• China’s CRISPR twins might have had their brains inadvertently enhanced
    26 replies, posted
https://www.technologyreview.com/s/612997/the-crispr-twins-had-their-brains-altered/
https://files.catbox.moe/uu1ozz.jpg
Neuromods...
Worth noting is that the guys who did this research don't necessarily view it as a positive thing since it's impossible to predict just how this could have affected them. “The answer is likely yes, it did affect their brains,” says Alcino J. Silva, a neurobiologist at the University of California, Los Angeles, whose lab uncovered a major new role for the CCR5 gene in memory and the brain’s ability to form new connections.  “The simplest interpretation is that those mutations will probably have an impact on cognitive function in the twins,” says Silva. He says the exact effect on the girls’ cognition is impossible to predict, and “that is why it should not be done.”
"Inadvertently" I guarantee they're trying to create super humans with their tests and it was on purpose.
If they accidentally made super humans with no side effects, then hell yeah sign me and my kids up. This is some good testing even if it is a little ethically confusing. We literally have the power to just edit our genes to include the enzyme to fight HIV. Include copies of the TP53 gene and bam we got cancer prevention too please.
I will not envy these two. Their life is likely going to be under constant scrutiny with little regard to how they feel about it.
Double that, having the whole world and scientific community breathing on your necks 24/7 is going to be detrimental to their mental health whilst growing up.
That's not how it works, yeah they're super human, then their offspring is born with leisions and tumors after that. These kinds of mutations are incredibly cancerous.
what happens when we lose track of them and they bring those mutations into society O_o
yeah they might poison the water supply with their brain juice and make the entire next generation of children autistic it'll breathe new life into this site's membership count
Amazing, so they supposedly tried to make humanity resistant to HIV but ended up initating events that might lead to Elfenlied.
Right now it is all speculation. They need to wait for the children to grow up in order to see how advanced they really are. Also, there are already people in the population that are like this. It isn't the presence of a gene, but the absence of it which causes this effect.
Silva says because of his research, he sometimes interacts with figures in Silicon Valley and elsewhere who have, in his opinion, an unhealthy interest in designer babies with better brains. That’s why, when the birth of the twins became public on November 25, Silva says he immediately wondered if it had been an attempt at this kind of alteration. “I suddenly realized—Oh, holy shit, they are really serious about this bullshit,” says Silva. “My reaction was visceral repulsion and sadness.” Can these rich fucks just stop.
Irresponsible and immoral experiments like this are nonetheless a great way to see "what would happen if..." Can't wait to hear about this again in a while.
what, they vaccinate people just by being near them? like that kid in X-Men that supressed the mutant gene?
https://www.youtube.com/watch?v=wRnSnfiUI54
As I've repeatedly said, the people in Silicon Valley are so far up their own ass that they'd rather automate the rest of the world out of existence. In their minds we're only good for money and data to create better automated systems. Once both of those goals are completed they'd rather let us starve and die. For Christ's Sake, Google's old head of the AI division legitimately set up a cult to worship AI and considers anyone who goes against Automation and AI to be a racist. Silicon Valley needs to burn. They're the next generation of rich assholes who will fuck over the planet and HUmanity just like the currently dying Koch Brothers, Oil and Coal Barons and old Bank CEOs. Outside of people like Elon Musk, who for all his stupid shit, I truly believes wants to make the world better for humanity in general.
Just make any potential super human infertile.
But even that could go horrifically wrong, which is why we're actually testing that kind of idea on a very closed off and untouched island full of mosquitoes.
I mean if they can't pass on their genes what's the worst that could happen?
It could create a new virus, it could fail and actually bring on a nasty mutation that will take generations to remove.
Sorry I didn't mean to imply that these children right now are all that is needed to ensure no side effects. If there was no side effects including reproduction, or any other thing that I didn't explicitly mention. Then sign me and my kids up.
everyone's laughing now, but really this is just china preparing for the third world war by eventually creating super soldiers. one step at a time...
I highly doubt you will live long enough to find out because the first time we do it will taken literal generations for us to have any proper information about the positive or negatives.
After a rigorous research of like 10 lines of wikipedia about the gene they CRISPR'd away, I'm actually partial to their story that they really just wanted to see about curing HIV, and some partial resistance to strokes and dementia and such is just a possible side effect. https://en.wikipedia.org/wiki/CCR5 In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited the Delta 32 mutation resulting in the genetic deletion of a portion of the CCR5 gene. Homozygous carriers of this mutation are resistant to M-tropic strains of HIV-1 infection. Increased levels of CCR5 are part of the inflammatory response to stroke. Blocking CCR5 with Maraviroc (a drug approved for HIV) may enhance recovery after stroke.[32][33] In the developing brain, chemokines such as CCR5 influence neuronal migration and connection. After stroke, they seem to decrease the number of connection sites on neurons near the damage.[32] Disabling CCR5 reduces cognitive decline and dementia associated with several neurodegenerative diseases, including HIV.[34] It makes sense that CCR5 is the first thing they they targeted, since it's a major lead on why one of the only two people who were apparently cured of HIV was apparently cured of HIV. https://en.wikipedia.org/wiki/The_Berlin_Patient Also: They only tried to disable CCR5 in the babies, but didn't manage to. So don't expect them to grow into HIV-resistant lex luthors or anything (which probably wouldn't be the case even if they succeeded, HIV and intelligence are about more than just one protein).
But why HIV-resistance and not a fatal defect? How are you going to test if it worked as intended? Try to deliberately infect them with the virus? Or was he going to gene-edit thousands of babies and then see, after decades, if they had a statistically lowered risk of HIV-infection?
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