MASSIVE SPOILERS - BEWARE
This story arc is all over the first title, in both the narrative and in the collectible intel (as well as in the sequel):
Harlan Wade = Alma and Alice’s father (Alma is far older than Alice actually)
Alma appears in two major different forms in the game. One as an eight year old (which represents when she was first put into cryostasis), the second more ‘gross’ version is the one that represents her at 24 (when she finally died after Harlan decided to disconnect her from life support)
Alma was a massively gifted psychic with ample abilities ranging from mind control to telekinesis. However, unlike most people with these abilities (they feed off their surroundings), Alma only fed off the negative energy from people. Thus, even at an early age she would induce nightmares in people and would cause scientists to have horrible illnesses. Henceforth, Harlan and the rest of the Project Origin/Icarus team decided to have her put in permanent suspended animation while they attempted to breed a “clone” or “successor”, if you will - FROM Alma (Harlan was under the impression that the ‘powers’ would be transferred in the process of carrying a child to term).
This process first produced Pointman (you’re character in FEAR) who was largely seen as a failure. The second child would be known as Paxton Fettel and took to all of the abilities his mother had quite quickly.
Long story short = Alma get’s pissed about the whole “taking my babies” thing, psychically connects minds with Fettel and forces him to kill some scientists at an early age. The project is closed, Alma is taken off life support and Fettel is locked up.
Some time later, Genevieve Aristede (president of the company that created the Origin/Icarus projects) decides that the project is still viable and sends in some scouting/recovery teams to the old offices. They are promptly destroyed (their presence awakens Alma’s latent psychic imprint - which is now extremely pissed off), as is a secondary team. Out of nowhere Paxton Fettel is “synch’ed” again via Alma’s psychic ability and gains control of the Replica Soldiers and goes off, murdering everyone and attempting to “release” Alma’s physical body from the cryostasis chamber.