• Drugs Discussion Questions Thread V "how many weed needles is too many?"
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[QUOTE=yawmwen;43182133]how does opiate use create physical dependency? i sorta assume that long term opiate use causes your brain to produce less endorphins because it sorta doesn't have to since you have an alternative source of other chemicals that bind to opiate receptors in the brain. i guess this question extends to all drugs that cause dependency. why do benzos, alcohol, and barbituates cause physical dependency?[/QUOTE] Benzos and Alcohol have the same action for physical dependency; they both work on your GABA receptors and you'll get the good ol' DTs on Benzo withdrawal just like Alcohol. Benzo withdrawal will outright kill you if you're deep enough, just like booze. Opiates, cocaine, all these other drugs have different actions for dependency so asking how they keep you addicted you'd have to go over each one because they do their own thing to the brain.
[QUOTE=Lebowski;43182389]Benzos and Alcohol have the same action for physical dependency; they both work on your GABA receptors and you'll get the good ol' DTs on Benzo withdrawal just like Alcohol. Benzo withdrawal will outright kill you if you're deep enough, just like booze. Opiates, cocaine, all these other drugs have different actions for dependency so asking how they keep you addicted you'd have to go over each one because they do their own thing to the brain.[/QUOTE] well cocaine doesn't create physical dependency. this is how i [i]assume[/i] dependency works: cocaine, meth, crack, and other psychostimulants tend to be "dopamine re-uptake inhibitors". their mechanism involves [i]enhancing[/i] the effects of natural dopamine release in the brain by disabling transporters involved in reuptake. the chemical doesn't replace dopamine and your brain doesn't adapt to dri use by producing less dopamine. these chemicals are psychologically addictive, but they don't create a physical dependence. this is, of course, ignoring neurotoxicity of high dopamine levels and that the synapses of neurons eventually get damaged to the point that dopamine becomes less effective, but that's a different story. on the other hand, an opiate like morphine(or the chemicals it metabolizes into) actually bind to opiate receptors in the brain to produce the euphoria/analgesia associated with endorphins. it doesn't enhance the endorphin release, it replaces it. over time the brain adapts to the presence of these consumed chemicals and stops naturally producing as much endorphins on its own(it doesn't need to, so why bother?). so when you actually stop using opiates, your body doesn't have the endorphins available to take over the functions that endorphins are required for so you get those detox symptoms like high pain, nausea, etc. the question i have is how rooted in truth is this? do these drugs cause dependency because they replace natural brain functions and the brain sorta adapts and stops doing things on its own? a quick wikipedia search states that the metabolites of ethanol don't replace gaba, they enhance it. but it also states that in increases activity in gaba receptors so maybe it also binds or something. all i know is that cocaine does not form physical dependency but opiates do and that cocaine only enhances the neurotransmitter while opiates actually bind to neurotransmitter receptors. so i assume that difference is the difference that creates dependency.
[QUOTE=yawmwen;43182696]well cocaine doesn't create physical dependency. this is how i [i]assume[/i] dependency works: cocaine, meth, crack, and other psychostimulants tend to be "dopamine re-uptake inhibitors". their mechanism involves [i]enhancing[/i] the effects of natural dopamine release in the brain by disabling transporters involved in reuptake. the chemical doesn't replace dopamine and your brain doesn't adapt to dri use by producing less dopamine. these chemicals are psychologically addictive, but they don't create a physical dependence. this is, of course, ignoring neurotoxicity of high dopamine levels and that the synapses of neurons eventually get damaged to the point that dopamine becomes less effective, but that's a different story. on the other hand, an opiate like morphine(or the chemicals it metabolizes into) actually bind to opiate receptors in the brain to produce the euphoria/analgesia associated with endorphins. it doesn't enhance the endorphin release, it replaces it. over time the brain adapts to the presence of these consumed chemicals and stops naturally producing as much endorphins on its own(it doesn't need to, so why bother?). so when you actually stop using opiates, your body doesn't have the endorphins available to take over the functions that endorphins are required for so you get those detox symptoms like high pain, nausea, etc. the question i have is how rooted in truth is this? do these drugs cause dependency because they replace natural brain functions and the brain sorta adapts and stops doing things on its own? a quick wikipedia search states that the metabolites of ethanol don't replace gaba, they enhance it. but it also states that in increases activity in gaba receptors so maybe it also binds or something. all i know is that cocaine does not form physical dependency but opiates do and that cocaine only enhances the neurotransmitter while opiates actually bind to neurotransmitter receptors. so i assume that difference is the difference that creates dependency.[/QUOTE] I dunno though, personally I find the way cocaine gets you way more potent, despite the lack of withdrawal in comparison to opiates. Since cocaine actually [I]does[/I] start restructuring some pathways in your brain after the first couple times you use it, I can talk about opiates after having done them to the ridiculous degree I have without really wanting it; but mention cocaine and I'll practically jump outta my bloody seat. Any mention of the possibility of it and my bowels start moving instantly and I [B]have[/B] to take a shit. It's the weirdest thing. Talkin' about cocaine gets my heart pumping a little, there are studies that show in people who've done it enough their brain starts lighting up in a similar way as if they were actually on it when they simply talk about it. Hell, I can almost feel the smallest bit of a dopamine release going on up there at the moment just describing it. I dunno, physical dependency isn't the strongest aspect of dependency I might argue.
[QUOTE=Lebowski;43182814]I dunno though, personally I find the way cocaine gets you way more potent, despite the lack of withdrawal in comparison to opiates. Since cocaine actually [I]does[/I] start restructuring some pathways in your brain after the first couple times you use it, I can talk about opiates after having done them to the ridiculous degree I have without really wanting it; but mention cocaine and I'll practically jump outta my bloody seat. Any mention of the possibility of it and my bowels start moving instantly and I [B]have[/B] to take a shit. It's the weirdest thing. Talkin' about cocaine gets my heart pumping a little, there are studies that show in people who've done it enough their brain starts lighting up in a similar way as if they were actually on it when they simply talk about it. Hell, I can almost feel the smallest bit of a dopamine release going on up there at the moment just describing it. I dunno, physical dependency isn't the strongest aspect of dependency I might argue.[/QUOTE] I agree with that last line, psychological dependence has to be way worse, cause you're fighting your mind, not your body.
[QUOTE=Lebowski;43182814]I dunno though, personally I find the way cocaine gets you way more potent, despite the lack of withdrawal in comparison to opiates. Since cocaine actually [I]does[/I] start restructuring some pathways in your brain after the first couple times you use it, I can talk about opiates after having done them to the ridiculous degree I have without really wanting it; but mention cocaine and I'll practically jump outta my bloody seat. Any mention of the possibility of it and my bowels start moving instantly and I [B]have[/B] to take a shit. It's the weirdest thing. Talkin' about cocaine gets my heart pumping a little, there are studies that show in people who've done it enough their brain starts lighting up in a similar way as if they were actually on it when they simply talk about it. Hell, I can almost feel the smallest bit of a dopamine release going on up there at the moment just describing it.[/QUOTE] i feel you. i get chills and start sweating whenever i think about hitting the meth pickle. just thinking about taking a hit gives me those "dopamine chills" in the back of the neck. it's sorta like the feeling you get when you are cuddling or being caressed by someone you are romantically/sexually interested in. it's weird how just thinking about something so powerful can actually cause your brain to respond as if that chemical was present. [quote]I dunno, physical dependency isn't the strongest aspect of dependency I might argue.[/quote] physical dependency, from what i'v heard, is hell on earth while you are withdrawing. like people sweating and shaking and shitting for a week while in constant pain from opiates. i don't wanna compare the physical dependency to the psychological addiction because they are both miserable but different experiences. also some people try to use the term "psychologically addictive" as a way to downplay the addictive qualities of a substance. fuck that. being psychologically addicted to something like a psychostimulant is actually mentally scarring to a degree. post-acute withdrawal syndrome is a life-long thing(iirc); it only gradually gets better, never actually completely going away. no matter how hard you want to snap your fingers and forget about the substance, that substance has shaped your life to some degree and helped reshape your psychology. the effects of that addiction will last the rest of your life. it sounds incredibly dramatic, but you will "never be the same" again. not to say that it permanently makes your life shit, but it will influence you far into the future. i think some addiction therapists actually compare addiction with someone dying in terms of long-term psychological effect. like, when you quit the substance, you go through the "stages of mourning" to a degree. you have "lost" something that made your brain feel really good for a long time, you end up missing that experience, and that makes relapse easy. [editline]14th December 2013[/editline] [QUOTE=zach1193;43182941]I agree with that last line, psychological dependence has to be way worse, cause you're fighting your mind, not your body.[/QUOTE] idk that it's appropriate to say. i have never gone through detoxification from a chemical i was dependent on. i've seen my friend in tears having rapid consecutive panic attacks and heart palpitations from alcohol detox. i've heard of people writhing in pain for days from opiate detox. also it isn't an either/or situation. people coming off opiates or alcohol experience the physical dependency AND the psychological dependency. the detox is short term hell, but then they have to deal acute withdrawal syndrome for weeks or months, and then post-acute withdrawal syndrome after that.
[QUOTE=yawmwen;43182981]i feel you. i get chills and start sweating whenever i think about hitting the meth pickle. just thinking about taking a hit gives me those "dopamine chills" in the back of the neck. it's sorta like the feeling you get when you are cuddling or being caressed by someone you are romantically/sexually interested in. it's weird how just thinking about something so powerful can actually cause your brain to respond as if that chemical was present. physical dependency, from what i'v heard, is hell on earth while you are withdrawing. like people sweating and shaking and shitting for a week while in constant pain from opiates. i don't wanna compare the physical dependency to the psychological addiction because they are both miserable but different experiences. also some people try to use the term "psychologically addictive" as a way to downplay the addictive qualities of a substance. fuck that. being psychologically addicted to something like a psychostimulant is actually mentally scarring to a degree. post-acute withdrawal syndrome is a life-long thing(iirc); it only gradually gets better, never actually completely going away. no matter how hard you want to snap your fingers and forget about the substance, that substance has shaped your life to some degree and helped reshape your psychology. the effects of that addiction will last the rest of your life. it sounds incredibly dramatic, but you will "never be the same" again. not to say that it permanently makes your life shit, but it will influence you far into the future. i think some addiction therapists actually compare addiction with someone dying in terms of long-term psychological effect. like, when you quit the substance, you go through the "stages of mourning" to a degree. you have "lost" something that made your brain feel really good for a long time, you end up missing that experience, and that makes relapse easy. [editline]14th December 2013[/editline] idk that it's appropriate to say. i have never gone through detoxification from a chemical i was dependent on. i've seen my friend in tears having rapid consecutive panic attacks and heart palpitations from alcohol detox. i've heard of people writhing in pain for days from opiate detox. also it isn't an either/or situation. people coming off opiates or alcohol experience the physical dependency AND the psychological dependency. the detox is short term hell, but then they have to deal acute withdrawal syndrome for weeks or months, and then post-acute withdrawal syndrome after that.[/QUOTE] I've definitely gone through withdrawal HELL from Benzos and Opis, I've definitely had the shaky hands from benzos, and the pain radiating down my arms for days from opis; definitely the thing that's had the longest lasting effect was Cocaine though. Can NOT give you enough agrees for this post.
[QUOTE=zach1193;43182941]I agree with that last line, psychological dependence has to be way worse, cause you're fighting your mind, not your body.[/QUOTE] Well physical changes in the body affect the mind. They are very different things and I just don't think they can be compared like that in one being worse than another as they are both hell. [QUOTE=yawmwen;43182981] also some people try to use the term "psychologically addictive" as a way to downplay the addictive qualities of a substance. fuck that. being psychologically addicted to something like a psychostimulant is actually mentally scarring to a degree. post-acute withdrawal syndrome is a life-long thing(iirc); it only gradually gets better, never actually completely going away. no matter how hard you want to snap your fingers and forget about the substance, that substance has shaped your life to some degree and helped reshape your psychology. the effects of that addiction will last the rest of your life. it sounds incredibly dramatic, but you will "never be the same" again. not to say that it permanently makes your life shit, but it will influence you far into the future. i think some addiction therapists actually compare addiction with someone dying in terms of long-term psychological effect. like, when you quit the substance, you go through the "stages of mourning" to a degree. you have "lost" something that made your brain feel really good for a long time, you end up missing that experience, and that makes relapse easy. [/QUOTE] Post-acute withdrawal is not permanent though in some cases it may be but most people recover even if it takes them 10 years. I agree that you will never be the same though, the experience has changed who you are. [editline]14th December 2013[/editline] Or maybe they just feel normal after those many years because they are so used to the post-acute effects.
My sister came home from cali the other day, she decided to drop me off some brownies and cookies. I ate one and, it well it was the best high ive ever had. I ate one an hour ago and i feel fantastic. What do you guys think about edibles?
[QUOTE=TronCat;43184614]My sister came home from cali the other day, she decided to drop me off some brownies and cookies. I ate one and, it well it was the best high ive ever had. I ate one an hour ago and i feel fantastic. What do you guys think about edibles?[/QUOTE] I love edibles. This past summer I went on a cruise to Peurto Rico, St. Thomas, and another island that I can't recall the name of. I had just turned 18 and was kind of pissed that I couldn't buy alcohol on the ship, we were in international fucking water! Fuck you Carnival, all the other cruise lines let people drink at 18 once they leave the US. Anyways, I met some really cool kids on the ship, including these 2 brothers, who I became somewhat good friends with. On the second day, I heard a rumor from somebody that they had brought along quite a few weed cookies, so I politely approached them to buy 1. The older brother told me not to tell anybody else, but he was handing them out for free to his friends. What?!! I was amazed, giving away free weed cookies? That's the most generous thing ever. Me, my brother, and the 2 brothers were chilling in his room at about 2PM and I asked if I could check out the cookies, just to get a glance. He pulled out a bag of ~35 cookies and make a remark about the "other bag" being gone already. He said something along the lines of "I'd give you one now, but I'm sure you got shit to do later today", I told him I didn't, so he said alright and gave me a free cookie. Fuck yes! I was feeling high as a kite for 7 hours straight, and feeling good the rest of that long night. I think the other time he gave me a free cookie was on the 4th or 5th night, I took it 45 minutes before this magic show and nothing could have prepared me for what was going to happen. Right as the show started, the cookie hit me like a brick wall, I was laughing like a mother fucker. That's where it got weird. The magician was taking 15 volunteers, and, little did I know, my father was in the audience. I saw him climb up on stage with the others and turned to my brother: "Is that dad?!" From there the magician actually hypnotized most of the volunteers, obviously there were a few that left the stage because they weren't feeling it, but it was pretty mind-boggling. There were no sober nights on that cruise. Fun times.
it's normal for me to be supertired and unmotivated the day after mdma, right?
yes, try to eat some fruit and maybe score some 5-htp. also go for a run and you should start feeling better soon again
smoke some weed dude and do what scorpinat said take some 5 htp laughter is the best medicine, when i had this particular type of mxe it made me feel burnt out, i felt like screaming and crying one day. when i got like that i doing more didnt have any effect. one day i felt like that and then watched stand up, and felt so much better. then i did more mxe and got high from it. just relax and have a good day
i've just been sat in my room smoking all day, i enjoy this laziness
is it possible to get a medical license for a mental disorder
[QUOTE=The First 11'er;43192713]is it possible to get a medical license for a mental disorder[/QUOTE] Yes. Now be more specific, what state do you live in? What mental disorder?
[QUOTE=Ben Katz;43190626]laughter is the best medicine,[/QUOTE] I think ketamine is the best medicine Dxm comes close second though [i]god I love medicine[/i]
Be careful with Ketamine it causes bladder damage after prolonged use. You don't want to start pissin' blood :|
[QUOTE=SuperNatural;43192980]Yes. Now be more specific, what state do you live in? What mental disorder?[/QUOTE] WA, asking just in general what mental disorders as i was having an argument with someone
When chewing dried salvia leaves: should one rehydrate them before the chewing begins or does it make no difference ?
If gotten really high from hash milk several times, just put the milk and hash in a cooking pan and warm it until the hash is dissolved. It tastes disgusting but the high is totally worth it.
[QUOTE=Satansick;43200160]If gotten really high from hash milk several times, just put the milk and hash in a cooking pan and warm it until the hash is dissolved. It tastes disgusting but the high is totally worth it.[/QUOTE] i put a spoon full of butter in a casserole and melted it using very low heat. when it was melted i added the hash and mixed it together until it was a complete brown liquid. i then slowly added cream and chocolate milk while heating it up. it tasted pretty strongly of hash, but the chocolate also tasted through as well.
You said you weren't going to cook and then you make a hash infused feast.
haha i know :v: i live at home, so when i all of sudden had a chance to use the kitchen i hurried and just tried my best to make something i could stomach and get somewhat high off. it retrospect i could have added a little more hash, but the taste was actually really pleasant. i even woke up my little brother and gave him a little taste. he agreed that the taste was overall very nice.
Well it most certainly beats the filthy taste of hash milk.
Ok so I'm going to Amsterdam tomorrow and I'm a tit who doesn't speak any language other than English. Question 1: What is the word for dextromethorphan in German and/or Dutch? Or is it the same? Question 2: Where do I buy truffles in Amsterdam, what do they look like, and how much should I take (for a moderate trip (equivalent to an eighth of shrooms or 2 tabs of acid or something)). Also how much should I be expecting to pay?
[QUOTE=Satansick;43200388]Well it most certainly beats the filthy taste of hash milk.[/QUOTE] i can imagine. i think i'll make another batch if my mother leaves the house later.
[QUOTE=iwork3daysaweek;43200703]Ok so I'm going to Amsterdam tomorrow and I'm a tit who doesn't speak any language other than English. Question 1: What is the word for dextromethorphan in German and/or Dutch? Or is it the same? Question 2: Where do I buy truffles in Amsterdam, what do they look like, and how much should I take (for a moderate trip (equivalent to an eighth of shrooms or 2 tabs of acid or something)). Also how much should I be expecting to pay?[/QUOTE] dextromethorphan - I dunno why you would.. truffles.. - any shop that sells bongs/pipes etc... it's normally one box per person but i guess u can eat 2 boxes, and always haggle!
[QUOTE=iwork3daysaweek;43200703]Ok so I'm going to Amsterdam tomorrow and I'm a tit who doesn't speak any language other than English. Question 1: What is the word for dextromethorphan in German and/or Dutch? Or is it the same? Question 2: Where do I buy truffles in Amsterdam, what do they look like, and how much should I take (for a moderate trip (equivalent to an eighth of shrooms or 2 tabs of acid or something)). Also how much should I be expecting to pay?[/QUOTE] are you 17? then its gonna be hard for you to buy truffles or get in any coffeeshop... [editline]16th December 2013[/editline] especially because you are a ''tourist'' [editline]16th December 2013[/editline] probably 15 euro for 10 grams of truffles, the strength depends on the kind of truffles...
[QUOTE=scorpinat;43200767]are you 17? then its gonna be hard for you to buy truffles or get in any coffeeshop... [editline]16th December 2013[/editline] especially because you are a ''tourist''[/QUOTE] Unless you're with a big group of people or look really young you tend not to get asked for ID, well thats what I've found over the number of time I've been.
they will ALWAYS ask you for ID, especially after some fucking tourists killed themselfs on shrooms [editline]16th December 2013[/editline] strict rules are enforced by our government, if they get caught not asking for your ID they will be closed down within a month
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