Researchers at Gladstone Institutes in San Francisco report that a gene variant associated with Alzheimer’s works differently in mice and humans, and they also demonstrate how modifying this gene could potentially prevent the plaques associated with Alzheimer’s from forming and damaging the brain.
An ApoE3 gene variant is associated with Alzheimers disease
The gene apolipoprotein E3 ApoE3 has a variant known as ApoE4, which is associated with the development and progress of Alzheimer’s disease. People with just one copy of the ApoE4 gene are at twice the risk as people without this gene variant. Some people even have two copies of the ApoE4 gene, which makes their risk of Alzheimer’s a staggering twelve times greater.
Both the ApoE genes produce their own forms of ApoE protein, which differ in structure. The ApoE4 protein is fragile and fragments because it cannot function in the same way as the regular ApoE3 protein in human nerve cells. These fragmented protein pieces are associated with the increased production of amyloid-β peptides and tau phosphorylation that are typical of Alzheimer’s disease.
The researchers wanted to find out how ApoE4 is linked to Alzheimer’s disease. They considered the possibility that the increased amyloid-β and tau phosphorylation from the fragmentation of ApoE4 drives disease progression. Another possibility involved the negative consequences of a lack of ApoE3 proteins, as they were replaced by the ApoE4 variant. The team also considered a combination of both of these possibilities.
https://www.leafscience.org/alzheimers-reversed-by-editing-a-single-gene/
This forum needs more good vibes. It took away my grandpa, and I am looking forward to the day humanity cures it.
reverses in the sense that it can greatly reduce your chances of getting it, the damage from this horrible disease is well, literally brain rot.
I have a strong feeling my dad is developing Alzheimers, all the signs and symptoms are there
It's just a matter of getting the stubborn prick checked out
Drag him if you have to, it's better find out early.
do it sooner rather than later, even if he hates you, there are medicines to slow it
Very Good, This one step to make Genetic editing more acceptable for most countries.
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