• Thinking about trying weed.
    81 replies, posted
I take anti-depressants and I'm fine. Then again I only smoke once every 1-2 weeks.
[QUOTE=xxFoxxx;21883103]1. It can. Smoking while you're taking anti-depressants can cause serotonin syndome. I officially recommend you [B]not[/B] smoke weed.[/QUOTE] this is complete shit my friend. cannabis doesn't interact with any other drugs to cause ss.
anti-depressants are known to interact with almost every drug that is psychoactive. Weed is no different. But possibilities for SS are quite small. I don't think it would ever happen with weed.
yeah, they may be known to interact with almost every drug, but that doesn't mean that there's a chance of SS with almost every drug. i'm still pretty certain it'll be impossible to achieve serotonin toxology.
[QUOTE=xxFoxxx;21883103]1. It can. Smoking while you're taking anti-depressants can cause serotonin syndome. I officially recommend you [B]not[/B] smoke weed.[/QUOTE] Dude, I'm on anti-depressants. All they do is make the weed better.
[QUOTE=catch33;21879584]Ummm.. marijuana being a depressant means that it slows down the body, not that it makes you sad lol.[/QUOTE] Marijuana isn't a depressant. Depressants suppress breathing, the gag reflex and cause temporary ataxia, much like alcohol and opiates. Marijuana does none of these things, which is why it's so safe. [editline]03:44PM[/editline] [QUOTE=xxFoxxx;21883103]1. It can. Smoking while you're taking anti-depressants can cause serotonin syndome. I officially recommend you [B]not[/B] smoke weed. [/QUOTE] THE FUCK ARE YOU TALKING ABOUT?! Serotonin Syndrome is caused when you mix too many SSRIs or SRAs. Weed does not release Serotonin, weed does not inhibit the reuptake of Serotonin.
Actually, google is telling me that xxFoxxx is right. Oh well, I'll keep doing it, and I'll keep loving the shit out of it. Yeah, it makes the marijuana more intense, but that's what I'm looking for
I don't see how Marijuana, something that agonises CB1 and CB2 receptors, can cause Serotonin Syndrome. Does Cannabis suddenly release Serotonin now? Just to say. This means you can't smoke weed with Tramadol, with MDMA (even worse than an SSRI for SS), DXM etc. You're SERIOUSLY telling me you'd never mix weed with MDMA because of SS? Are you insane?
When you take MDMA it's like a one night thing... Anti-Depressants are a daily thing for months or even years. I already said that I smoked weed while I was on anti-depressants and acknowledged that the chances were miniscule. However, this guy is here for information, and while the chances are slim, it's still a possibility that I think he should be aware of.
[QUOTE=Dan The Man;21899685]I don't see how Marijuana, something that agonises CB1 and CB2 receptors, can cause Serotonin Syndrome. Does Cannabis suddenly release Serotonin now? Just to say. This means you can't smoke weed with Tramadol, with MDMA (even worse than an SSRI for SS), DXM etc. You're SERIOUSLY telling me you'd never mix weed with MDMA because of SS? Are you insane?[/QUOTE] MJ does cause the release of seratonin. It's why you laugh so much, why you're happy for so long, and why some people get that depressed feeling after their high so they want to smoke again. Makes sense that it would cause SS.
It's Ser[b]o[/b]tonin. I find it ridiculous, even if weed DOES release Serotonin, that it could cause SS. Countless people smoke weed and take Tramadol. I've never heard of SS resulting from that. [editline]06:27PM[/editline] [QUOTE=xxFoxxx;21900830]When you take MDMA it's like a one night thing... Anti-Depressants are a daily thing for months or even years. I already said that I smoked weed while I was on anti-depressants and acknowledged that the chances were miniscule. However, this guy is here for information, and while the chances are slim, it's still a possibility that I think he should be aware of.[/QUOTE] So you're saying the chances are slim that he'll get SS, so he should [b]not[/b] smoke. Which is pretty much what your words were. You're more likely to be hit by an asteroid.
[QUOTE=Dan The Man;21901099]So you're saying the chances are slim that he'll get SS, so he should [B]not[/B] smoke. Which is pretty much what your words were.[/QUOTE] No. That's actually exactly what I said. If after reviewing the dangers he still believes that he still wants to try, that would be his decision. If by some astronomically small chance he gets SS, that would be his fault and not mine.
i still maintain it's not serotonergic whatsoever.
Then you maintain a fallacy, sir.
i'd love some proof though. i haven't been insulting at all here, i've just always thought that it isn't serotonergic at all, and i'm not sure what source you both are getting that it is from.
[quote]The active ingredient of cannabis is ∆9-tetrahydrocannabinol (∆9-THC) and it is thought to exert its effect by binding to cannabinoid CB1 receptors on pre-synaptic nerve terminals in the brain. ∆9-THC binding to CB1 receptors activates G-proteins that activate/inhibit a number of signal transduction pathways. The G-proteins directly inhibit N and P/Q-type voltage dependant calcium channels and sodium channels and indirectly inhibit A-type calcium channels via inhibition of adenylate cyclase. ∆9-THC binding and G-protein activation also activates inwardly rectifying potassium channels and the MAP kinase signalling pathway. The cumulative effect of these pathways is the euphoric feelings associated with cannabis use.[/quote] [url]http://www.cnsforum.com/imagebank/item/MOA_cannab/default.aspx[/url] [editline]07:28PM[/editline] Oooh. Found even more. [url]http://www.bluelight.ru/vb/showthread.php?t=451611[/url] Apparently Cannabis actually INHIBITS a Serotonergic receptor, perhaps explaining the anti-emesis it invokes. EDIT: Anyway guys, Meader, Fox, please stop spouting rubbish about weed and Serotonin. It appears there is a tiny link between them which is contradicted all over the web. The only proper study I could find suggested it increases Serotonin levels slightly at low doses, and decreases levels at high doses, but these changes are so minute that they could not possibly be related to the effects and could not be harmful.
[QUOTE=soccerskyman;21871020]Well, I am curious to what dangers I should be aware of and I have a few questions. 1. I take anti-depressants. Dose this cause an issue? 2. How long do highs last? 3. Could this affect my schoolwork? 4. How much dose weed usually cost? (standard quality) 5. What age is appropriate for starting? Discuss.[/QUOTE] 1: Weed doesn't conflict with any other drugs. 2: depending on the quality of the weed. 'Danks', which means high quality marijuana, can get you high all day if your tolerance is low. I pay a bit less than 20 a gram for danks, but i'm in minnesota, so good weed is kind of scarce. if you live on the coast or in a populated area it may be considerably less. JUST DONT SMOKE MIDS, thats weed with seeds in it. DONT DO IT. DONT DO IT DONT DO IT DONT DO IT. If you get weed that is 'bricked', as in pressed into squares that are almost like plywood, there is a really good chance that its bad weed. Mids may get you a little high if you've never smoked before, but its basically a placebo since there is very little thc in those particular plants. 3: definately if you make a habit of it. Take my word for it, coming from someone who has literally spent thousands of dollars on this habit from high school onward, marijuana is a drug that can put you in a stupor if you smoke too often. Maybe once every week or 2 weeks if you want to keep it a 'special' feeling. I made the mistake of smoking once a day for a very long time, and looking back on it, its a fucking waste. You don't get nearly as high, its incredibly expensive, and you just feel tired and dumb. 4: 'standard' quality weed is relative on the location. Go for the highest quality you can get, ask for DANKS. google image pictures of 'dank weed' and you will see what good weed is supposed to look like. As I said, a little less than 20 dollars a gram for top quality bud is a fair price in areas that have scarcity. 5: I'd say probably 16 or older. Remember the shit you are dealing with here: drugs change the way you perceive everything. You don't want to fuck up your brain if it's still developing, so... yeah, i'd say at least 16. Just a word of warning: A lot of people discredit the 'gateway drug' theory, but there is a bit of truth, in that the people you buy weed from will probably also sell other drugs, and you may feel the urge to experiment. HEED THIS ADVICE: IF ITS SYNTHETIC, STAY THE FUCK AWAY. I've seen too many of my friends become retarded from doing bad e all the time. if you are going to do drugs, stick with weed: it grows naturally out of the ground, so you know exactly what you get when you buy it, and NOONE EVER DIED FROM SMOKING POT. EVER. as far as drugs go, weed is VERY safe. Heed this old stoner's advice and you will go far.
[QUOTE=treetopflyer;21902652]HEED THIS ADVICE: IF ITS SYNTHETIC, STAY THE FUCK AWAY.[/QUOTE] go fuck yourself.
[QUOTE=Dan The Man;21902067] Anyway guys, Meader, Fox, please stop spouting rubbish about weed and Serotonin. It appears there is a tiny link between them which is contradicted all over the web. The only proper study I could find suggested it increases Serotonin levels slightly at low doses, and decreases levels at high doses, but these changes are so minute that they could not possibly be related to the effects and could not be harmful.[/QUOTE] You make me laugh. I'm not spouting rubbish, I'm stating what I know of as fact. I am always welcome to having my views overturned by fact, so don't assume I'm going to be a little bitch about things. That's how needless fights start.
Provide evidence for Serotonin syndrome being caused by weed please. If you wish to continue this argument. Meader, I like you, I respect you, this is purely a technical debate, it's not personal.
[QUOTE=Dan The Man;21903472]Provide evidence for Serotonin syndrome being caused by weed please. If you wish to continue this argument. Meader, I like you, I respect you, this is purely a technical debate, it's not personal.[/QUOTE] I surely wasn't taking it personally until it felt like a direct attack. And I will search for some evidence as well, I agree I should be able to back up my part of the argument.
I've provided two articles indicating that Marijuana works almost completely by agonism of CB1 and CB2 receptors. It does not have significant action on Serotonin.
My understanding is that marijuana increases Serotonin and Dopamine levels in the brain. Serotonin is responsible for the relaxation and hunger. Dopamine is what puts the goofy smile on your face and makes everything funny. Dopamine is also responsible for the paranoia and delusional thought This is just what I have learned in my psychology classes. I've never seen anything that suggested otherwise, though I have not done a whole lot of research on marijuana's effect on neurotransmitters. I do not, however, believe that it could cause Serotonin Syndrome. That seems ridiculous. Marijuana increases Serotonin levels, but does not flood the brain with serotonin or block the reuptake of serotonin (which, unless I am mistaken, is what MDMA does)
What do you think CB1 and 2 do? [url]http://www.ncbi.nlm.nih.gov/pubmed/10454705[/url] [editline]03:24PM[/editline] CONCLUSION: The results show that cannabinoid receptors are expressed in human placenta and BeWo cells and play a role in the regulation of the serotonin transporter activity.
[quote]Serotonin syndrome is a rare but potentially deadly condition that results from the combination of two or more serotonin-boosting drugs.[/quote] [url]http://stanford.wellsphere.com/drug-addiction-article/serotonin-syndrome/941088[/url] [quote]The effects of marijuana start as soon as 1-10 minutes after it is taken and can last 3 to 4 hours or even longer. Experiments have shown that THC can affect two neurotransmitters: norepinephrine and dopamine. Serotonin and GABA levels may also be altered.[/quote][url]http://faculty.washington.edu/chudler/mari.html[/url] That's just a small sample of what I've found from the research. For the most part, I've discovered that nobody is really sure if serotonin levels are effected, but most agree if they ARE, it's in-advertly. So in reality, it COULD cause SS, but really it won't unless you smoke mad amounts. So I do not retract my comment, but rather amend it. The possibility is there, but it is rather unlikely. It is a personal judgment call from here.
"They play a role in the regulation of the serotonin transporter activity" != It's an SSRI or an SRA. The argument is not whether Cannabis affects neurotransmitters at all. It's if it affects them significantly. I've NEVER heard of Cannabis causing Serotonin Syndrome. Can you provide a case study? Also, the hunger is caused by CB1 agonism, eating food will kill a Marijuana high because CB1 is there to cause us to want to eat. Excess Dopamine suppresses appetite, not increase it. I have no idea about the effects Serotonin has on appetite. To be honest, the conclusion I've come to is that if you are on anti depressants (I am too btw, Zoloft), you can smoke weed with no worries about SS. Do you agree or not? [editline]09:29PM[/editline] Oh my, you're so pedantic about it. It's saying it [b]may[/b] "alter" Serotonin levels. Firstly, it doesn't say if it increases or decreases. It also doesn't even state a fact. That's not a cite-worthy source. Whatever, I give up. Fine, don't smoke weed and be worried about a ridiculous condition that you won't get.
Unrelated: How long have you been on Zoloft? How much are you taking? I switched to Budeprion SR (Wellbutrin) recently. It's... fucking weird...
[QUOTE=Dan The Man;21904917]"They play a role in the regulation of the serotonin transporter activity" != It's an SSRI or an SRA. The argument is not whether Cannabis affects neurotransmitters at all. It's if it affects them significantly. I've NEVER heard of Cannabis causing Serotonin Syndrome. Can you provide a case study? Also, the hunger is caused by CB1 agonism, eating food will kill a Marijuana high because CB1 is there to cause us to want to eat. Excess Dopamine suppresses appetite, not increase it. I have no idea about the effects Serotonin has on appetite. To be honest, the conclusion I've come to is that if you are on anti depressants (I am too btw, Zoloft), you can smoke weed with no worries about SS. Do you agree or not? [editline]09:29PM[/editline] Oh my, you're so pedantic about it. It's saying it [B]may[/B] "alter" Serotonin levels. Firstly, it doesn't say if it increases or decreases. It also doesn't even state a fact. That's not a cite-worthy source. Whatever, I give up. Fine, don't smoke weed and be worried about a ridiculous condition that you won't get.[/QUOTE] You seem to be pretty upset about this. a ".edu" isn't cite-worthy? Please explain what is then, because I'm completely lost. I thought .edu and .gov and sometimes .org were always considered trustworthy... [url]http://www.usatoday.com/news/health/spotlight/2001-01-24-tyson.htm[/url] There's a specific case they looked at, and some general info about Zoloft specifically interacting with pot [quote] [B]Interactions[/B] According to Nahas' [I]Marijuana and Medicine[/I], these are some of the possible interactions between marijuana and various anti-depressants: [IMG]http://images.usatoday.com/news/health/spotlight/rarrow.gif[/IMG]Tricyclics — "Additive tachycardia, " or accelerated heartbeat, hypertension, and drowsiness. Transient delirium and cognitive problems were also observed in four children. [IMG]http://images.usatoday.com/news/health/spotlight/rarrow.gif[/IMG]SSRIs — "(One) case report of severe mania with psychosis on fluoxetene (Luvox) shortly after smoking marijuana. THC may inhibit serotonin uptake and increase its synthesis," says the text.[/quote]
[QUOTE=Meader;21900843]MJ does cause the release of seratonin. It's why you laugh so much, why you're happy for so long, and why some people get that depressed feeling after their high so they want to smoke again. Makes sense that it would cause SS.[/QUOTE] But this would mean that cannabis can be physically addicting, which it ISN'T. Yes it CAN be psychologically addicting, but SS is typical of physical addiction.
Easy with the .gov, buddy Remember, they're the ones that told us marijuana kills brain cells
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