Hi, ive recently started a prescription, called Citlopram, to help me with my Anxiety, some sort of antidepressant.
I know that alchool and citalopram can be pretty bad, and a bit lethal (God damnit!) , but i was wondering what about MDMA, mush and LSD, anyone got any experience with this medication? Or else if someone know what it does?
Thank you.
Citlopram is an SSRI which do reduce the effects produced by most psychedelics and usually it takes a larger dose to get the regular effects and uh since it is an SSRI and you take dxm you are putting yourself at risk of seritonin syndrome, which I can tell you from a personal stand point is not fun. If you plan on tripping any time soon, start to ease off the drug about a week before so you can get the full effects of whatever drug it is.
I see, no go for me. :crying:
i got prescribed to citalopram because a psychiatrist thought i was depressed.
i refused to take this medicine and started to smoke weed.
my life is better now
[QUOTE=alx12345;27605383]I see, no go for me. :crying:[/QUOTE]
Send it to me instead.
Alcohol should not be an issue on an SSRI. Not sure who told you that.
DXM is really fucking dangerous on an SSRI, but MDMA and LSD are unlikely to cause problems. Just be careful with dosing.
Protip: Don't take SSRIs at all because they fuck you up bad in withdrawal. You shouldn't be taking MDMA when you're depressed anyway, but you won't listen to me.
[QUOTE=brianosaur;27606662]i got prescribed to citalopram because a psychiatrist thought i was depressed.
i refused to take this medicine and started to smoke weed.
my life is better now[/QUOTE]
I was prescribed Citalopram, too. Just through out a full bottle of the shit this morning. I refused to fucking touch it.
SSRIs are disgusting fucking drugs.
And Dan, SSRIs have a tendency to potentiate alcohol.
SSRI Interactions:
Alcohol: Hits harder (personal experience of myself, my girlfriend, and one of my close friends)
Marijuana: Not really any noticeable effect. If anything, the high is just more relaxed
Psychedelics: Effects will be SIGNIFICANTLY reduced. Not even worth it
DXM: Serotonin Syndrome ahead!
I have heard the potentiation story but it's certainly not dangerous. I drank alcohol when on Sertraline and didn't feel any potentiation. I think they feed us the story because you shouldn't be drinking that much when depressed to start with.
Both my girlfriend and my friend notice (and noticeably exhibit) potentiation.
Dangerous? No, not really. But they do get drunk much quicker, and get much drunker, than they should for how much they drink.
Ive noticed that i am getting tired when i drink, not really sure, because i was mixing weed and alchool most of the time.
Careful
I dont know how itd affect you, but the VA gave my dad celexa, which is the name brand for citalopram, and its made my mom and I's lives aloooot fuckin better. He used to be super stressed out all the time, yelling about the dumbest shit, punishing me for stupid shit, just generally being a hard to live with asshole, and its calmed him down, it makes him feel better cause hes not stressed and anxious all the time which in turn makes our lives much more peaceful. So yea, in the right cases these weird ssri's n shit are actually quite effective.
bit of weed woulda fixed his problems too.
but glad it worked out for you guys.
Personally my depression is not due to chemical imbalance. My doctor actually understands this and respects my opinion of SSRIs. As such as he has not tried to fob me off with silly drugs.
Recent researches implies that depression may actually be due to an abundance of serotonin rather than a lack of it. SSRIs appear to help due to downregulating serotonin receptors.
when it all boils down to it it's really all about the chemicals.
That would explain why depression often goes hand-in-hand with lethargy and fatigue
[editline]25th January 2011[/editline]
[QUOTE=NeoSeeker;27658571]when it all boils down to it it's really all about the chemicals.[/QUOTE]
Life itself boils down to that
All we are is a chemical process
:smug:
[QUOTE=NeoSeeker;27658571]when it all boils down to it it's really all about the chemicals.[/QUOTE]
I vehemently disagree. Chemicals are just an aspect of depression. I do not think that depression is due to neurotransmitter population. The issue is that some people have different receptor densities in their brain. If I have low D2 receptor density I am susceptible to schizophrenia which is a widely accepted hypothesis. If I take a dopaminergic releaser I will agonise D1, D2, D3, D4 and D5 receptors causing massive central and peripheral side effects. Selective agonists are few and far between but if we can master selective agonism we can combat depression much more effectively.
[QUOTE=Anubis678;27658578]That would explain why depression often goes hand-in-hand with lethargy and fatigue
[/QUOTE]
it's not really that simple i think. neurotrasmitters effect more than one system and those systems control many different things.
mdma causes your brain to flood with serotonin right? and it's basically a psychedelic upper or some shit like that.
the brain is much more complicated than people in FPDD seem to think
and don't get me wrong, i don't know very much about the brain either. i plan on being an actor or a musician, not a brain doctor or whatever
[editline]25th January 2011[/editline]
[QUOTE=Dan The Man;27658632]I vehemently disagree. Chemicals are just an aspect of depression. I do not think that depression is due to neurotransmitter population. The issue is that some people have different receptor densities in their brain. If I have low D2 receptor density I am susceptible to schizophrenia which is a widely accepted hypothesis. If I take a dopaminergic releaser I will agonise D1, D2, D3, D4 and D5 receptors causing massive central and peripheral side effects. Selective agonists are few and far between but if we can master selective agonism we can combat depression much more effectively.[/QUOTE]
when i say it boils down to the chemicals i mean the receptors, neurotrasmitters and all that other shit.
what i thought you were talking about was your own thoughts and shit, not anything to do with your brain's composition or whatever if that makes sense
[QUOTE=NeoSeeker;27658639]mdma causes your brain to flood with serotonin right? and it's basically a psychedelic upper or some shit like that.[/QUOTE]
It also causes the release of norepinephrine and dopamine.
[QUOTE=NeoSeeker;27658639]it's not really that simple i think. neurotrasmitters effect more than one system and that system controls many different things.
mdma causes your brain to flood with serotonin right? and it's basically a psychedelic upper or some shit like that.
the brain is much more complicated than people in FPDD seem to think[/QUOTE]
The brain is unimaginably complex but you've just simplified MDMA.
MDMA is dopamine, serotonin AND norepinepherine releaser. The dopamine provides stimulation and euphoria. The serotonin provides tactile augmentation and empathy and the norepinepherine causes stimulation and peripheral side effects.
MDMA also releases oxytocin and the serotonin abundance is caused due to a reversal of the uptake mechanism in the brain. MDMA causes serotonin synapses to RELEASE rather than receive the serotonin in the brain. The neurotoxicity is mostly due to the simultaneous dopamine and serotonin release as dopamine can get trapped in serotonin receptors. This is the common theory anyway.
MDMA is a very complex drug. Almost all enctactogens are immensely complicated due to their three important neurotransmitter releases.
Dan, where have you learned all of this?
Give me 10 30 mg adderalls, the internet and three days and i could become a mini expert at just about anything
[QUOTE=Anubis678;27658791]Dan, where have you learned all of this?[/QUOTE]
I browse bluelight and drugs-forum a LOT. I know a lot of background about the majority of drugs out there as it's a big hobby of mine. I wouldn't post if I wasn't sure that my information is backed up.
I recommend browsing bluelight and drugs-forum. There's a wealth of knowledge available. There's tonnes of scientific papers too. I also plan on doing a neuroscience course on the open university in May.
Have you taken any psychology courses while at a university or ever thought of taking some?
[QUOTE=buffalo bill;27659026]Have you taken any psychology courses while at a university or ever thought of taking some?[/QUOTE]
Nope. I'd be interested in it definitely. But am interested in the brain in a technical way, rather than an emotional way. I think it's a fantastic computational device that needs to be decoded. It's so special and I believe that in my lifetime we will have developed many drugs that can agonise selectively. That's our main drawback currently. Selective drugs are few and far between and are often ineffective. Blood brain barrier implications can change all drugs as well.
I'm immensely interested in the subject but I'm obviously not always correct. So little is known about the brain for sure.
Well I took a psych course and towards the end of the semester we had started to learn about the chemical aspect of the brain and the effects of certain drugs on it. Psych isn't all emotional stuff, but once you get past the elementary stuff you do start to go more in depth into the question of how our brains work and why it does this or that. None the less it is something you should look into sometime later in your life.
I read a lot about the subject and there is a chemical aspect to the brain but it's a very small component of it. The important factor to grasp is the varying densities of receptor subtypes in our brain. It is only relatively recently it was discovered that there are neurotransmitters in our brain. Previously it was thought that there was just an electrical signalling for different feelings.
Drugs absolutely cannot solve long-term depression in the brain. You have to withdraw from those antidepressants at some point and serotonin's involvement in depression is a controversial subject. Many people believe, as I've said earlier, that depression is due to EXCESS serotonin rather than a lack of serotonin.
SSRIs help because their ultimate outcome is downregulation of serotonin receptors. Serotonin is not a happy chemical as some people think. Dopamine is the euphoric neurotransmitter and I believe dopamine is the key to treating depression.
Serotonin regulates mood, relaxation and sleep (amongst other things) but because there are a vast amount of serotonin subtypes that are individually variant, we cannot possibly give a drug to everybody to help them. If my 5-HT2c receptor density is high, for example, I will most likely feel anxious all the time and be more susceptible to psychotic episodes however a high 5-HT2a receptor density will neutralise this issue.
The future of neuroscience is in finding selective agonists for all receptor subtypes and making drug cocktails tailored to individual patient requirement. Because different receptors downregulate/upregulate at different paces, the treatment would be effective for a very short time. People have to accept that depression is almost always pathological and there's not really a way to cure it except through lifestyle.
i don't think dopamine is the euphoric transmitter hook line and sinker (i say this because schizophrenia is thought to be caused by an over abundance of dopamine or some shit like that, and drugs like levo dopa which increase dopamine in the brain's side effects are far from euphoric). i don't even think any of the main neurotransmitters are really that simple either. i guess it all depends on where it's released or something
even if what i just said is all wrong you are right about medications. they're only a band aid. plus i just got off one of my heavier medications and even though im much more manic and less self aware of my needs, like i haven't eaten much or slept much since i got off it, and went a week without spanking it [sp](just solved that problem and feel a bit better)[/sp], i feel very much better, especially after toughing out that rough patch (completely sober btw... not entirely how i would have wanted to do it :(. )
honestly this kind of shit really pisses me off because the first couple days i got off of that med i felt fantastic and then things went downhill from there. it leads me to believe the pharma companies know about shit like this and depend upon it to sell more medication cause a person would go right back on it without toughing out that bad period after getting off. another thing that pisses me off is the pharma companies complete lack of interest in the negative side effects of anti psychotics (akathisia, look it up, it's like being trapped in your body and makes you want to smash your head against something solid)
Dopamine is DEFINITELY the euphoric neurotransmitter. Dextrodopamine would cause euphoria in theory but AFAIK this does not exist on the market. Levodopamine just facilitates peripheral effects. L-DOPA does not have central activity. L-DOPA exists primarily for parkinsons patients.
I have no doubt in my mind that dopamine is the euphoric transmitter. Serotonin is really not euphoric at all. It's calming and serotonin regulates your mood, but it does not cause euphoria.
I've experienced akathisia when I was on Sertraline and I agree it is horrible.
Alright, thank for the info.
One more thing, tommorow i will party hard, there will be a lot of drink.
I was wondering if it could help if i dont take my medication this morning.
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