Mouse gene found in humans raises hippocampus growth when DEactivated - Polidicks

[QUOTE=bravehat;25375231]Issue is that's illegal, since you know, it's not their own life they're fucking around with. Doing this has to be done in mice and be observed constantly til they die, and in death you need to find out what killed them and how the deactivation of this gene may or may not have contributed to this, then you need to publish your findings and results, and then repeat it to prove your point. Then maybe some country with less ethical restraints will offer this to some people to set up a human trial.[/QUOTE] Yeah, let's set up a secret base in Venezuela, carry out our research there. Sometimes, one must sacrifice their morals and ethics in exchange for knowledge and power.

This might be testable on already grown people. Brain keeps developing. Viruses can alter your DNA. There are already ongoing experiments on modifying viruses and what they actually do. As it seems, the gene changes more of propriety of the brain, than it's construction, so it might work even on already formed brain. I would volunteer.

Are you not getting this? This fundamentally alters the operation of your brain there could be massive unforeseen and unpredictable issues with this, and using a modified retrovirus is still shaky ground thanks to how fast and easily viruses adapt and evolve to fir their conditions.

[QUOTE=bravehat;25364674]Nah genes don't turn off ever, they either fully active or being repressed by another, if that one then becomes repressed the first is made functional and performs its task. That's why turning this off is a problem cause it has a knock on effect that could cause cells in the body to produce toxins for example.[/QUOTE] Yes they do, there are many mechanisms through which genes can be completely non-expressed. Methylation, for example. There are also genes whose sole purpose is the regulation of other genes. What you're saying isn't true at all. [QUOTE=bravehat;25364982]Pretty sure genes change pretty fast in evolution cause if they didn't we wouldn't change in any way.[/QUOTE] The rate of mutation is lower than you'd think. (175 Nucleotides p/diploid genome, p/generation[url=http://www.genetics.org/cgi/content/full/156/1/297][1][/url]) Most of these are also in the non-coding regions of the genome, and don't actually change the phenotype. [QUOTE=bravehat;25375231]Issue is that's illegal, since you know, it's not their own life they're fucking around with. [/QUOTE] It's actually more infeasible than illegal; I don't think there's any law against it, but we can barely make knockout rats, never mind knockout humans. Gene insertion? That we can do just fine, by a number of methods. [QUOTE=bravehat;25375664]Are you not getting this? This fundamentally alters the operation of your brain there could be massive unforeseen and unpredictable issues with this, and using a modified retrovirus is still shaky ground thanks to how fast and easily viruses adapt and evolve to fir their conditions.[/QUOTE] -viridae can't remove DNA, anyway, only insert. Also, the risk with using a retrovirus or lentivirus based vector for inserting DNA is less that the virus will go on to replicate and mutate (they won't, they're replication-defective), the issue is that they pseudo-randomly insert into the genome near (+/- 1-2Mbp) a certain loci. This is what causes cancer with these, not any weird replication issues. I do agree that doing this to someone would be a bad idea, as it's fucking with a gene that regulates for brain functioning, and until we know the gene network it's potentially involved in, there could be unseen risks.

This came to mind: [img]http://scienceblogs.com/worldsfair/upload/2006/08/118.jpg[/img]

is it morally right to fuck up with mice and their genes to further research this.. DNA-subject? [editline]13th October 2010[/editline] [QUOTE=Big Dumb American;25375187]I will donate my baby to science. Is there a "really excellent physique" and "super charming to ladies" gene as well? I don't ever want my boy to have trouble getting laid. While we're at it, let's activate the "super ambitious and always successful" gene, too.[/QUOTE] Yeah and some people have the gene that gives them tendency to drug-abuse or whatever, even if they didn't want to. This is a double-edged sword, but to me it seems like there are 2 options (eventually) Option A would be NOT to hassle around with genes at all. Option B, make all humans technically perfect. Are moles okay? No? Okay, your baby won't have em. Retards would be obviously a no-go, and we wouldn't have them slowing us down in the near future, right? As rude as it may sound, it sounds like a fantasy story.

[QUOTE=bravehat;25375664]Are you not getting this? This fundamentally alters the operation of your brain there could be massive unforeseen and unpredictable issues with this, and using a modified retrovirus is still shaky ground thanks to how fast and easily viruses adapt and evolve to fir their conditions.[/QUOTE] Of course, when it gets properly developed and tested on animals. But still, I would rather put myself into danger willingly, than to test it on unborn who can't choose.

[QUOTE=bravehat;25363718]It could be that as we evolved that gene played a part in stemming brain growth to reduce cancers or to sacrifice greater intelligence and memory for efficiency, the brain already uses up something 25% of the bodies total energy intake, I can't imagine how crazy it would be if the brain required even more.[/QUOTE] People would have to eat more frequently?

[QUOTE=Awesomecaek;25378056]Of course, when it gets properly developed and tested on animals. But still, I would rather put myself into danger willingly, than to test it on unborn who can't choose.[/QUOTE] I wholeheartedly agree. I'd volunteer for this, seeing as a baby cannot choose, and I can. I'd do it for science, hell, I'd do it for humanity. Anything that may help us as a whole in the future. [editline]13th October 2010[/editline] [QUOTE=DeanWinchester;25378154]People would have to eat more frequently?[/QUOTE] Yes, but we would not get fat, since the brain would require more nutrients, and putting out more stomach acid, etc. to help it along.

[QUOTE=bravehat;25364674]That's why turning this off is a problem cause it has a knock on effect that could cause cells in the body to produce toxins for example.[/QUOTE] So we could start spitting venom? I don't see any downside to this.

Neuroscience is really cool stuff.

[QUOTE=Bat-shit;25377738]is it morally right to fuck up with mice and their genes to further research this.. DNA-subject? [editline]13th October 2010[/editline] Yeah and some people have the gene that gives them tendency to drug-abuse or whatever, even if they didn't want to. This is a double-edged sword, but to me it seems like there are 2 options (eventually) Option A would be NOT to hassle around with genes at all. Option B, make all humans technically perfect. Are moles okay? No? Okay, your baby won't have em. Retards would be obviously a no-go, and we wouldn't have them slowing us down in the near future, right? As rude as it may sound, it sounds like a fantasy story.[/QUOTE] Just, shut up and stop making yourself look like an asshat. Morals are entirely subjective, some people think it's perfectly moral to kill people for no reason, peel off their flesh and fry it like bacon, some people see it as horribly immoral to have a kid outside of marriage. Dick around with mice all you want, they're lesser creatures and we've grew human fucking ears on them before this is just us fucking around with them internally. [editline]13th October 2010[/editline] [QUOTE=Lambeth;25378778]So we could start spitting venom? I don't see any downside to this.[/QUOTE] ...you're a credit to your people son and you'll go very far in this world.

[QUOTE=bravehat;25381515]Just, shut up and stop making yourself look like an asshat. Morals are entirely subjective, some people think it's perfectly moral to kill people for no reason, peel off their flesh and fry it like bacon, some people see it as horribly immoral to have a kid outside of marriage. Dick around with mice all you want, they're lesser creatures and we've grew human fucking ears on them before this is just us fucking around with them internally.[/QUOTE] Hold it man, I'm all down improving humankind through research that involves killing/whatever animals, all the way down. Whether it's morally right or wrong, it's an endless debate, but obviously some people care about these morals

Yeah, and they are holding back the species and should be culled off. We are more important than some fucking mice.

[QUOTE=bravehat;25381515]...you're a credit to your people son and you'll go very far in this world.[/QUOTE] I was joking.

[QUOTE=Lambeth;25382151]I was joking.[/QUOTE] Rate me dumb, sarcasm detection is cripplingly difficult with a migraine :sigh:

[QUOTE=bravehat;25382260]Rate me dumb, sarcasm detection is cripplingly difficult with a migraine :sigh:[/QUOTE] Get off your computer, take some painkillers and lie down in your bed and switch the light off. I can't understand how anyone can do anything with a migraine apart from that. D:

Let's say this does give us great memory, although maybe it's the gene that allows us to forget certain things. Let's say you see a goatse you remember it perfectly for the rest of your life everytime you close your eyes. It would be horrible, we see crazy shit all the time but our minds slowly forget it. We don't want to remember everything we see and hear, most of the time we do. Although who knows, I just say we leave our brains alone. We have evolved before so I just think we should just let our evolution continue on it's process and not alter it. On the other hand I think voluntary test on humans should be legal and allowed. We could discover so many things this way.

Sometime later... "Dolores, MY baby got his hippocampus inhibitor deleted, he's top of his kindergarten astrophysics class."

Immediately thought of stargate and ascended beings.