Scientists can now block heroin, morphine addiction - Polidicks

[QUOTE=Morris Vander;37252431]I'm totally going to believe a junkie about how teh gubermint iz keping u down by banning addictive drugs that might kill you and ruin your life have fun getting AIDS and dying in a ditch/OD'ing and drowning in your own puke on the floor[/QUOTE] What the fuck are you talking about? junkie? I've never shot up in my life and the last opiates I did where weeks ago. Why don't you get off your high horse before you sound too much like an idiot.

[QUOTE=jakedog;37252540]What the fuck are you talking about? junkie? I've never shot up in my life and the last opiates I did where weeks ago. Why don't you get off your high horse before you sound too much like an idiot.[/QUOTE] Sorry, but I'm not inclined to believe someone who uses illegal drugs about anything, I'd rather just report them to the police [sp](I'm a bit sad I can't do so with you)[/sp]

Holy shit bro go back to 4chan or whatever hole you crawled out of. You really think I can't tell who's a troll?

[QUOTE=jakedog;37252606]Holy shit bro go back to 4chan or whatever hole you crawled out of. You really think I can't tell who's a troll?[/QUOTE] Sure seems like it, given how I'm not trolling. [sp] P.S, someone who disagrees with you isn't always a troll[/sp]

play nice hoodoo456

[QUOTE=jakedog;37252513]I made it keeping in mind DD has a pretty small niche of opiate users. I browse /opi/ a lot and I've never heard of an opiate Rc. I think it's better like that because it's all shit that people actually could get their hands on. Your complaint sounds to me like someone saying "elbows too point 0/10 would not fuck"[/QUOTE] Opiate rcs are easier to get your hands (and legal) sometimes and yes it is nit picking as you said but when you're touting your thread as a wealth of knowledge when it's incomplete, actually reading through it now it's not as bad as I originally thought but the fact you've mentioned nothing in the heroin section which is probably the one with the most information needed to prevent anything going wrong and fail to mention opium itself.

Oh god, can you people read/understand basic biology. "Both the central nervous system and the immune system play important roles in creating addiction, but our studies have shown we only need to block the immune response in the brain to prevent cravings for opioid drugs." The team has focused its research efforts on the immune receptor known as Toll-Like receptor 4 (TLR4). "Opioid drugs such as morphine and heroin bind to TLR4 in a similar way to the normal immune response to bacteria. The problem is that TLR4 then acts as an amplifier for addiction," Dr Hutchinson says. "The drug (+)-naloxone automatically shuts down the addiction. It shuts down the need to take opioids, it cuts out behaviours associated with addiction, and the neurochemistry in the brain changes - dopamine, which is the chemical important for providing that sense of 'reward' from the drug, is no longer produced." It basically interferes TLR4, which would normally enable you produce dopamine, and begin the addiction by making your body association "Heroin=dopamine". It means that you can still high as hell. (although you would not feel the "high" from dopamine, just the effects of the painkiller.)

This is pretty cool. One of the problems with normal naloxone is that people take extra opiates to overcome the antagonism and then when they use the same dose when they haven't taken Naloxone, they overdose.

I was pretty fucking confused for a second because I was mixing up naloxone with naproxen

[QUOTE=Destroyertf;37257888]Oh god, can you people read/understand basic biology. "Both the central nervous system and the immune system play important roles in creating addiction, but our studies have shown we only need to block the immune response in the brain to prevent cravings for opioid drugs." The team has focused its research efforts on the immune receptor known as Toll-Like receptor 4 (TLR4). "Opioid drugs such as morphine and heroin bind to TLR4 in a similar way to the normal immune response to bacteria. The problem is that TLR4 then acts as an amplifier for addiction," Dr Hutchinson says. "The drug (+)-naloxone automatically shuts down the addiction. It shuts down the need to take opioids, it cuts out behaviours associated with addiction, and the neurochemistry in the brain changes - dopamine, which is the chemical important for providing that sense of 'reward' from the drug, is no longer produced." It basically interferes TLR4, which would normally enable you produce dopamine, and begin the addiction by making your body association "Heroin=dopamine". It means that you can still high as hell. (although you would not feel the "high" from dopamine, just the effects of the painkiller.)[/QUOTE] Not necessarily. Androgenic Steroids exert the vast majority of their effect by binding/interacting to the Androgen Receptor, by removing this binding you are left with the processes that happen independent of the AR. Similarly here, by interfering with TLR4, it might kill addiction, but it's also probably going to have considerable impact on the effectiveness of the drug. Might still be enough to produce effective pain relief, since most opiates are considerably effective at low doses, but to get the desirable euphoria might be harder with naloxone on board. Maybe, maybe not. I seriously doubt you can have the best of both worlds, when something sounds too good to be true in medicine, it usually is.

If they mass produce these, the street value of Heroin and Morphine will drop to zero. Thus inadvertently destroy a portion of illegal drug trade. Imagine if they can create a drug that can actually block cocaine or marijuana addiction. This would seriously destroy the drug market

[QUOTE=BCell;37282685]If they mass produce these, the street value of Heroin and Morphine will drop to zero. Thus inadvertently destroy a portion of illegal drug trade. Imagine if they can create a drug that can actually block cocaine or marijuana addiction. This would seriously destroy the drug market[/QUOTE] Uh what First of all, you're assuming people wouldn't have to pay for naloxone. They would, and it's likely to be pretty fucking expensive. Secondly, you're assuming naloxone doesn't lower the dopaminergic effects of opiate abuse. Which means you're also assuming people are going to WANT to use this drug. Thirdly, you're assuming physiological dependance is the only problem faced. A lot of people abuse heroin because they want the high. Psychological addiction is very real.

[QUOTE=BCell;37282685]If they mass produce these, the street value of Heroin and Morphine will drop to zero. Thus inadvertently destroy a portion of illegal drug trade. Imagine if they can create a drug that can actually block cocaine or marijuana addiction. This would seriously destroy the drug market[/QUOTE] Are you actually being serious