffing their kids with bleach, cause 1 ex-doctor said it might cure Alzheimer. I can only see the positive if doctors are the only one, who can access and 'treat' people over 18. The problem is not being gay .. the problem are [b]people[/b] who [b]mark[/b] it as a problem. Being gay is as natural as a being straight. Even animals know that.
[QUOTE=Saturn V;47443151]this is just changing the sexual behavior from female to male you can go from female -> male but not the other way[/QUOTE] No they did it both ways making a female rat brain male and a male rat brain female [editline]2nd April 2015[/editline] Still rat brains are not nearly as close an analogue to human brains, I doubt this will ever be allowed to progress into anything humans can use because that would involve embryonic trials with the brain developing which we cannot do for religious and ethical reasons
[QUOTE=Sableye;47443722]No they did it both ways making a female rat brain male and a male rat brain female [editline]2nd April 2015[/editline] Still rat brains are not nearly as close an analogue to human brains, I doubt this will ever be allowed to progress into anything humans can use because that would involve embryonic trials with the brain developing which we cannot do for religious and ethical reasons[/QUOTE] Naw man we can do shit in vivo now and it will happen sooner or later considering the sheer number of genetic diseases that could be treated with it. Like I don't even get how people hold that sort of idea, genetic therapy is already here and the second we can use it in vivo, in humans with a good degree of accuracy it will be used.
[QUOTE=sltungle;47443202]This is going to sound really shitty, but is that necessarily a terrible thing? A lot of the emotional and mental problems that people in the LGBT face are a result of not feeling like they fit in, being treated differently (terribly, even), etc, etc. If you could make sure that children grew up to have the corresponding mental traits for their physical characteristics so that those specific worries no longer existed you could probably remove a large portion of the depression from the population. It's basically another version of the whole, "if you could be dumb and always happy, would you be?" question; if you could retrospectively pick a way of existence that would ensure your happiness and you'd never know the difference, would you do so? No matter how 'good' we become as people, no matter how much better society becomes, there'll always be cunts around that perpetuate those negative feelings in people who they perceive as different from themselves.[/QUOTE] Funny thing is that the researchers have basically identified why transgender people exist, not how to cure them. Because if you read, you got a male rat in a female's body due to a hormone mishap.
[QUOTE=PelPix123;47443103] If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] I see a new James Bond film on the horizon.
[QUOTE=Deng;47443521]Well considering the circumstances the Germans were in they would have probably used them anyways by the time the Americans got involved. The USSR would have almost certainly have deployed them in an offensive role at some stage too if they had them. If a future country went out and started practicing eugenics, then who are we to invade it? As long as the party gained power through free and fair elections, while the policy held widespread popular support within that nation, I don't think it's our right to go invading that place.[/QUOTE] "i don't know what human rights are"
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] Let's look at the brighter side of things, yeah? There exists homosexuals and transsexuals who don't wish to be who they are, a "switch" would allow them a better life. For example, the route as a transsexual isn't the easiest - they'd be able to choose a stalling alternative until treatment's been better developed.
[QUOTE=Zeke129;47443924]I see a new James Bond film on the horizon.[/QUOTE] "Do you expect me to talk?" "No Mr. Bond, I expect you to spend some time grappling awkwardly with your new sexual desires!"
[QUOTE=PelPix123;47443103]This is a little terrifying. If this is true, then couldn't this be used to 'cure' transgender and gay people of their 'condition'? Both homosexuality and transsexuality are due in part to this process happening 'incorrectly'. If science can re-happen it now, doesn't that mean that transgenderism and homosexuality could be reversed? If this tech gets into the hands of some genuinely evil people, we could see the utter extinction of the LGBT community.[/QUOTE] You could also play pranks on people by making them gay for a day.
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