• Drugs Discussion Questions Thread V "how many weed needles is too many?"
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[QUOTE=Toz;40008463]Think of the size of about a dime, but MDA. Posting pics now [editline]23rd March 2013[/editline] Also, what are some decent/cheap amphetamines that I could find in Canada? [editline]23rd March 2013[/editline] Could MDAs atomic weight be compared to say salt, and then compared by the size/amount ratio? [editline]23rd March 2013[/editline] Sorry for some shit pictures[/QUOTE] Why put white/yellow powder on white paper? Use a dark background for light colours. Well from what I can see that is not .5g of MDA, looks like maybe .2g so a single dose orally. You said you paid $20 and it was a total of $80 for an eighth? If 4 people pitched $20 each for 3.5g of MDA you should be getting .8g. [editline]23rd March 2013[/editline] Oh and salt cannot be compared to MDA. Where in Canada do you live? I live in BC, street Dexedrine(Dextro-amphetamine) caps go for $20 for 45mg(15mg caps) in Vancouver, that is a high price so I try to find people with Dexedrine scripts and pay maybe $10 for 40mg. Imo MDA is very stimulating I used to binge on it and use it instead of some d-amp. Nobody here can really suggest "decent/cheap amphetamines" because it depends on where you live and what is available to you from your dealers.
[QUOTE=Toz;40008463]Think of the size of about a dime, but MDA. Posting pics now [editline]23rd March 2013[/editline] Also, what are some decent/cheap amphetamines that I could find in Canada? [editline]23rd March 2013[/editline] Could MDAs atomic weight be compared to say salt, and then compared by the size/amount ratio? [editline]23rd March 2013[/editline] [IMG]http://i.imgur.com/DWrY2km.jpg[/IMG] [IMG]http://i.imgur.com/DWrY2km.jpg[/IMG] Sorry for some shit pictures[/QUOTE] Is that straight powder or is there some shards in it, otherwise that is def not .4 and maybe not even .2. Also you shoulda kept it in the bag, it's kinda easier to tell, well if you're used to seeing it in bags like I am.
[QUOTE=Memnoth;40002043]That doesn't seem likely, as the nature of synaptic receptor-tolerance seems to be loss of affinity due to the change in the electric charge pertinent to the ions connected to the overstimulated receptor causing it to no longer have the electric charge required to magnetically receive stimulation. It seems that NMDA-receptor antagonism reduces opiate addiction symptoms simply by being anesthetic as opiate-receptor stimulation revolves around the function of being pain-killing and separating your mind from your body renders the withdrawal symptom of pain mute. Therefore acting as a substitute where opiate-receptors can get more electrically receivable as dissociatives in general have a low property of stimulating them compared to pure opiates. At least that's my preliminary conclusion.[/QUOTE] A sensible conclusion though I am unsure if that is the full extent of opioid tolerance and the mechanisms of NMDA anti-opioid action as much about is yet unknown, and many anecdotal reports raise interesting points that go against your hypothesis. A Japanese study regarding the role of neuronal plasticity caused by NMDA and other non-opioid systems in opiate dependence: [QUOTE]Mechanisms for opioid tolerance and addiction are divided into two types of plasticity--cellular level and those occurring through multiple neuronal networks. Receptor desensitization through phosphorylation and endocytosis are currently well discussed using cell lines expressing opioid receptors in relation to acute tolerance mechanisms, while altered gene expression is mainly discussed in relation to the model mechanisms of chronic tolerance and dependence. However, little is known of mechanisms operating through plasticity of neuronal networks. In our approach, we began with the assumption that some non-opioid neurons with anti-opioid activity may cause neuronal plasticity, showing opioid adaptation and dependence. In mice lacking nociceptin/orphanin FQ receptor (NOP), or the NMDA receptor epsilon1 subunit, both of which mediate anti-opioid activities, analgesic tolerance and dependence following chronic morphine treatments were markedly attenuated. Chronic morphine-treatments increased NOP gene or epsilon1 subunit protein expression in the spinal cord or specific brain loci, respectively. Furthermore the rescue of the epsilon1 subunit gene in the specific brain locus of knockout mice recovers the tolerance and dependence. All these results suggest that the enhanced anti-opioid system may contribute to the development of morphine tolerance and dependence, and their contribution could be brain locus specific.[/QUOTE] And related: [QUOTE]The mechanisms underlying opioid tolerance are not fully understood, but appear to be comprised of two types of plasticity or counter-adaptation, at the cellular level and through neuronal circuits. Current studies mostly emphasize the cellular adaptation mechanisms, which include altered gene expression and receptor desensitization due to phosphorylation and endocytosis. However, the mechanisms underlying opioid tolerance and dependence are not always explained by cellular adaptation mechanisms alone. This review focuses on the plasticity in neuronal circuits achieved through an enhancement of so-called anti-opioid glutamate/NMDA receptor synaptic activities. There have been also conceptual advances in understanding the changes to supporting systems, which include the altered expression of key molecules regulating the anti-opioid system through neuron-glial networks.[/QUOTE] Another study where (+)-HA966 was found to potentiate morphine as well as reverse tolerance: [QUOTE]Using the C-fibre reflex as a nociceptive response elicited by a wide range of stimulus intensities in the rat, we recently reported that a single treatment with (+)-HA966, a glycine site-specific NMDA receptor antagonist: (1) potentiates morphine antinociception; and (2) reverses an established morphine tolerance. We presently aimed at determining whether our observation was likely to result from a direct effect on the spinal cord or an indirect effect of supraspinal origin. In a 2x2x2 experimental design, we compared the effects of 5 mg/kg morphine in: (1) sham-operated rats or animals whose brainstems had been transected at the level of the obex; (2) rats that were implanted with pellets, either 150 mg morphine or placebo; and (3) animals injected either with saline or 10 mg/kg (+)-HA966. The control C-fibre reflexes were similar in all groups of animals. As compared to "non-tolerant" rats, the depressive effect of morphine was weaker in "morphine-tolerant" animals where the threshold did not change following morphine but the gain of the stimulus-response curve decreased, albeit to a significantly lesser extent than in the "non-tolerant" group. Whether in "non-tolerant" or "tolerant" groups, the effects of morphine were stronger in "obex-transected" than in "sham-operated" animals. In all groups, the effects of morphine were potentiated by the preliminary administration of (+)-HA966. However, in the "morphine-tolerant" group, the preliminary administration of (+)-HA966 was more potent in the "sham-operated" than in the "obex-transected" groups. Since overall effects were very similar in "sham-operated" and "obex-transected" animals, we concluded for our model that the critical site for the expression of the neuronal plastic changes associated with morphine tolerance lies in the spinal cord.[/QUOTE] Reports from user LightCloud at Flashback stating that 3-HO-PCP does in fact have many opioid-like qualities with a great deal of euphoria: [QUOTE]Euforin som följde med denna var något av det bästa jag har upplevt. Tänk er att ni får en orgasm blandat med tramadol fast i en mer subtil form, då har ni välmåendet som denna gav. Tänk er dessutom att ni mår så bra ni kan, fast ännu bättre, då har ni hur ni mår psykiskt. ... Men glad som fan är jag! All musik är grym i alla fall. Känns som ett överglatt tramadolrus typ, utan den där sänkta känslan som opioider/opiater kan ge. ... Alltså euforin är helt galen. Jag hade kunnat ta detta istället för kodein, tramadol etc, då detta nästan slår dem bara att man inte blir lika sänkt och trött.[/QUOTE] And numerous general reports of NMDA-antagonists + opiate combination where it is always claimed the opiate effects did not grow weaker and were in some cases enhanced, something which doesn't make sense if a reduction of electric charge is the sole (or even main) reason for the tolerance-restrictive effect of NMDA-antagonism: [QUOTE]i take 30-45mg about 45 minutes to an hour before ingesting an opiate. and yes it works. i have been abusing opiates for about 2-3 months or so now and my tolerance has stayed at a pretty intermediate level. with dxm+weed 35mg of hydrocodone has me nodding pretty nicely.[/QUOTE] [QUOTE]I started using DXM in conjunction with opiate use about 6-7 months ago. I always use at least 45mg, but usually 60mg of DXM with every dose of opiate. It did not reverse tolerance, but it prevented tolerance from increasing. Before I started the DXM I to slowly increase dosage every month, but once I started the DXM, and even now, my dosage has remained identical and with even slightly stronger effect from the opiate dosage than 6 months ago(so I guess some reversal may have occured). Note: I also use a dose of 600mg of Tagament and 100mg of Diphendydramine with each opiate dose along with the DXM.[/QUOTE] [QUOTE]It's an NMDA antagonist so it reduced and prevents tolerance to opiates, and for some reason it increases the warmness, analgesia, and euphoria, for me atleast. That is at therapeutic doses. Anything above 90mg's will ruin an opiate high.[/QUOTE] [QUOTE]I'm also inferring from the study that the researchers must consider DXM safe taken long-term. I mean, assuming 80mg morphine qid, we're talking 320mg of DXM daily -- still quite a bit shy of the gram recommended above, but 320mg is (for most people) a very psychoactive dose. I'm only taking 15mg and definitely feel it helps. I can't explain my lack of Ultram tolerance after 400mg/day for several months any other way.[/QUOTE] Also of note for us amph users is that NMDA-antagonists seem to do even bigger miracles with stimulants by apparently reducing many side-effects like rapid pulse and vasoconstriction, potentiating the positive effects as well as effectively blocking tolerance-increase. [QUOTE]After hearing many glowing reports about how memantine inhibits the development of amphetamine tolerance, I started taking it at 5mg for 4 days, and have been on 10mg/day since. On the 12th day of being on 10mg memantine, I took my usual 15mg dose of amph, and felt a powerful surge of euphoria, sociability, confidence, and was completely free of SA. It was just like taking amphetamine for the first time! Over the next 4 days, I took 15mg each morning but skipped one day. Each dose was just as powerful and efficacious, AND the duration was extended to ~7-8 hours! So this brings me to today, where I decided to reduce my amph dose to 10mg, and it's working even better than 15mg did before starting memantine.[/QUOTE] [QUOTE]Memantine has truly saved my life, i do not exaggerate. Although Memantine, by itself, doesn't offer me significant benefits (other than reduction of OCD) it pretty much, is the most important part of my regimen. It doesnt seem possible to actually prevent the tolerance to the Actual beneficial effects of Amphetamine, but....it is possible. I see no benefit in taking Amphetamine at all, if not combined with Memantine. I currently take 15 mg Memantine a day......5 and 10mg/day both significantly inhibited tolerance, however, only for a period of 2-4 weeks, I could take Amphetamine consistently (every day, 30mg) with its mood-elevating and anxiety-reducing and pro-social benefits, continuing to remain and be of use. When tolerance becomes a problem, i take short 2-5 day breaks from Amphetamine, and every time, my tolerance goes down significantly, and I am able to resume amphetamine, with its beneficial effects being much stronger again. There is ALOT of evidence, that Memantine and other NMDA antagonists/glutamate antagonists reduce some of the neurotoxicity of Amphetamine. Some of the neurotoxicity will remain, regardless of NMDA antagonism.....however, glutamate itself, is responsible for a significant portion of amphetamine-induced neurotoxicity......honestly, Memantine appears to be, almost perfect, without any obvious shortcomings. It will only be a matter of time, before a negative effect of such, is discovered, but nevertheless, Its positive effects, appear to greatly outweigh its cost. Yay for memantine[/QUOTE] [QUOTE]I'm not concerned with development of tolerance as I've been able to maintain a constant effect from amphetamines for months now without raising dose. In all fairness, I do take 60mg Delsym (dextromethorphan polystirex) twice daily, which is quite likely preventing tolerance. My pdoc endorses the use of DXM to all his stimulant-treated patients now, ever since I brought it to his attention months ago. He's seeing many patients finally stabilized on doses of amphetamines whereas they used to escalate monthly or even weekly. It doesn't seem to be working as well for his patients taking methylphenidate.[/QUOTE] Fascinating :D
[QUOTE=Mindtwistah;40011930]A sensible conclusion though I am unsure if that is the full extent of opioid tolerance and the mechanisms of NMDA anti-opioid action as much about is yet unknown, and many anecdotal reports raise interesting points that go against your hypothesis. A Japanese study regarding the role of neuronal plasticity caused by NMDA and other non-opioid systems in opiate dependence: And related: Another study where (+)-HA966 was found to potentiate morphine as well as reverse tolerance: Reports from user LightCloud at Flashback stating that 3-HO-PCP does in fact have many opioid-like qualities with a great deal of euphoria: And numerous general reports of NMDA-antagonists + opiate combination where it is always claimed the opiate effects did not grow weaker and were in some cases enhanced, something which doesn't make sense if a reduction of electric charge is the sole (or even main) reason for the tolerance-restrictive effect of NMDA-antagonism: Also of note for us amph users is that NMDA-antagonists seem to do even bigger miracles with stimulants by apparently reducing many side-effects like rapid pulse and vasoconstriction, potentiating the positive effects as well as effectively blocking tolerance-increase. Fascinating :D[/QUOTE] What other substances and foods can you ingest that contain NMDA antagonists? Also how dangerous is mixing opiates with a medical dose of DXM? just curious after lil wayne's whole fiasco.
[QUOTE=zach1193;40012029]What other substances and foods can you ingest that contain NMDA antagonists? Also how dangerous is mixing opiates with a medical dose of DXM? just curious after lil wayne's whole fiasco.[/QUOTE] I don't think there are many (if any) foods containing NMDA-antagonists, at least not in any significant amount. Or maybe there are but I have never heard of it :v: DXM seems to be the most widely used NMDA-antagonist for blocking opiate tolerance and is safe to use in therapeutic doses, but there have been reports of unpleasantness if too large a dose of DXM is taken.
how much dexedrine is equivalent to 10mg ritalin? i'd take a wild guess at 5mg dex being equal to 10mg?
[QUOTE=polarbear.;40012821]how much dexedrine is equivalent to 10mg ritalin? i'd take a wild guess at 5mg dex being equal to 10mg?[/QUOTE] Dextro-amphetamine and Methylphenidate don't have equivalent doses. However Since Dexedrine is all d-amp compared to Adderall which is dl-amp, 10mg of Dexedrine is equal to 7.5mg of Adderall.
[QUOTE=SuperNatural;40010847]Why put white/yellow powder on white paper? Use a dark background for light colours. Well from what I can see that is not .5g of MDA, looks like maybe .2g so a single dose orally. You said you paid $20 and it was a total of $80 for an eighth? If 4 people pitched $20 each for 3.5g of MDA you should be getting .8g. [editline]23rd March 2013[/editline] Oh and salt cannot be compared to MDA. Where in Canada do you live? I live in BC, street Dexedrine(Dextro-amphetamine) caps go for $20 for 45mg(15mg caps) in Vancouver, that is a high price so I try to find people with Dexedrine scripts and pay maybe $10 for 40mg. Imo MDA is very stimulating I used to binge on it and use it instead of some d-amp. Nobody here can really suggest "decent/cheap amphetamines" because it depends on where you live and what is available to you from your dealers.[/QUOTE] We paid $80 total, and it's $60 a gram, so we got around 1.5g. They both paid $30 and I paid $20. I meant I got an eighth of chronic as well. :v: I had no black paper or surface to put it on, other than my leather wallet but fuck that. Since we had to divide it into 3, I didn't get the original bag for it.
How does redosing etizolam go? Currently on 1 mg , though I took .5 then another .5 within the following two hours. Would adding another .5 do much more for me?
[QUOTE=Toz;40014448]We paid $80 total, and it's $60 a gram, so we got around 1.5g. They both paid $30 and I paid $20. I meant I got an eighth of chronic as well. :v: I had no black paper or surface to put it on, other than my leather wallet but fuck that. Since we had to divide it into 3, I didn't get the original bag for it.[/QUOTE] hmmm, well that still doesn't look close to .4, hope it was/is really good at least!
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[QUOTE=lemongrapes;40000653]Never tried one, but from what I've heard it's well worth it if you can afford the initial cost. Saves a lot of money in the long run if you're a heavy smoker, healthier too. And discrete. So basically, yeah it probably is.[/QUOTE] I've been thinking about it lately. A friend of mine bought one and I had the chance to test it out. It's a neat little machine, but it's a lot different from my usual water pipe. Though you get very high off of very little. I may consider investing in one.
[QUOTE=SuperNatural;39991272]Oh I agree in his case but August said "Don't smoke weed before you trip, but you can smoke hella during and after", it seemed he was referring to anyone in general because why would he suggest not smoking before but while tripping for Faz? [editline]21st March 2013[/editline] Paranoia would be worse for Faz(In theory) if you smoked while tripping rather than before.[/QUOTE] I always smoke on the come up to ease my paranoia and comeup jitters.
How large should I dose for my first time taking Klonopin? And how long will the effects last?
[QUOTE=Dougz;40025799]How large should I dose for my first time taking Klonopin? And how long will the effects last?[/QUOTE] I suggest 2mg for your first time, the effects generally last about 4 hours though it can be up to 6 hours.
derp wrong klonopin lasts 12 hours
what kind of peanut butter do you guys typically like? creamy or crunchy?
[QUOTE=NeoSeeker;40026320]derp wrong klonopin lasts 12 hours[/QUOTE] You stay high on Klonopin for 12 hours? I'm not saying the effects only last 4-6 hours I'm saying the main effects and "high" will last about that long. I have taken Clonazepam hundreds maybe thousands of times and have never been high for 12 hours from it.
it pretty much lasts till i fall asleep. it's not like a benzo high is really noticeable either. you're still high after that 6 hour point, you just don't know it.
[QUOTE=NeoSeeker;40026842]it pretty much lasts till i fall asleep. it's not like a benzo high is really noticeable either. you're still high after that 6 hour point, you just don't know it.[/QUOTE] If you take enough Clonazepam a Benzo high is extremely noticeable. I know a lot of Benzo lightweights who still feel the effects after 6 hours and sometimes the next day. A normal user will not normally have this.
[QUOTE=brianosaur;40026580]what kind of peanut butter do you guys typically like? creamy or crunchy?[/QUOTE] Creamy, master race.
[QUOTE=Mac2468;40027089]Creamy, master race.[/QUOTE] this guy gets it
[QUOTE=brianosaur;40026580]what kind of peanut butter do you guys typically like? creamy or crunchy?[/QUOTE] Drugs Discussion in a nutshell
[QUOTE=Cpn Crunch21;40027106]this guy gets it[/QUOTE] Cpn Cream21
Should I take Advil or Tylenol?
mix them both in the same syringe and inject it into your dick
[QUOTE=Sikeman214;40028284]Should I take Advil or Tylenol?[/QUOTE] you know you can take both at the same time and they work like way better. you can mix tylenol with something else too, but you can't mix the things you can mix with tylenol.
Can you guys give me some info about peyote? What is the trip like and what should I expect?
I've never dealt with amphetamine sulfate powder and am thinking of getting some off SR. Has anyone done both powder and pharmaceutical amphetamines? I know the paste will be cut but should I still the dose the same as I would with Dexedrine? The vendor says it's >96% pure amphetamine sulfate @ ฿0.41 for 1g. Though I'm sure the purity is far from that number. Also is this what people refer to as amphetamine paste?
[QUOTE=SuperNatural;40034253]I've never dealt with amphetamine sulfate powder and am thinking of getting some off SR. Has anyone done both powder and pharmaceutical amphetamines? I know the paste will be cut but should I still the dose the same as I would with Dexedrine? The vendor says it's >96% pure amphetamine sulfate @ ฿0.41 for 1g. Though I'm sure the purity is far from that number. Also is this what people refer to as amphetamine paste?[/QUOTE] Pharmaceutical amph will always be much purer than regular amph, think about two to four times the dosage required if it's high quality paste or powder (usually between 25-65% from what I've heard, the upper range is only in the absolute best cases) and much more if it's lower quality (street amph usually has a purity of 5-15% according to most sources). It's hard to get accurate figures though because there is very little factual information regarding the purity of amph, the absolute majority of info going around is anecdotal and often contradicting, no one really knows anything for sure it seems lol And the vendor is bullshitting, there is no way his amph is that pure. You should always check the ratings and what people have commented about the product, but I have never heard of amph being sold with a purity of over 75-80%, and this is extremely rare and requires very good connections with Russian mob bosses or a lab in Poland or something :v: Amph paste is when the amphetamine is wet and looks sort of like a paste, supposedly as it hasn't been fully dried from the manufacturing process (again there's no general consensus on why but it's the most common explanation going around). It's generally very strong in smell and has a rather high potency, usually at least 25%. There's seemingly also a lot of "fake-paste" circulating where it's simply been cut with water to increase the weight and make it look like paste. If what the vendor sells is paste the picture should look like it and he should mention it somewhere on his page. Also again read the comments for better info as vendors often lie and exaggerate (who would've though eh :p) Powder can be just as pure as paste but the majority of shit amph is powder as well. Could you link the vendor page? It won't really do harm, SR is a public website well-known to law enforcement and this is a private subforum :) I'll look around and see what seems to be good, have never browsed the international amph listings lol
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