Scientists find how obesity gene works, a clue to treatment - Polidicks

[QUOTE=nagachief;48517346]I'm sort of been rather confused as of lately. I've attempted to eat less/more healthy, but all it resulted in is damn near narcolepsy from exhaustion and extreme irritability. And extreme indigestion to the point I feel like throwing up. In my younger days I have been so hungry a couple of times I threw up pure stomach acid. I've been unable to lose weight at all. When I exercise, I get tired out faster than everyone else I know for as long as I can remember, and was told I was faking it constantly. Also once I start sweating, game over. That's pretty much pure concentrated energy leaving my body to the point where I literally cannot recover from exhaustion no matter how much fluids I take in. I've also been told by doctors that I have Alpha Thalmassemia and that it means my body doesn't absorb nutrients properly and puts me with chronic anmeia, could this gene and my genetic disorder be making it nigh impossible to lose weight?[/QUOTE] If physicians have told you you have some sort of disorder, then yes, that may be a significant factor. Sometimes there are just problems you can't control -- you could try working with a dietitian/nutritionist about what kinds of foods/how much quantity you can eat in a sitting/medications you could take to help combat this problem.

Claiming that you're obese because of genetics when it's actually not is just as stupid as saying that all fat people should just get off their arses and do something because not exercising and eating badly are the [I]only[/I] reasons people gain weight. But it's funny how people on either side of the issue tend to just ignore a lack of research as long as it supports [I]their[/I] viewpoint, right?

[QUOTE=aznz888;48517359]If physicians have told you you have some sort of disorder, then yes, that may be a significant factor. Sometimes there are just problems you can't control -- you could try working with a dietitian/nutritionist about what kinds of foods/how much quantity you can eat in a sitting/medications you could take to help combat this problem.[/QUOTE] I have seriously thought about it, considering that I want to avoid ending up like my father. He's got high blood pressure and so many aches and pains from his weight that it's something I desperately want to avoid.

They found a cure for big-boned-itis?

[QUOTE=Headhumpy;48514865]No one said that it automatically made you obese. Just like how no one says oncogenes automatically make you get cancer. They do, however, increase your risk of getting it over your lifetime.[/QUOTE] He was responding to a post saying it had a minuscule effect, and while 7 pounds may not be minuscule, it isn't that much of a difference either. Especially considering 44% of Europeans have it.

Facepunch expert on everything Dr. Toro, P.h.D in Everything here. I can confirm that there are no genes/disorders that contribute to weight gain, this article is bullshit and anyone who disagrees with me obviously doesn't know ANYTHING about anatomy and genetics.

50% of posters here are retards who cannot even read article and think. Did it occurred to you that some people get FAT at lighting speed while other WISH to gain weight and CANT?

[QUOTE=Fourier;48519848]50% of posters here are retards who cannot even read article and think. Did it occurred to you that some people get FAT at lighting speed while other WISH to gain weight and CANT?[/QUOTE] did it occur to you it is physically impossible to gain body weight without the necessary energy to support it? regardless of the existence of a gene that possibly contributes to obesity (and some folks, like yourself, like to conveniently forget that genes aren't a genetic stone tablet, they are activated or [I]expressed[/I] by factors in their environment. You have muscle building genes that are only heavily expressed in response to repeated acute stress on the skeletal muscle - how many folks do you see that are walking around with massive muscles that don't exercise?), the causative factor in obesity as proven by literally decades of repeated studies, meta-analysis etc is caloric intake. People like to cite obscure studies that support their views with shitty methodology like self reported intake, but its curious how they never want to cite the gold standard - metabolic ward studies were patients are tracked and monitored on their food intake. Thats because when you do that it becomes abundantly clear the other influencing factors are far and away insignificant compared to number one with a bullet: caloric surplus. you cannot just get obese accidentally. [B]It is physically impossible to gain weight without consuming the necessary energy to support the creation of that new tissue[/B]. Or do you actually believe some people just get fat via osmosis? Genetic determinism is a comfortable fallacy for many people. Learned helplessness is what psychologists call it.

[QUOTE=dilzinyomouth;48520074]did it occur to you it is physically impossible to gain body weight without the necessary energy to support it? ...[/QUOTE] But did you read the article? It clearly states that fiddling with the gene made mouse leaner while having same caloric intake as unmodded mouse.

[QUOTE=itisjuly;48520112]But did you read the article? It clearly states that fiddling with the gene made mouse leaner while having same caloric intake as unmodded mouse.[/QUOTE] The average weight difference between humans with this genetic problem is 7 pounds. Which is almost negligible to most adult sized humans

[QUOTE=itisjuly;48520112]But did you read the article? It clearly states that fiddling with the gene made mouse leaner while having same caloric intake as unmodded mouse.[/QUOTE] Its an article. Its not the study. It doesn't say anything about the caloric intake. All it says is both were fed a high-fat diet. So without knowing that, there is no way to draw accurate conclusions. Maybe they did control the diet, maybe they didn't. Maybe inhibiting the gene caused the knockout mice to eat less overall. Maybe not. Don't make shit up.

[QUOTE=Perfumly;48520118]The average weight difference between humans with this genetic problem is 7 pounds. Which is almost negligible to most adult sized humans[/QUOTE] It's a 'clue', not a solution. It might lead to something bigger, it might not.

The type of weight you gain is also important to remember guys, for example, telling someone you gained 1kg is pretty stupid, and outright wrong in most cases. What people should be concerned with is lean mass and body fat %, watching your diet and how it affects these two numbers will indicate if you're doing the right thing. Furthermore, most people don't even know how to weigh themselves correctly, like people will just weigh themselves, instead of weighing themselves when they're dehydrated, just taken a shit/piss first thing in the morning before eating. I can gain 2.5kg just in water weight in the period of 2 hrs while working out. Yes, genes will effect you as a person, however, it should not be used as an excuse for being obese. If you do have a disorder, you need to work out a way to overcome it, not accept it.

The obesity gene is very real. My dad had it, and even living a super healthy lifestyle, going to the gym, constantly eating protein rich foods, etc -- when he first started he lost 80 pounds. He still just couldn't keep the weight off and died of a heart attack before 45. They're not trying to make people with high metabolism feel less like special snowflakes or something, they're trying to eliminate a gene which poses a very real risk for people

[QUOTE=dilzinyomouth;48520074]did it occur to you it is physically impossible to gain body weight without the necessary energy to support it? regardless of the existence of a gene that possibly contributes to obesity (and some folks, like yourself, like to conveniently forget that genes aren't a genetic stone tablet, they are activated or [I]expressed[/I] by factors in their environment. You have muscle building genes that are only heavily expressed in response to repeated acute stress on the skeletal muscle - how many folks do you see that are walking around with massive muscles that don't exercise?), the causative factor in obesity as proven by literally decades of repeated studies, meta-analysis etc is caloric intake. People like to cite obscure studies that support their views with shitty methodology like self reported intake, but its curious how they never want to cite the gold standard - metabolic ward studies were patients are tracked and monitored on their food intake. Thats because when you do that it becomes abundantly clear the other influencing factors are far and away insignificant compared to number one with a bullet: caloric surplus. you cannot just get obese accidentally. [B]It is physically impossible to gain weight without consuming the necessary energy to support the creation of that new tissue[/B]. Or do you actually believe some people just get fat via osmosis? Genetic determinism is a comfortable fallacy for many people. Learned helplessness is what psychologists call it.[/QUOTE] I know genes can be turned on and off. No, I don't believe people get fat via thin air, what the fuck? It's logical you need to eat shit to make shit. It's just that some metabolisms burn/shit food easily where other metabolisms just store it as fat. Is this difference hard to understand? If it is not (turned on/off) genes, then what it is?

i'll just leave this here [t]http://i.imgur.com/njabmin.png[/t]

[QUOTE=Sand Castle;48522105]The obesity gene is very real. My dad had it, and even living a super healthy lifestyle, going to the gym, constantly eating protein rich foods, etc -- when he first started he lost 80 pounds. He still just couldn't keep the weight off and died of a heart attack before 45. They're not trying to make people with high metabolism feel less like special snowflakes or something, they're trying to eliminate a gene which poses a very real risk for people[/QUOTE] The difference between someone with a "fast" metabolism and a "slow" metabolism is no more than 250 calories a day. If he had a hard time keeping the weight off, it's because he had a hard time maintaining a proper diet.

[QUOTE=Fourier;48523011] If it is not (turned on/off) genes, then what it is?[/QUOTE] Increased caloric consumption and increasingly sedentary lifestyles. This isn't rocket science, and its the only consistently correlating factor over the last 50 years, and in particular the last 20 years. [img]http://media.mercola.com/assets/images/obese.gif[/img] Caloric consumption is much harder to track because it relies on self-reporting which people are typically very bad at, but the trend still holds true even if the data varies slightly from source to source: [img]http://static1.businessinsider.com/image/523228ca69bedd766096670d/chart-of-the-day-the-moment-when-american-calorie-consumption-went-ballistic.jpg[/img] Coupled with this is the patently obvious observation anyone can make that our outdoor activity levels have dropped precipitously. Kids AND adults spend far more time inside, seated in front of of tvs, computers and phones than any prior generation. As jobs have become more automated, physical labor has dropped as well. Drug companies love genetic studies because they can pull information out of context and capitalize off scare mongering. People aren't fat because of a faulty gene, they are fat because they consume a shit ton of food and move very little.

I don't know what kinda fucked up genes I have, but I just can't seem to gain fat no matter what really. I don't even do bodybuilding or exercise a lot, just some general activity, and my diet does include its unhealthy/supposedly fattening pieces like downing the occasional potato ship bag, or cheese pizza Fridays..

[QUOTE=Bat-shit;48524733]I don't know what kinda fucked up genes I have, but I just can't seem to gain fat no matter what really. I don't even do bodybuilding or exercise a lot, just some general activity, and my diet does include its unhealthy/supposedly fattening pieces like downing the occasional potato ship bag, or cheese pizza Fridays..[/QUOTE]But does your caloric intake exceed your expenditure? Count your daily calories.

I thought the leading cause of obesity was food.

[QUOTE=itisjuly;48524786]But does your caloric intake exceed your expenditure? Count your daily calories.[/QUOTE] Good question. Perhaps I should. [editline]24th August 2015[/editline] Hell, if my caloric intake doesn't exceed my expenditure, then I gotta say getting fat is some hard work. Unless you're genetically very disposed to it?

[QUOTE=Bat-shit;48525395]Good question. Perhaps I should. [editline]24th August 2015[/editline] Hell, if my caloric intake doesn't exceed my expenditure, then I gotta say getting fat is some hard work. Unless you're genetically very disposed to it?[/QUOTE] You'd be amazed at how much fat people actually eat.

[QUOTE=Bat-shit;48525395]Good question. Perhaps I should. [editline]24th August 2015[/editline] Hell, if my caloric intake doesn't exceed my expenditure, then I gotta say getting fat is some hard work. Unless you're genetically very disposed to it?[/QUOTE] people chronically underestimate their caloric intake and greatly overestimate how much activity they do during the day. See NotMeh's post above. This is why I say the only reliable "studies" of obesity tend to come out of metabolic wards - because in these places they can actually control all the variables and get data that isn't self reported.

[QUOTE=The Aussie;48500815]I'm just saying that even with the distinction between brown and white fat, different metabolic rates and so on, weight loss or gain is simply a matter of calories in calories out.[/QUOTE] but its not because there are genes that litterally determine whether your calories are being burned or not