Molecular Trigger for Alzheimer's Disease Identified
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[url]http://www.sciencedaily.com/releases/2013/05/130520154217.htm[/url]
[IMG]http://images.sciencedaily.com/2013/05/130520154217-large.jpg[/IMG]
[QUOTE][B]Researchers have pinpointed a catalytic trigger for the onset of Alzheimer’s disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons in the brain.[/B]
For the first time, scientists at Cambridge’s Department of Chemistry have been able to map in detail the pathway that generates “aberrant” forms of proteins which are at the root of neurodegenerative conditions such as Alzheimer’s.
They believe the breakthrough is a vital step closer to increased capabilities for earlier diagnosis of neurological disorders such as Alzheimer’s and Parkinson’s, and opens up possibilities for a new generation of targeted drugs, as scientists say they have uncovered the earliest stages of the development of Alzheimer’s that drugs could possibly target.
The study, published today in the Proceedings of the National Academy of Sciences, is a milestone in the long-term research established in Cambridge by Professor Christopher Dobson and his colleagues, following the realisation by Dobson of the underlying nature of protein ‘misfolding’ and its connection with disease over 15 years ago.
The research is likely to have a central role to play in diagnostic and drug development for dementia-related diseases, which are increasingly prevalent and damaging as populations live longer.
“There are no disease modifying therapies for Alzheimer’s and dementia at the moment, only limited treatment for symptoms. We have to solve what happens at the molecular level before we can progress and have real impact,” said Dr Tuomas Knowles, lead author of the study and long-time collaborator of Professor Dobson.
“We’ve now established the pathway that shows how the toxic species that cause cell death, the oligomers, are formed. This is the key pathway to detect, target and intervene – the molecular catalyst that underlies the pathology.”[/QUOTE]
First steps to funding a cure I hope. Thank god because alzhimers is a sad disease to watch happen.
My worst nightmare is to be ereased.
So yeah, this is good news.
my grandmother can't even walk or talk anymore. she has the conscience of a 2 year old and it hurts a lot to see it.
i know it's good news but it sucks to see these things popping out only now. at least it will potentially prevent or delay alzheimers in the future, because it's a cruel disease!
My great grandmother is 94 and has alzheimers, she is not the same woman i grew up with anymore and it kills me every time I visit, i'm glad to see more successes in its research.
People deep into Alzheimers are basically dead already, good that theres progress towards finding a cure.
Watch as, just like every other medical discovery posted here, it's forgotten in a week or two and never heard from again.
Seriously though, this is great! I hope they find a cure soon.
[QUOTE=Winters;40726334]First steps to funding a cure I hope. Thank god because alzhimers is a sad disease to watch happen.[/QUOTE]
My granddad had Alzheimer's when I was in sixth grade. Fortunately, he didn't die from it.
He died of a heart attack instead.
[QUOTE=Last or First;40731158]Watch as, just like every other medical discovery posted here, it's forgotten in a week or two and never heard from again.
Seriously though, this is great! I hope they find a cure soon.[/QUOTE]
And que the ignoramuses who seemingly haven't the capacity to understand medical drugs aren't just stirred up, packaged and sold to people straight out of the lab. TRIALS, man. The link was discovered 15 years ago. It'll take another 15, if not more, to validate whether or not this is a viable treatment option. Goddammit, dude, have some perspective.
[QUOTE=Winters;40726334]First steps to funding a cure I hope. Thank god because alzhimers is a sad disease to watch happen.[/QUOTE]
Thank Science.
It should be a thing.
[QUOTE=just-a-boy;40732827]And que the ignoramuses who seemingly haven't the capacity to understand medical drugs aren't just stirred up, packaged and sold to people straight out of the lab. TRIALS, man. The link was discovered 15 years ago. It'll take another 15, if not more, to validate whether or not this is a viable treatment option. Goddammit, dude, have some perspective.[/QUOTE]
[sub][sub]It's a joke on people always saying that in threads
"Forgotten"? Alzheimer's?
I did say "seriously though".
I honestly don't blame people for not getting it though.
If I hadn't posted it, I don't think even [I]I[/I] would get it.
Now that I'm think about it, if I didn't have "just like every other medical discovery posted here", it would be [B]more[/B] clear that I'm joking. Even though I put that there to try and make it more obvious I was joking. I wanted to put something along the lines of "Man, I wish we could find some way to stop people from forgetting things so often", but I thought it would make it too obvious.[/sub][/sub]
This has been [I]"Behind the Last or First post"[/I], a Last or First post about posts by Last or First. Tune in next time whenever I make another post that not even a CIA code breaker would get.
Unless if I forget.
I hope they get rid of this bastard, no family should have to watch this, and no one deserves to have memories removed from them, fuck this disease.
[QUOTE=Reshy;40726096][URL]http://www.sciencedaily.com/releases/2013/05/130520154217.htm[/URL]
[IMG]http://images.sciencedaily.com/2013/05/130520154217-large.jpg[/IMG][/QUOTE]
OH MY GOD! Please have trials.. My grandma needs help. x.x
[QUOTE=MenteR;40726438]my grandmother can't even walk or talk anymore. she has the conscience of a 2 year old and it hurts a lot to see it.
i know it's good news but it sucks to see these things popping out only now. at least it will potentially prevent or delay alzheimers in the future, because it's a cruel disease![/QUOTE]
And my grandma is the same way. She can walk but she chooses not too because she's afraid of falling or whatever and she's gotten really stubborn and does things like a toddler would do. She's starting to forget family members she didn't even remember me for about an hour.. Does your grandma have Alzheimers related dementia?
I may have Alzheimer's, but at least I don't have Alzheimer's!
Hopefully in the next 10 years Alzheimer's will be a thing of the past.
[editline]22nd May 2013[/editline]
[QUOTE=Mechwarrior;40733678]OH MY GOD! Please have trials.. My grandma needs help. x.x[/QUOTE]
Unfortunately it doesn't really work that way, I am sorry.
My grandpa's side struggled heavily with this disease. I hope a cure or preventative is found for it for my mother's sake. I don't think I could stand to see it happen to her after watching my grandpa deteriorate away.
My grandmother now lives with us because she has Alzheimer and can't stay alone anymore, I'm so scared that some day, she might wake up and not recognize me and my mother anymore.
I know it's probably too late to cure her or old people who have it, I just hope we find something to eradicate this shit quick.
good. Now lets cure the fuck out of this shit
[QUOTE=Last or First;40731158]Watch as, just like every other medical discovery posted here, it's forgotten in a week or two and never heard from again.
Seriously though, this is great! I hope they find a cure soon.[/QUOTE]
what do you want? A fucking cure to go on the market the next day?
i have it in my family so i really hope this comes to fruition before my twilight years
My uncle has alzheimer. He's a massive alcoholic too. He still remembers people, though sometimes he has to try really hard to remember somebody, but when he does, he remembers everything. He has forgotten me a couple of times, but then suddenly comes up to me and says "Bah, yeah, I do remember you" and remembers the tiniest details.
Though he doesn't remember his mom or dad, who are dead. I guess he has to see the person every now and then to actually remember them for longer.
Thank science.
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