A New Cancer Vaccine Shown to Be 100% Effective in Mice With Aggressive Melanoma - Sensationalist Headlines

https://www.sciencealert.com/new-melanoma-cancer-vaccine-combo-is-100-effective-in-mice Must be a real good time to be a mouse

great for mice with this very specific form of cancer

mice and people are similar enough that these kinds of studies help but you really don’t see a single mouse study translate into similar results in humans as of yet. Its progress but nothing conclusive yet

Do people pay you folks for making naysaying posts like this?

any progress and semblance of hope in this field is important. I have lost many family members to cancer, my closest friend ( who is my age, 25 ) has been fighting cancer since he was 4 years old. this naysaying is tired. your pessimism/nihilism serves no purpose.

There is as I understand it very genuine reasons to be skeptical of studies done on mice though.

so do you even know how cancer immunotherapy works or not

Melanoma is one of the most deadly forms of cancer, this is a huge leap

this is great news but keep in mind, the last time this happened they went to human trials and it somehow almost killed basically everyone because of some peculiarity of the human immune system

I've never heard anything like that happening, I keep a close eye on cancer since I'm prime for skin cancer any time now.

You're right, let's just drop all this dumb research stuff!

You may be talking about the deaths in Juno's CAR-T trials. CAR-T is a different type of cancer immunotherapy that introduces engineered T cells into the patient, whereas the technique here involves activation of a tumour-specific immune response potentiated by a newly discovered adjuvant (a TLR ligand). There's definitely potential for severe adverse reactions but the risks are not directly comparable.

Man, I can't believe I live in a time where we might just see the end of cancer.

The data will be useful but a lot mouse to human trials just seem to show they're ineffective due to the tiny yet important differences.

not sure why this is dumbed. a very large number of trials that work great on animals fail miserably on humans. I am not denouncing progress, however its better to wait for human trial results before getting too hyped

It's getting dumbed because it's a pointless snipe. Granted the article isn't great and doesn't really summarise the key discovery here, which is that the efficacy of inducing an immune response to the cancer cells can be boosted using an adjuvant. Unfortunately attention-grabbing terms like "new cancer vaccine" look pretty and get lots of ad revenue, but are largely misleading.

Cool, progress. Nothing usable as yet but this is the kind of thing that eventually leads to breakthroughs we can apply to people.

If studies done on mice were meaningless no one would study mice my dude.

From what I understand mice are suboptimal testing animals but are used anyway because they are cheap, have short generations, are small, easy to keep in a lab setting, and can be easily genetically modified, compared to other animals. Animals that would be better for testing on are more expensive and also almost universally illegal to test on. Mice aren't covered under the animal welfare act. From what I understand an overwhelming amount of trials done with mice end up with the results not applying to humans at all. I could be wrong and I'm not super informed on it but that's how I understand it

Imagine aliens coming to earth and seeing us conducting these experiments on mice. I bet if they see these articles they'd think the mice rule over us with us coming up with cures to any ailment they seem to have. With the cures eventually working it's way down to us like trickle-down miceconomics.