[QUOTE=zach1193;35552834]No, I know you didn't say that, I read it in a magazine article about it. And I'm pretty sure CBD and THC are only found in Hemp and Pot. And it's certainly possible considering weed has been around for thousands of years.
Also I'm not a very good advocate for this topic in particular, but it made sense when I read it, maybe I'll look it up again and see what it said.
Alright, here taken directly out of the article of high times:
"I always like to finish articles like this by pointing out that human cannabinoid receptors such as [B]CB1 and CB2 are extremely interesting in that they're what convert the plants chemical compounds into a psychoactive/medicinal experience[/B]. That there is mutual symbiosis between cannabis plants and human beings that is "binding site specific" is miraculous- and monumental: It implies that throughout human and cannabis evolution, there has been a historic connection between our species."
Then it goes on to talk a little bit about how seeds and hemp cloth etc. has been found in archaeological digs and that weed isn't a new thing, which I'm sure many of you already knew.[/QUOTE]
that guy has no idea what he is talking about regarding pharmacology, hell even in the evolution sense. First of all, evolution takes millions of years to develop the smallest of changes, [B]especially[/B] when the organism has a long lifespan i.e humans. Also the fact that the plant doesnt grow everywhere around the world and that its unlikely [I]every[/I] caveman who encountered it smoked it let alone enough to somehow miraculously grow a new brain structure for future generations... you get it, its not possible. Regarding the fact that our receptors are "binding site specific" doesnt signify anything. When you compare THC and CBD to endocannabinoids they are very similar in pharmacology, which means THC and CBD are capable of binding to the same sites as cannabinoids. The most you can take out of this is that the chemical THC and CBD is easy to construct, along with endocannabinoids since you have two different life forms (actually ALL mammals have an endocannabinoid system, which is why you can get dogs, cats, etc high) that have succeeded in creating similar molecules. "If its so easy, why dont more plants produce it?" Because there was probably some event or genetic change that caused it to create it as a defensive measure (thats what some scientists theorize). Also, the bolded part there is one of the most retarded statements ive read. No shit if you overstimulate receptors in the brain that are responsible for mood, pain sensation, memory, and appetite that you are going to have a 'psychoactive experience'. The reason its good for you is that the chemical is close enough in chemical structure to not cause other problems. Its very close to natural human chemical compounds so even in excess (like smoking until you green out or some shit) you dont get serious problems, ie you dont really od. But when it comes to synthetic cannabis, its incredibly concentrated and can include either bad chems or be overly concentrated, maybe even for some people not compatible.
Ok, im not trying to bash you or anything, but I want to teach you these things because even though i doubt you will run into someone who goes this in-depth about it, i want you to be able to spread the correct knowledge. No offense but if any other scientist that knows the smallest bit about biology and neurology will look at that articles statement and laugh at the 'ignorance' (its not really ignorance, but misguidedness). You cant jump to conclusions as bold as, "humans and cannabis has a historic connection between species" without doing a bit of research/learning in neurology. Like, its not just humans, which is funny because since dogs/cats can also get high you would have to make the case by that logic that their ancestors were sitting around smoking cannabis. sigh* Look, if you create a chemical to stimulate a part of the brain, you cant say that the brain structure that reacted to the drug evolved to receive that particular drug exclusively. This is sort of a poor analogy but it would be like taking a light bulb, making an easy bake oven to use the light bulb to cook, and saying that the light bulb was engineered to produce tiny pastries.
[QUOTE=Cpn Crunch21;35555636]that guy has no idea what he is talking about regarding pharmacology, hell even in the evolution sense. First of all, evolution takes millions of years to develop the smallest of changes, [B]especially[/B] when the organism has a long lifespan i.e humans. Also the fact that the plant doesnt grow everywhere around the world and that its unlikely [I]every[/I] caveman who encountered it smoked it let alone enough to somehow miraculously grow a new brain structure for future generations... you get it, its not possible. Regarding the fact that our receptors are "binding site specific" doesnt signify anything. When you compare THC and CBD to endocannabinoids they are very similar in pharmacology, which means THC and CBD are capable of binding to the same sites as cannabinoids. The most you can take out of this is that the chemical THC and CBD is easy to construct, along with endocannabinoids since you have two different life forms (actually ALL mammals have an endocannabinoid system, which is why you can get dogs, cats, etc high) that have succeeded in creating similar molecules. "If its so easy, why dont more plants produce it?" Because there was probably some event or genetic change that caused it to create it as a defensive measure (thats what some scientists theorize). Also, the bolded part there is one of the most retarded statements ive read. No shit if you overstimulate receptors in the brain that are responsible for mood, pain sensation, memory, and appetite that you are going to have a 'psychoactive experience'. The reason its good for you is that the chemical is close enough in chemical structure to not cause other problems. Its very close to natural human chemical compounds so even in excess (like smoking until you green out or some shit) you dont get serious problems, ie you dont really od. But when it comes to synthetic cannabis, its incredibly concentrated and can include either bad chems or be overly concentrated, maybe even for some people not compatible.
Ok, im not trying to bash you or anything, but I want to teach you these things because even though i doubt you will run into someone who goes this in-depth about it, i want you to be able to spread the correct knowledge. No offense but if any other scientist that knows the smallest bit about biology and neurology will look at that articles statement and laugh at the 'ignorance' (its not really ignorance, but misguidedness). You cant jump to conclusions as bold as, "humans and cannabis has a historic connection between species" without doing a bit of research/learning in neurology. Like, its not just humans, which is funny because since dogs/cats can also get high you would have to make the case by that logic that their ancestors were sitting around smoking cannabis. sigh* Look, if you create a chemical to stimulate a part of the brain, you cant say that the brain structure that reacted to the drug evolved to receive that particular drug exclusively. This is sort of a poor analogy but it would be like taking a light bulb, making an easy bake oven to use the light bulb to cook, and saying that the light bulb was engineered to produce tiny pastries.[/QUOTE]
Oh by no means were we arguing man, and I always want to know correct knowledge. You see why I thought what I thought though, it was in a pretty popular weed magazine, I assumed it was correct information. Thanks though, now I won't go about telling all my buddies that haha
I have a question though, what else produces endocannabinoids?
[QUOTE=zach1193;35556285]Oh by no means were we arguing man, and I always want to know correct knowledge. You see why I thought what I thought though, it was in a pretty popular weed magazine, I assumed it was correct information. Thanks though, now I won't go about telling all my buddies that haha
I have a question though, what else produces endocannabinoids?[/QUOTE]
well the term endocannabinoids is specifically for those made within the body. Cannabinoids is the family or group that endocannabinoids fall under. There are three types in the grouping and its by where/what its made from. Synthetic is man-made in a lab, phytocannabinoids are made by plants, and endo by animals in which humans fall under (naturally). There is a small list of plants besides Cannabis that create cannabinoids, wiki shows them [url=http://en.wikipedia.org/wiki/Cannabinoids#Phytocannabinoids]here[/url]. I havent read up on them and what chems they produce, so thats as far as ive gone on that. Wikipedia is a good source, but without an understanding of biology, little bit of chemistry, neuropsychology, and phisiological psychology, its hard to compile the information into something meaningful. You can memorize what CB receptors do by definition (activating lets say, GABA and AMNA receptors or something) but without knowing what that means for the brain and how it functions, you get stuck at the definition thinking "well then where does this leave me? What does this all mean?"
Even if you were to read my megathread, there are so many things i left out of it when it comes to how the brain works that its just not enough to go to a wiki page and really be able to apply it. (i have still yet to finish that damned thread after deciding to add the cannabis section to it, fuck im lazy) I did design it so that it would be easier to understand the pharmacology of some drugs, and be able to kind of understand wiki's pharmacology descriptions of drugs. But there is so much more, and if you dont know what part of the brain is effected, or what it is responsible for then, shit just go to college hahah.
-snip- nvm haha
[QUOTE=Cpn Crunch21;35556891]well the term endocannabinoids is specifically for those made within the body. Cannabinoids is the family or group that endocannabinoids fall under. There are three types in the grouping and its by where/what its made from. Synthetic is man-made in a lab, phytocannabinoids are made by plants, and endo by animals in which humans fall under (naturally). There is a small list of plants besides Cannabis that create cannabinoids, wiki shows them [url=http://en.wikipedia.org/wiki/Cannabinoids#Phytocannabinoids]here[/url]. I havent read up on them and what chems they produce, so thats as far as ive gone on that. Wikipedia is a good source, but without an understanding of biology, little bit of chemistry, neuropsychology, and phisiological psychology, its hard to compile the information into something meaningful. You can memorize what CB receptors do by definition (activating lets say, GABA and AMNA receptors or something) but without knowing what that means for the brain and how it functions, you get stuck at the definition thinking "well then where does this leave me? What does this all mean?"
Even if you were to read my megathread, there are so many things i left out of it when it comes to how the brain works that its just not enough to go to a wiki page and really be able to apply it. (i have still yet to finish that damned thread after deciding to add the cannabis section to it, fuck im lazy) I did design it so that it would be easier to understand the pharmacology of some drugs, and be able to kind of understand wiki's pharmacology descriptions of drugs. But there is so much more, and if you dont know what part of the brain is effected, or what it is responsible for then, shit just go to college hahah.[/QUOTE]
Hahahaha I am going to (finally, I'm 19) college in the fall. But yea, the brain is a very complex organ, I mean, it is "you". And I have yet to see the megathread, is it out? I haven't seen it haha
when I first started smoking, I thought weed tasted kinda like pepperoni
[QUOTE=SHOE3045;35567145]when I first started smoking, I thought weed tasted kinda like pepperoni[/QUOTE]
Musta been some bad pepperoni haha
or some delicious weed
Smoking it your first time isn't going to be the best, but after that, everything changes, it starts to taste and smell delicious.
For the first couple of times I started smoking I thought weed tasted like crap. Eventually the taste turned into a somewhat peanut buttery taste and now it tastes good every time I smoke. Maybe because before I would pick up from dealers and moved up to medical marijuana and dealers who sell medical marijuana.
[QUOTE=zach1193;35567005]Hahahaha I am going to (finally, I'm 19) college in the fall. But yea, the brain is a very complex organ, I mean, it is "you". [B]And I have yet to see the megathread, is it out?[/B] I haven't seen it haha[/QUOTE]
once i get over my lazyness i will finish it and post it. So it might be a long time, it might be a short time, lol.
[QUOTE=Cpn Crunch21;35571641]once i get over my lazyness i will finish it and post it. So it might be a long time, it might be a short time, lol.[/QUOTE]
lol, well whatever the time, I'll be waiting haha
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