Anything that uses nodes from Derma is screwed, and HTML interpretation is fubar. Main mods that use these nodes are expression2’s gui, and adv dupe 2. AD2 can take upwards of 20 minutes to load all folders, and will turn your framerate negative.
Multiple threads, garry already reported there are issues due to the hotfix and wait till monday.
Is this also why the Q menu freezes the game for a couple of seconds on opening it?
Something with the update must have made the GUI not optimized for speed.